encyclopedia of medical concepts
ψ 

Platelet Aggregation Inhibitors

More information in Books or onNLM PubMed
Definition: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.  DF: PLATELET INHIB    Other names Platelet Antiaggregants; Platelet Antagonists; Antiplatelet Agents; Antiaggregants, Platelet; Inhibitors, Platelet Aggregation; Inhibitors, Platelet; Drugs, Antiplatelet; Antiaggregants, Blood Platelet; Antagonists, Platelet; Antagonists, Blood Platelet; Aggregation Inhibitors, Platelet; Agents, Antiplatelet; Platelet Inhibitors; Blood Platelet Antiaggregants; Blood Platelet Antagonists; Blood Platelet Aggregation Inhibitors; Antiplatelet Drugs
Substances having this pharmacologic action: enfenamic acid; indobufen; diadenosine tetraphosphate; anagrelide; 12-HPETE; cilostamide; S-nitrosocysteine; glycocalicin; pycnogenols; thromboxane A2, carbocyclic; 8-chlorocarbochromen; carboprostacyclin; fibrinopeptides gamma; oxophenylarsine; andrographolide; argatroban; S-nitrosomercaptoethanol; 3,4-dihydroxyacetophenone; 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate; eicosapentaenoic acid ethyl ester; Quin2; ataprost; dauricine; trequinsin; defibrotide; ibudilast; CV 3988; dazmegrel; piroximone; sulotroban; rosmarinic acid; 9-O-methanoprostaglandin I; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; diallyl trisulfide; N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine; 1,2-dipalmitoyl-3-phosphatidylethanolamine; Milrinone; canadine; protopine; S-Nitrosothiols; S-Nitrosoglutathione; sevoflurane; helenalin; 3-morpholino-sydnonimine; trilinolein; magnolol; 6-methyl-2-ethyl-3-hydroxypyridine; 3,4-dihydroxyphenylethanol; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole; Iloprost; acetylsalicylic acid lysinate; Alprostadil; Aspirin; Epoprostenol; Ticlopidine; Trapidil; Disintegrins; Pentoxifylline; Dipyridamole; Ketanserin; essential 303 forte; picotamide; tranilast; 1,2-benzisothiazoline-3-one; triflusal; plafibride; 3-n-butylphthalide; aloxistatin; xemilofiban; E 4021; sibrafiban; nitroaspirin; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; jararhagin; tirofiban; ifetroban; IH 764-3; policosanol; relcovaptan; GEA 3162; lamifiban; DMP 728; abciximab; eptifibatide; DX 9065a; BN 50730; TCV 309; mexidol; triflavin; rhodostomin; draflazine; SR 46349B; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione; vapiprost; ridogrel; ST 638; FK 409; ramatroban; 1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole; bepafant; efegatran; sarpogrelate; naftopidil; Ro 31-7549; Ro 31-8220; N-acetylsphingosine; KW 3635; acetylphenylalanyl-prolyl-boroarginine; Satigrel; clopidogrel; 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP; RS 5186; S 145; clentiazem; echistatin; BW A868C; inositol 1,2,6-triphosphate; resveratrol; UD CG 212 Cl; beraprost; ajoene; glycyl-arginyl-glycyl-aspartyl-serine; 1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3H)-one; alpha-pentyl-3-(2-quinolinylmethoxy)benzenemethanol; ONO 3708; daltroban; WEB 2086; tautomycin; cilostazol; arginyl-glycyl-aspartyl-serine; aspirin, dipyridamole drug combination
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methyl 6-nitroarachidonate  0   *Arachidonic Acids Platelet Aggregation Inhibitors Vasodilator Agents. Free Radic Biol Med 2011 Feb 1;50(3):411-8
batifiban  0   *Peptides, Cyclic Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Huazhong Univ Sci Technolog Med Sci. 2009 Feb;29(1):12-8
jerdostatin, Protobothrops jerdonii  0   *Disintegrins Platelet Aggregation Inhibitors Recombinant Proteins. Toxicon. 2010 Nov;56(6):1052-8
P2y12 protein, rat  0   *Receptors, Purinergic P2 Platelet Aggregation Inhibitors.
OPC 29030  0   *Imidazoles *Quinolones Sulfur Compounds Platelet Aggregation Inhibitors. Br J Pharmacol 1999 Dec;128(8):1699-704; Circulation. 1998 Dec 22-29;98(25):2891-8
N(9)-imidazo-(1,2)-benzimidazol  0   *Imidazoles Antioxidants Platelet Aggregation Inhibitors. Eksp Klin Farmakol 1999 Jan-Feb;62(1):38-40
SR 121566  0   *Benzylamines *Piperidines *Thiazoles Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. Blood Coagul Fibrinolysis 1997 Apr;8(3):206-7
SDZ GPI 562  0   *Benzylamines Platelet Aggregation Inhibitors Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors. J Clin Invest. 1998 Oct 1;102(7):1301-10; Transplant Proc 1996 Apr;28(2):703
placetin B1  128768-10-5   Streptomyces Platelet Aggregation Inhibitors. J Antibiot (Tokyo) 1990;43(4):331
placetin B  128768-11-6   Streptomyces Platelet Aggregation Inhibitors. J Antibiot (Tokyo) 1990;43(4):331
placetin A1  128768-08-1   Streptomyces Platelet Aggregation Inhibitors. J Antibiot (Tokyo) 1990;43(4):331
placetin A  128768-09-2   Streptomyces Platelet Aggregation Inhibitors. J Antibiot (Tokyo) 1990;43(4):331
troglitazone  97322-87-7 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)  *Chromans *Thiazolidinediones Antineoplastic Agents Fibrinolytic Agents Platelet Aggregation Inhibitors Vasodilator Agents.
Pharma Action Hypoglycemic Agents 		Diabetes 1988;37(11):1549PRELAY; REZULIN
epinastine  80012-43-7   *Dibenzazepines *Imidazoles Platelet Aggregation Inhibitors.
Pharma Action Histamine H1 Antagonists 		Arzneimittelforschung 1987;37(5):569ELESTAT; EPINASTINE HYDROCHLORIDE
nebivolol  99200-09-6   *Benzopyrans *Ethanolamines Nitric Oxide Platelet Aggregation Inhibitors.
Pharma Action Antihypertensive Agents ; Vasodilator Agents ; Adrenergic beta-1 Receptor Antagonists 		Angiology 1987;38(6):440BYSTOLIC
rutecarpine  84-26-4   *Quinazolines *Indole Alkaloids Cardiotonic Agents Platelet Aggregation Inhibitors Rutaceae.
Pharma Action Vasodilator Agents 		J Nat Prod 1980;43(5):577
azelastine  58581-89-8   *Phthalazines Anti-Inflammatory Agents, Non-Steroidal Platelet Aggregation Inhibitors.
Pharma Action Bronchodilator Agents ; Lipoxygenase Inhibitors ; Anti-Allergic Agents ; Histamine H1 Antagonists, Non-Sedating 		Arzneim Forsch 29(3):488;1979ASTELIN; AZELASTINE HYDROCHLORIDE; DYMISTA; ASTEPRO; OPTIVAR
tetramethylpyrazine  1124-11-4   *Pyrazines Adrenergic beta-Agonists Anti-Inflammatory Agents, Non-Steroidal Calcium Channel Blockers Fibrinolytic Agents Platelet Aggregation Inhibitors Ligusticum.
Pharma Action Vasodilator Agents 		Chin Med J (Engl) 4(4):319;1978; J Chromatogr A. 2004 Aug 27;1047(2):249-53; Life Sci 2005 Nov 26;78(2):128-133; Planta Med 1980;38(2):144; Planta Med 1980;38(4):332; Yao Hsueh Hsueh Pao 1979;14(10):624
nimesulide  51803-78-2 methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)  *Sulfonamides Calcium Channel Blockers Platelet Aggregation Inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Cyclooxygenase Inhibitors 		Arch Int Pharmacodyn Ther 221(1):132;1976; Arch Int Pharmacodyn Ther 238(2):344;1979; Biochem Pharmacol 26(4):307;1977; Ginekol Pol 50(4):299;1979; J Pharm Sci 66(12):1700;1977
ifenprodil  23210-56-2 alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine ethanol  *Piperidines Anticonvulsants Antiparkinson Agents Platelet Aggregation Inhibitors Receptors, N-Methyl-D-Aspartate.
Pharma Action Adrenergic alpha-Antagonists ; Vasodilator Agents ; Excitatory Amino Acid Antagonists 		Ann Otolaryngol Chir Cervicofac 95(10-11):719;1978; Arch Jpn Chir 46(2):135;1977; Biochem Pharmacol 1979;28(24):3503; Folia Pharmacol Jpn 70(6):785;1975; Folia Pharmacol Jpn 71(5):517;1975; Folia Pharmacol Jpn 71(6):585-97;1975; Folia Pharmacol Jpn 71(7):709;1975; Folia Pharmacol Jpn 72:185;1976; Folia Pharmacol Jpn 73(5):517;1977; Folia Pharmacol Jpn 74(2):303;1978; J Gynecol Obstet Biol Reprod (Paris) 1979;8(3):261; Jpn J Pharmacol 26(3):391;1976; Jpn J Pharmacol 27:470;1977; Toxicol Appl Pharmacol 1979;49(2):209; Toxicol Appl Pharmacol 37(2):289;1977
buflomedil  55837-25-7 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone  *Pyrrolidines Adrenergic alpha-Antagonists Platelet Aggregation Inhibitors.
Pharma Action Vasodilator Agents 		Sem Hop Paris 1980;56(9-10):490; Therapie 30(2):207;1975; Therapie 30(2):259;1975; Therapie 33(3):321;1978

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy