Definition: Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.
an enzyme precursor & fibrinolytic agent; /antag: do not confuse with PLASMINOGEN INACTIVATORS which modulate PLASMINOGEN ACTIVATORS, not PLASMINOGEN
Pharmacological ActionFibrinolytic Agents ExamplesAngiostatins