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Adenomatous Polyposis Coli

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Definition: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood. The lifetime risk of colorectal cancer in these patients reaches 100 percent by age 60.     
See Also Adenomatous Polyposis Coli Protein; Gardner Syndrome; Genes, APC
Examples Gardner Syndrome 		Other names Polyposis Syndrome, Familial; Polyposis Coli, Familial; Coli, Hereditary Polyposis; Coli, Familial Polyposis; Coli, Adenomatous Polyposis; Adenomatous Polyposis, Familial; Adenomatous Polyposis Colus; Adenomatous Polyposes, Familial; Adenomatous Intestinal Polyposis; Adenomatous Intestinal Polyposes; Polyposis, Adenomatous Intestinal; Hereditary Polyposis Coli; Familial Polyposis of the Colon; Familial Polyposis Coli; Familial Multiple Polyposi; Familial Intestinal Polyposis; Familial Adenomatous Polyposis of the Colon; Familial Adenomatous Polyposis Coli; Familial Adenomatous Polyposis; Adenomatous Polyposis of the Colon
 
SubstanceCAS Registry & nameCategoriesSource
Attenuated familial adenomatous polyposis  0   *Adenomatous Polyposis Coli.
Desmoid disease, hereditary  0   *Abdominal Neoplasms *Adenomatous Polyposis Coli *Fibromatosis, Aggressive.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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