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Piperidones

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Definition:      
Examples Cycloheximide; Dexetimide; Glutethimide; Naphthalimides; Thalidomide; Triacetoneamine-N-Oxyl
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl))-3,5-bis-(2-fluorobenzylidene)-4-piperidone  0   *Hydrazines *Piperidones. Chem Biol Drug Des. 2012 Feb;79(2):194-201.
piperarborenine B  0   *Piperidones. J Am Chem Soc. 2011 Nov 30;133(47):19076-9
piperarborenine D  0   *Piperidones. J Am Chem Soc. 2011 Nov 30;133(47):19076-9
3,5-bis(2,4-difluorobenzylidene)-4-piperidone  0   *Benzylidene Compounds *Piperidones. Mol Cancer Ther. 2011 Nov;10(11):2146-56.
A-1048400  0   *Piperidones Analgesics Calcium Channel Blockers. Biochem Pharmacol. 2012 Feb 1;83(3):406-18
3,5-bis((4-nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one  0   *Piperidones Protease Inhibitors. Nat Med. 2011 Dec;17(12):636-40
1,2-bis(3,5-dibenzylidene-4-oxopiperidin-1-yl)ethane-1,2-dione  0   *Benzylidene Compounds *Piperidones. ChemMedChem. 2011 Oct 4;6(10):1892-9.
3-pentyl-2,6-diphenylpiperidin-4-one  0   *Piperidones. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Nov;82(1):260-9
5-bis(4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidone  0   *Benzylidene Compounds *Piperidones. Breast Cancer Res Treat 2011 Jul;128(1):97-107
2,2,6,6-tetramethyl-4-piperidinone  0   *Piperidones. Biochim Biophys Acta. 2011 Mar;1807(3); 243-50
4,4-dimethylpiperidine-2,6-dione  0   *Piperidones. J Phys Chem A. 2010 Dec 16;114(49):12881-7
3-amino-6-hydroxy-2-piperidone  0   *Piperidones. Chem Commun (Camb). 2010 Dec 14;46(46):8857-9
tedanalactam  0   *Lactams *Piperidones. J Org Chem. 2009 Aug 21;74(16):6378-81
N-(1-(cyclopropylmethyl)-2,3-dioxo-3-(2-propenylamino)propyl)-3-(2-((((1-((4,4-dimethyl-2,6-dioxo-1-piperidinyl)methyl)-2,2-dimethylpropyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexane-2-carboxamide  0   *Piperidones Urea/*analogs & derivatives. J Med Chem 2009 Mar 12;52(5):1370-9
cordiarimide B  0   *Piperidones. J Nat Prod. 2010 May 28;73(5):992-4
cordiarimide A  0   *Piperidones. J Nat Prod. 2010 May 28;73(5):992-4
2-(3-(3,5-bis(4-nitrobenzylidene)-4-oxopiperidin-1-yl)-3-oxopropylsulfanyl)ethanesulfonic acid  0   *Piperidones *Sulfonic Acids. Mol Cancer 2009;8:65
1-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin-2-one  0   *Piperidones. Bioorg Med Chem. 2009 Nov 1;17(21):7412-7
3,3,5,5-tetramethyl-4-piperidone  0   *Piperidones. J Ethnopharmacol. 2009 May 4;123(1):34-9
(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)  0   *Piperidones. J Pharmacol Exp Ther 2009 Jun;329(3):959-66
KBH A42  0   *Hydroxamic Acids *Piperidones Histone Deacetylases/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 1;16(15):4068-70
methyl 6-(benzyloxycarbonylamino)-2-(2-(2,6-dioxo-3-(3,4,5-trimethoxybenzamido)piperidin-1-yl)acetamido)hexanoate  0   *Benzamides *Piperidones Matrix Metalloproteinase 2/antagonists & inhibitors Matrix Metalloproteinase 9/antagonists & inhibitors. Anticancer Drugs 2008 Nov;19(10):957-65
1-(4-(2-diethylaminoethoxy)phenylcarbonyl)-3,5-bis (benzylidene)-4-piperidone  0   *Piperidones. Pharmazie. 2008 Nov;63(11):827-9
3,3-tetramethyleneglutarimide  0   *Piperidones. J Phys Chem A. 2008 Oct 9;112(40):10053-8
PHA 767491  0   *Piperidones *Pyrroles. Nat Chem Biol 2008 Jun;4(6):331-2
(3,4-dichlorophenyl)methyl(2-oxo-2-(3-phenyl-2-(1-pyrrolidinylmethyl)-1-piperidinyl)ethyl)amine  0   *Aniline Compounds *Piperidones. Bioorg Med Chem Lett 2008 Jun 15;18(12):3500-3
3,5-bis(3-(4-methoxyphenyl)prop-2-enylidene)-1-methyl-4-piperidone  0   *Piperidones. Acta Crystallogr C. 2008 Feb;64(Pt 2):o73-5
3,5-bis(3-(4-(dimethylamino)phenyl)prop-2-enylidene)-1-methyl-4-piperidone  0   *Piperidones. Acta Crystallogr C. 2008 Feb;64(Pt 2):o73-5
7-(5-ethyl-1,3,4-thiadiazol-2-yl)-9-propyl-7-azaspiro(4,5)decane-6,8-dione  0   *Piperidones *Thiadiazoles. J Med Chem 2007 Nov 29;50(24):6165-76
1-methyl-4-piperidone  0   *Piperidones. Spectrochim Acta A Mol Biomol Spectrosc. 2007 Nov;68(3):845-50
3,5-bis(benzylidene)-4-piperidone  0   *Piperidones. J Chem Inf Model. 2007 Nov-Dec;47(6):2110-23
3,5-bis(2-fluorobenzylidene)piperidin-4-one  0   *Benzylidene Compounds *Piperidones. J Biol Chem Sep 28;292(39):28609-18
1-chloro-3-methyl-2,6-diphenylpiperidin-4-one  0   *Piperidones. J Org Chem 2007 Jul 6;72(14):5327-36
1-benzyl-4-piperidone  0   *Benzyl Compounds *Piperidones. Org Lett 2007 Apr 12;9(8):1505-8
M58163  0   *Naphthalenes *Piperidones *Spiro Compounds. Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1535-44
M58169  0   *Naphthalenes *Piperidones *Spiro Compounds. Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1535-44
spiro(imidazo(1,2-a)pyrazine-2(3H),4'-piperidin)-5(1H)-one  0   *Piperidones *Spiro Compounds. Chem Pharm Bull (Tokyo). 2006 Nov;54(11):1535-44
NSC 632839  0   *Piperidones. Cancer Res 2006 Sep 15;66(18):9235-44
S632A3  0   *Piperidones. J Asian Nat Prod Res. 2006 Jan-Mar;8(1-2):55-60
cis-5-hydroxy-3-phthalimidoglutarimide  0   *Phthalimides *Piperidones. J Org Chem. 2005 Nov 25;70(24):10117-120
1-(4-(4-chinolin-2-yl-piperazin-1yl)-butyl)piperidin-2-one  0   *Piperidones *Piperazines. J Pharm Pharmacol. 2005 Feb;57(2):205-11
5-methoxy-3-sulfonyl glutarimide  0   *Piperidones. J Org Chem. 2005 Mar 4;70(5):1780-5
3,5-bis(4-(diethylamino)cinnamylidene)-1-methyl-4-piperidone  0   *Aniline Compounds *Piperidones. Acta Crystallogr C 2003 Nov;59(Pt 11):o605-8
3,5-bis(4-(diethylamino)benzylidene)-1-methyl-4-piperidone  0   *Aniline Compounds *Piperidones. Acta Crystallogr C 2003 Nov;59(Pt 11):o605-8
dimethylpiperidone  0   *Piperidones. Drug Chem Toxicol. 2004 Feb;27(1):1-14
dihydropiplartine  0   *Piperidones Plant Extracts. Phytochem Anal. 2003 Sep-Oct;14(5):281-4
piplartine  0   *Piperidones Plant Extracts. Phytochem Anal 2003 Sep-Oct;14(5):281-4
5-hydroxygepirone  0   *Piperidones *Pyrimidines. Biopharm Drug Dispos 2003 Mar;24(2):87-94
2-hydroxygepirone  0   *Piperidones *Pyrimidines. Biopharm Drug Dispos 2003 Mar;24(2):87-94
3'-hydroxygepirone  0   *Piperidones *Pyrimidines. Biopharm Drug Dispos 2003 Mar;24(2):87-94
1,5-dimethyl-2-piperidinone  0   *Piperidones. Toxicology 2003 Feb 1;183(1-3):1-13
1,3-dimethyl-2-piperidinone  0   *Piperidones. Toxicology 2003 Feb 1;183(1-3):1-13
1-benzyloxycarbonyl-2-(2'-phenylethenyl)-4-piperidone  0   *Piperidones. J Org Chem 2002 Mar 22;67(6):1972-3
N,N'-bis(3-(4-morpholino)propyl)-3,4,9,10-perylenetetracarboxylic acid diimide  0   *Piperidones Perylene/*analogs & derivatives. Bioorg Med Chem Lett 2002 Feb 11;12(3):447-50
isomigrastatin  0   *Piperidones *Macrolides. J Antibiot (Tokyo) 2002 Feb;55(2):141-6
3-(undec-10-enoylamino)glutarimide  0   *Piperidones. J Med Chem 2002 Jan 17;45(2):360-70
indigoidine  2435-59-8   *Piperidones. J Bacteriol 2002 Feb;184(3):654-65
sulphostin  0   *Organophosphorus Compounds *Piperidones.
Pharma Action Dipeptidyl-Peptidase IV Inhibitors 		J Antibiot (Tokyo) 2001 Sep;54(9):744-6
julocrotine  0   *Alkaloids *Piperidones. Fitoterapia 2000 Aug;71(4):461-2
migrastatin  0   *Piperidones *Macrolides. J Antibiot (Tokyo) 2000 Oct;53(10):1130-6
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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