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Pregnancy-Associated Plasma Protein-A

More information in Books or onNLM PubMed
Definition: A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.      Other names PAPP-A; Protease, IGFBP-4; Pregnancy Associated Plasma Protein A; PAPP alpha; Metalloproteinase, IGFBP-4; Insulin Like Growth Factor Dependent IGF Binding P; Insulin Like Growth Factor Binding Protein 4 Prote; IGFBP 4 Protease; IGFBP 4 Metalloproteinase; Pregnancy-Associated alpha-Plasma Protein; Pregnancy Associated alpha Plasma Protein; Insulin-Like-Growth Factor Binding Protein-4 Prote; Insulin-Like Growth Factor-Dependent IGF Binding P; IGFBP-4-Specific Proteinase; IGFBP-4 Protease; IGFBP-4 Metalloproteinase; PAPP-alpha
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PAPPA2 protein, mouse  EC 3.4.24.-   *Pregnancy-Associated Plasma Protein-A. Genetics 2006 Jul;173(3):1547-53
PAPPA2 protein, human  EC 3.4.-   *Pregnancy-Associated Plasma Protein-A Blood Proteins. J Biol Chem 2001 Jun 15;276(24):21849-53

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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