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Piperidines

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Definition: A family of hexahydropyridines.     
See Also Pyridines
Examples Alphaprodine; Anabasine; Betalains; Biperiden; Cisapride; Clopamide; Cyproheptadine; Domperidone; Fentanyl; Flecainide; Fluspirilene; Imino Pyranoses; Indoramin; Isonipecotic Acids; Ketanserin; Ketotifen; Lobeline; Loperamide; Mepivacaine; Methylphenidate; Minoxidil; Nipecotic Acids; Paroxetine; Pempidine; Penfluridol; Perhexiline; Phencyclidine; Pipecolic Acids; Piperidones; Piperoxan; Ritanserin; Terfenadine; Trihexyphenidyl
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(4-chlorophenyl)-4-(3-(1-(2-(4-(2,4--dimethoxybenzoyl)phenoxy)acetyl)piperidin-4-yl)propyl)piperidine-1-carbothioamide  0   *Benzophenones *Piperidines. Chem Biol Drug Des. 2012 Mar;79(3):360-7.
N-(4-chlorophenyl)-4-(3-(1-(2-(4-(2,4-dimethoxybenzoyl)phenoxy)acetyl)piperidin-4-yl)propyl)piperidine-1-carboxamide  0   *Benzophenones *Piperidines. Chem Biol Drug Des. 2012 Mar;79(3):360-7.
4-(3-(1-(2-(4-(2,4-dimethoxybenzoyl)phenoxy)acetyl)piperidin-4-yl)propyl)-N-(4-fluorophenyl)piperidine-1-carboxamide  0   *Benzophenones *Piperidines. Chem Biol Drug Des. 2012 Mar;79(3):360-7.
1-(amino(oxo)acetyl)-N-(1-(3,5-bis(trifluoromethyl)phenyl)ethyl)-3-(4-fluoro-2-methylphenyl)-N-methylpiperidine-4-carboxamide  0   *Piperidines Receptors, Neurokinin-1/antagonists & inhibitors. Bioorg Med Chem. 2012 Jan 15;20(2):962-77.
N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-oxopiperidine-3-carboxamide  0   *Indoles *Piperidines. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3540-5.
IPR-456  0   *Piperidines *Benzoic Acids. ACS Chem Biol. 2011 Nov 18;6(11):1232-43
5-(4-cyano-3-methylphenyl)-2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)nicotinitrile  0   *Oxadiazoles *Piperidines. Chem Res Toxicol. 2011 Dec 19;24(12):2207-16.
desmethylarzoxifene  0   *Piperidines *Thiophenes. Mol Cell Endocrinol. 2004 May 31;220(1-2):97-107.
5-ethyl-5-(piperidin-1-yl)barbituric acid  0   *Barbiturates *Piperidines. Acta Crystallogr C. 2012 Feb;68(Pt 2):o65-70
5-ethyl-5-(piperidin-1-yl)-1,3-diazinane-2,4,6-trione  0   *Piperidines *Triazines. Acta Crystallogr C. 2012 Feb;68(Pt 2):o65-70
5,5,5-trifluoro-1-(4-(3-thiazol-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)pentan-1-one  0   *Oxadiazoles *Piperidines. J Med Chem. 2012 Jan 12;55(1):68-83.
3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide  0   *Benzamides *Piperidines Calcium Channel Blockers Calcium Channels, T-Type. J Neurophysiol. 2011 Nov;106(5):2653-61.
AZD9164  0   *Piperidines *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. Bioorg Med Chem Lett. Dec 15;21(24):7440-6.
1-(4-benzylpiperidin-1-yl)-2-(6-hydroxy-1H-indol-3-yl)ethane-1,2-dione  0   *Indoles *Piperidines Ligands. J Med Chem. 2011 Dec 22;54(24):8702-6.
2-(4-benzylpiperidin-1-yl)-1-(6-hydroxy-1H-indol-3-yl)ethanone  0   *Indoles *Piperidines Ligands. J Med Chem. 2011 Dec 22;54(24):8702-6.
N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine  0   *Indoles *Piperidines Butyrylcholinesterase Cholinesterase Inhibitors Monoamine Oxidase Inhibitors. J Med Chem. 2011 Dec 22;54(24):8251-70.
2,2,6,6-tetraethylpiperidine nitroxide  0   *Cyclic N-Oxides *Piperidines Manganese. Free Radic Res. 2011 Nov;45(11-12):1325-32.
2-(piperidinoethoxyphenyl)-3-phenyl-2H-benzopyran  0   *Benzopyrans *Piperidines. Mol Cell Endocrinol. 2012 Jan 2;348(1):198-210.
4-((4'-benzylpiperdin-4-yl)amino)-4'-O-demethylepipodophyllotoxin  0   *Piperidines Podophyllotoxin/*analogs & derivatives Topoisomerase II Inhibitors. Cancer Sci. 2012 Jan;103(1):80-7.
4-(4-(4-chlorophenyl)-5-(1,2,3)triazol-2-ylmethyl-4H-(1,2,4)triazol-3-yl)piperidin-1-yl-(3,5-difluorophenyl)methanone  0   *Triazoles *Piperidines Receptors, Vasopressin/antagonists & inhibitors. Eur J Pharmacol. 2011 Nov 30;670(2-3):347-55.
2,3,4,9-tetrahydro-9-(2-hydroxy-3-(1-piperidinyl)propyl)-6-methyl-1H-carbazol-1-one  0   *Carbazoles *Piperidines. Eur J Med Chem. 2011 Nov;46(11):5675-9.
4-(1-((5-((2,6-dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine  0   *Isoxazoles *Piperidines *Pyridines. Nat Chem Biol. 2011 Dec;7(12):891-3
2-(1-benzylpiperidin-4-yl)amino-N-(3-chlorophenyl)nicotinamide  0   *Piperidines Niacinamide/*analogs & derivatives. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6236-41
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine  0   *Dibenzocycloheptenes *Piperidines. J Pharmacol Exp Ther. 2011 Nov;339(2):716-25.
(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)(piperidin-1-yl)methanone  0   *Piperidines *Pyrazoles Receptor, Cannabinoid, CB1/antagonists & inhibitors. Acta Pharmacol Sin. 2011 Sep;32(9):1148-58.
cannabipiperidiethanone  0   *Indoles *Piperidines. Chem Pharm Bull (Tokyo). 2011;59(9):1203-5
galvestine-1  0   *Piperidines. Nat Chem Biol. 2011 Nov;7(11):834-42
SQ 609  0   *Piperidines Adamantane/*analogs & derivatives. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5353-7.
azatrux  0   *Carbazoles *Piperidines. Biochimie. 2011 Aug;93(8):1318-27.
pseudoconhydrine  0   *Piperidines Alkaloids. J Org Chem. 2011 Aug 19;76(16):6844-8
(1-(4-methyl-1-(6-(trifluoromethyl)-3-pyridinyl)pentyl)-2-(4-(trifluoromethyl)phenyl)-4-piperidinyl)acetic acid  0   *Acetic Acids *Piperidines Amyloid Precursor Protein Secretases. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1306-11.
ML 204  0   *Indoles *Piperidines. J Biol Chem 2011 Sep 23;286(38):33436-46
desmethylveramiline  0   *Piperidines Cholesterol/*analogs & derivatives. Bioorg Med Chem Lett 2011 Jun 15;21(12):3608-12
(5-(3,4-dichlorophenyl)furan-2-yl)piperidine-1-ylmethanethione  0   *Piperidines *Thiones. Curr Biol 2011 Jun 7;21(11):990-7
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea  0   *Phenylurea Compounds *Piperidines Epoxide Hydrolases/antagonists & inhibitors. J Cardiovasc Pharmacol 2011 Mar;57(3):273-81
CL-385319  0   *Hydrocarbons, Fluorinated *Piperidines. Eur J Pharmacol. 2011 Jun 25;660(2-3):460-7
GSK 163929  0   *Piperidines *Azabicyclo Compounds Receptors, CCR5/antagonists & inhibitors. J Med Chem 2011 Jun 9;54(11):3756-67
5-bromo-N-(1-(3-fluoro-2-methoxybenzoyl)-5-methylpiperidin-2-yl)methylpyridin-2-amine  0   *Aminopyridines *Piperidines. PLoS One 2011;6(1):e16406
CSI-75  0   *Piperidines *Pyridines. J Autoimmun. 2011 May;36(3-4):201-9
dumetorine  0   *Piperidines Alkaloids. Chemistry. 2011 May 23;17(22):6221-6
4-ethyl 5-(3,4 methylenedioxyphenyl)-2E,4E-pentadienoic acid piperidine  0   *Piperidines. Chem Biol Interact. 2011 Apr 25;190(2-3):84-90
pinidinone  0   *Piperidines. J Nat Prod. 2011 Apr 25;74(4):803-8
epidihydropinidine  0   *Piperidines. J Nat Prod. 2011 Apr 25;74(4):803-8
1-(4-((4-chloro-2-((2-chlorophenyl)(hydroxy)methyl)phenyl)(2,2-dimethylpropyl)amino)-4-oxobutanoyl)piperidine-3-carboxylic acid  0   *Benzhydryl Compounds *Piperidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Bioorg Med Chem 2011 Mar 15;19(6):1930-49
GSK 1004723  0   *Phthalazines *Piperidines Histamine H1 Antagonists. Expert Opin Ther Pat 2011 Mar;21(3):425-9
GSK 835726  0   *Naphthalenes *Piperidines Histamine H3 Antagonists. Expert Opin Ther Pat 2011 Mar;21(3):425-9
1-methyl-2-((3-methyl-4-(4-trifluoromethyl-2-fluoro)phenyl)piperidin-1-ylmethyl)-1H-imidazo(4,5-b)pyridine  0   *Piperidines *Bicyclo Compounds, Heterocyclic Receptors, Metabotropic Glutamate/agonists. J Med Chem 2011 Mar 24;54(6):1724-39
CDy2 compound  0   *Heterocyclic Compounds, 3-Ring *Piperidines. Angew Chem Int Ed Engl. 2011 Mar 14;50(12):2761-3
GSK 525060  0   *Piperazines *Piperidines. Drug Metab Dispos 2011 Mar;39(3):363-72
3-(4-piperidyl)-6-fluoro-1,2-benzisoxazole  0   *Isoxazoles *Piperidines. Eur J Med Chem. 2011 Feb;46(2):704-11
N,N'-bis(5-(1-piperidino)-3-oxapentyl)-1,6-bis(1-piperidinyl)perylene-3,4,9,10-tetracarboxylic diimide  0   *Piperidines Perylene/*analogs & derivatives. J Med Chem 2011 Mar 10;54(5):1140-56
(-)-(2R*,3S*,6S*)-N,2-dimethyl-3-hydroxy-6-(9-phenylnonyl)piperidine  0   *Piperidines. Arch Pharm Res. 2010 Nov;33(11):1735-9
1'-benzyl-3-(2-fluoroethyl)-3H-spiro((2)benzofuran-1,4'-piperidine)  0   *Piperidines *Benzofurans Fluorine Radioisotopes Ligands. Eur J Nucl Med Mol Imaging 2011 Mar;38(3):540-51
xestoproxamine C  0   *Piperidines. J Nat Prod. 2011 Mar 25;74(3):430-40
xestoproxamine B  0   *Piperidines. J Nat Prod. 2011 Mar 25;74(3):430-40
xestoproxamine A  0   *Piperidines. J Nat Prod. 2011 Mar 25;74(3):430-40
dihydrostreptazolin  0   *Piperidines. Nat Prod Commun. 2011 Mar;6(3):353-5
PF 3845  0   *Piperidines *Pyridines. J Lipid Res 2011 Feb;52(2):337-44
1'-benzyl-3-(3-fluoropropyl)-3H-spiro((2)benzofuran-1,4'-piperidine)  0   *Piperidines *Spiro Compounds. Chirality. 2011 Feb;23(2):148-54
4-azido-2,2,6,6-tetramethylpiperidine 1-oxyl  0   *Azides *Piperidines. Chemistry. 2010 Dec 27;16(48):14385-96
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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