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Plasticizers

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Definition: Materials incorporated mechanically in plastics (usually PVC) to increase flexibility, workability or distensibility; due to the non-chemical inclusion, plasticizers leach out from the plastic and are found in body fluids and the general environment.     
Substances having this pharmacologic action: Dibutyl Phthalate; Diethylhexyl Phthalate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
poly(propylene adipate)  25101-03-5   *Adipic Acids *Polypropylenes Plasticizers Polymers. Food Addit Contam 1993 Sep-Oct;10(5):523-9
poly(4-phenylene terephthalamide)  0   *Phthalic Acids *Polymers Plasticizers. Shika Zairyo Kikai 1990 Jan;9(1):1-10
dofen  114265-20-2   Organic Chemicals Plasticizers. Gig Sanit 1991(3):25
butyryl-n-trihexylcitrate  82469-79-2   *Butyric Acids Plasticizers. Transfusion 1991;31(1):26
N-butylbenzenesulfonamide  3622-84-2   *Sulfonamides Plasticizers. Lancet 1990;336(8715):640
dibutyl sebacate  109-43-3   *Dicarboxylic Acids Plasticizers. Food Addit Contam 1988;5(1):9
softic 49  0   *Methacrylates Denture Liners Plasticizers. J Prosthet Dent 1987;57(4):507
diisononyl adipate  33703-08-1   *Adipic Acids Plasticizers. Environ Mutagen 1986;8(6):817
santicizer 148  96300-95-7   *Organophosphorus Compounds Plasticizers. Fundam Appl Toxicol 1986;7(1):138
butyl phthalyl butyl glycolate  85-70-1   Dibutyl Phthalate/*analogs & derivatives Plasticizers Tissue Conditioning (Dental). J Dent Res 1986;65(5):634
tert-butylphenyl diphenyl phosphate  56803-37-3   *Phosphoric Acid Esters Air Pollutants, Occupational Plasticizers. Appl Environ Microbiol 1985;50(2):265
diisodecyl phthalate  26761-40-0   *Phthalic Acids Plasticizers. Arch Phys Med Rehabil 1984;65(8):467
tri-(2-ethylhexyl)trimellitate  3319-31-1   *Benzoates Plasticizers. Vox Sang 1982;43(4):223
trioctyl trimellitate  89-04-3   *Benzoates Plasticizers. JPEN 1982;6(1):64
2-ethylhexanol  104-76-7   *Hexanols Plasticizers. Toxicol Lett 1982;10(4):379
tri-xylenyl phosphate  25155-23-1   *Organophosphorus Compounds Plasticizers. J Soc Occup Med 1981;31(2):69
butylbenzyl phthalate  85-68-7 1,2-Benzenedicarboxylic acid, butyl phenylmethyl ester  *Phthalic Acids Plasticizers.
Pharma Action Teratogens 		Toxicol Lett 1980;6(6):373
di-n-hexyl phthalate  84-75-3   *Phthalic Acids Plasticizers. Bull Environ Contam Toxicol 1980;25(3):345
DAF-789  57657-08-6 DAF 789  Diethylhexyl Phthalate/*analogs & derivatives Plasticizers. Gig Sanit 1980;6:35
dibutyl phenylphosphate  2528-36-1 phosphoric acid, dibutyl phenyl ester  *Phosphoric Acid Esters Plasticizers. Radiobiologiia 1980;20(4):623
tri-o-cresyl phosphate  78-30-8 phosphoric acid, tris(2-methylphenyl) ester  *Tritolyl Phosphates Plasticizers. Toxicol Appl Pharmacol 1980;53(3):439
dimethyl phthalate  131-11-3 1,2-benzenedicarboxylic acid, dimethyl ester  *Phthalic Acids Plasticizers.
Pharma Action Fixatives ; Insect Repellents 		Med Parazitol (Mosk) 1980;49(1):58
2-acetyltributylcitrate  77-90-7   *Citrates Plasticizers. Gig Sanit 4:102;1977
dioctyl adipate  103-23-1 di-2-ethylhexyl adipate  *Adipic Acids Plasticizers. J Occup Med 19(3):190;1977
tris(2-butoxyethyl) phosphate  78-51-3 2-butoxyethanol phosphate (3:1)  *Organophosphorus Compounds Plasticizers Water Pollutants, Chemical. Clin Pharmacol Ther 22(5 Pt 1):539;1977; Lancet 2(7992):963;1976
butylene glycol adipic acid polyester  52012-76-7   *Butylene Glycols *Polymers Plasticizers. Toxicol Appl Pharmacol 26(1):58;1973
triphenyl phosphate  115-86-6 phosphoric acid, triphenyl ester  *Phosphoric Acid Esters Plasticizers. Gig Sanit 39(8):98;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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