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Pregnadienes

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Definition: Pregnane derivatives containing two double bonds anywhere within the ring structures.     
Examples Canrenoate Potassium; Canrenone; Chlormadinone Acetate; Cyproterone; Danazol; Dydrogesterone; Fluocinolone Acetonide; Medrogestone; Megestrol; Melengestrol Acetate; Pregnadienediols; Pregnadienetriols; Triamcinolone
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pregna-5,20-dien-3-O-alpha-fucopyranoside  0   *Pregnadienes *Glycosides. J Asian Nat Prod Res. 2006 Jun;8(4):287-91
3-hydroxy-5,16-pregnadien-20-one  0   *Pregnadienes. Mol Endocrinol 2002 Jul;16(7):1590-7
SC 17599  0   *Pregnadienes. Eur J Pharmacol 2000 Apr 28;395(2):121-8
N-butyl-N-methyl-11-(3'-hydroxy-21'-17'-carbolactone-19'-nor-17' -pregna-1',3',5'(10')-trien-7'-yl)-undecanamide  0   *Pregnadienes 17-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Eur J Med Chem 2000 Feb;35(2):217-25
methyl 21-desoxy-21-chloro-11-hydroxy-3,20-dioxo-1,4-pregnadiene-16-carboxylate  0   *Pregnadienes. Steroids 2000 Apr;65(4):210-8
methyl 21-desoxy-21-chloro-11,17-dihydroxy-3,20-dioxo-1,4-pregnadiene-16-carboxylate  0   *Pregnadienes. Steroids 2000 Apr;65(4):210-8
pregna-1,4-dien-3-on-20-al  0   *Pregnadienes. Biosci Biotechnol Biochem 1998 Nov;62(11):2182-8
20-hydroximino-4,16-pregnadien-3-one  0   *Imines *Pregnadienes. Bioorg Med Chem 1998 Oct;6(10):1683-93
4,16-pregnadiene-3,20-dione-20-oxime acetate  0   *Oximes *Pregnadienes. Bioorg Med Chem 1998 Oct;6(10):1683-93
pregna-4,20-diene-3,6-dione  0   *Pregnadienes. J Steroid Biochem Mol Biol 1998 Apr;65(1-6):237-42
icometasone enbutate  103466-73-5   *Pregnadienes. Arzneimittelforshung 1998 Apr;48(4):371-8
20-(N,N-dimethylamino)-3--(2-methyl-2-butenamido)pregna-5,14-dien-4-one  0   *Pregnadienes. Phytochemistry 1997 Oct;46(4):771-5
20-succinamylpregna-1,4-dien-3-one  134332-55-1   *Pregnadienes. Steroids 1991;56(4):189
17-benzoyloxy-11-hydroxy-3,20-dioxo-1,4-pregnadien-21-al hemiacetal  130399-79-0   *Pregnadienes. J Pharm Sci 1990;79(5):373
Ro 14-9012  76225-44-0   *Pregnadienes. J Pharm Sci 1985;74(9):972
12-hydroxy-3-oxo-1,4-pregnadiene-20-carboxylic acid  78962-23-9   *Pregnadienes. J Steroid Biochem 1985;22(6):817
oxyma  57361-81-6 Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo  *Pregnadienes. Arch Androl 1984;13(1):59
domoprednate  66877-67-6   *Pregnadienes. Dermatologica 1985;170(4):189
3 alpha-hydroxy-5 alpha-pregna-9(11),16-diene-20-one  38393-04-3   *Pregnadienes. Steroids 1984;43(5):491
nivazol  24358-76-7   *Pregnadienes. Endocrinology 1984;114(6):1983
3-hydroxy-5,7-pregnadien-20-one  81968-78-7 Pregna-5,7-dien-20-one, 3-hydroxy-, (3beta)  *Pregnadienes. FEBS Lett 1983;153(1):161
Ro 12-2503  81844-75-9 3'H-Cyclopropa(6,7)-D-homopregna-4,6,16-triene-21-carboxylic acid, 6,7-dihydro-17a-hydroxy-3-oxo-, (6alpha,7alpha,17aalpha)  *Pregnadienes. Arzneimittelforsch 1982;32(2):164
20-carboxy-1,4-pregnadien-3-one  20248-18-4   *Pregnadienes. Z Allg Mikrobiol 1981;21(4):289
21-hydroxypregna-1,4-diene-3,11,20-trione  67067-81-6 Pregna-1,4-diene-3,11,20-trione, 21-hydroxy  *Pregnadienes. Steroids 31(4):573;1978
5 alpha-pregna-1,20-diene-3-one  0   *Pregnadienes. Steroids 30(3):379;1977; Steroids 30(3):389;1977
rimexolone  49697-38-3 (11 beta,16 alpha,17 beta)-11-hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one  *Pregnadienes.
Pharma Action Glucocorticoids 		Arzneim Forsch 1980;30(1):55; J Pharm Pharmacol 28 Suppl:82;1976VEXOL
Ro 6-1963  4136-08-7 6 beta methoxy-9 beta,10 alpha-pregna-4,6-dien-3,20-dione  *Pregnadienes 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Experientia 32(10):1250;1976
GR 2-1159  24432-00-6 17-acetoxy-6,11 beta-dichloro-19-nor-4,6-pregnadiene-3,20-dione  *Pregnadienes Progestins. Steroids 23(3):425;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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