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Pregnenediones

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Definition: Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.     
Examples Aldosterone; Budesonide; Corticosterone; Cortodoxone; Desoxycorticosterone; Flurandrenolone; Flurogestone Acetate; Gestonorone Caproate; Halcinonide; Hydrocortisone; Progesterone 		Other names Dioxopregnenes; Diketopregnenes
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-cyclohexanecarboxylate 17-cyclopropanecarboxylate  0   *Pregnenediones. J Pharmacol Sci 2010 Jan;112(1):73-82
GG-50B compound  0   *Pregnenediones. Lab Invest 2010 Jul;90(7):1004-15
4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate)  0   *Pregnenediones. J Med Chem 2009 Nov 26;52(22):7122-31
5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione  0   *Pregnenediones. Steroids. 2009 Feb;74(2):229-32
ciclesonide M1  0   *Pregnenediones. J Chromatogr B Analyt Technol Biomed Life Sci 2008 Jun 15;869(1-2):84-92
desisobutyrylciclesonide  0   *Pregnenediones. Drugs 2004;64(5):511-9
17-(5-chlorovaleroyloxy)-16-methylpregna-4,6-diene-3,20-dione  0   *Pregnenediones. Anal Sci 2003 Apr;19(4):639-40
4-bromo-17alpha-(p-fluorobenzoyloxy)-4-pregnene-3,20-dione  0   *Pregnenediones. Proc West Pharmacol Soc 2002;45:164-5
3-acetoxypregna-5,16-diene-20-one  0   *Pregnenediones. Lett Appl Microbiol 2002;35(2):95-7
17-hexanoyloxy-16-methylpregn-4,6-diene-3,20-dione  0   *Pregnenediones. Anal Sci 2001 Oct;17(10):1245-6
7-(4'-(N-alpha-methylbenzylaminoacylaminophenyl)thio)pregna-4-ene-3,20-dione  0   *Pregnenediones.
ciclesonide  141845-82-1   *Pregnenediones.
Pharma Action Anti-Allergic Agents 		Am J Respir Crit Care Med 1999 Jul;160(1):237-43ALVESCO; ZETONNA; OMNARIS
pregn-4-en-3,6,20-trione  0   *Pregnenediones. Steroids 1998 Feb;63(2):76-9
cholest-4-en-3,6-dione  984-84-9   *Pregnenediones. Steroids 1998 Feb;63(2):76-9
L 685273  0   *Pregnenediones 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/antagonists & inhibitors. Endocrinology 1996 Jul;137(7):2703-10
18-(diazomethyl)pregn-4-ene-3,18,20-trione  0   *Pregnenediones. J Med Chem 1996 Jul 5;39(14):2860-4
18-(diazomethyl)-20-hydroxypregn-4-ene-3,18-dione  0   *Pregnenediones. J Med Chem 1996 Jul 5;39(4):2860-4
21-diazopregn-4-ene-3,20-dione  53892-00-5   *Pregnenediones. J Med Chem 1996 Jul 5;39(14):2860-4
norgestomet  25092-41-5 19-norpregn-4-ene-3,20-dione, 17-(acetyloxy)-11-methyl-, (11-beta)  *Pregnenediones Progesterone Congeners. Reprod Nutr Dev 1985;25(6):1029
medrysone  2668-66-8   *Pregnenediones.
Pharma Action Glucocorticoids 		Invest Ophthalmol Vis Sci 1983;24(2):147HMS
16,17-(1'-(4-azidophenyl)ethylidenedioxy)pregn-4-ene-3,20-dione  0   *Pregnenediones. Bioconj Chem 1995 Jan-Feb;6(1):115-22
(1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione  147151-82-4   *Pregnenediones Fluorine Radioisotopes. J Med Chem 1993 Apr 30;36(9):1111-9
Org 5933  72137-42-9 19-Norpregna-4,9-diene-3,20-dione, 16-ethyl-21-hydroxy-, (16alpha)  *Pregnenediones Progestins. J Reprod Fertil 1993 Jan;97(1):39-49
butixocort 21-propionate  98449-05-9 Pregn-4-ene-3,20-dione, 11-hydroxy-17-(1-oxobutoxy)-21-((1-oxopropyl)thio)-, (11beta)  *Pregnenediones. Drug Metab Dispos 1991;19(2):546
21-deacetyldeflazacort  13649-57-5   *Pregnenediones. Br J Clin Pharmacol 1986;21(2):125
16 alpha-ethyl-19-nor-4-pregnene-3,20-dione-21-al  92278-27-8 19-Norpregn-4-en-21-al, 16-ethyl-3,20-dioxo-, (16alpha)  *Pregnenediones. J Chromatogr 1984;297:301
Syncro-Mate B  0   *Pregnenediones Drug Combinations Estradiol/*analogs & derivatives. J Anim Sci 1983;57(2):418
ORG 2058 affinity resin  84013-72-9 Agarose, 19-((16alpha,17beta)-16-ethyl-3-oxoestr-4-en-17-yl)-2,7,10,19-tetraoxo-14,15-dithia-3,6,11,18-tetrazanonadec-1-yl ether  *Pregnenediones *Resins, Synthetic Chromatography, Affinity. Eur J Biochem 1982;128(1):249
16-alpha-ethyl-21-hydroxy-19-norpreg-4-ene-3,20-dione dodecanoate  67490-00-0 16-alpha-Ethyl-21-((1-oxododecyl)oxy)-19-norpregn-4-ene-3,20-dione  *Pregnenediones Progesterone Congeners. Contraception 1982;25(6):551
maxicortex 2000  0   *Pregnenediones Drug Combinations Adrenal Cortex Hormones. Minerva Med 1981;72(2):91
pregna-4,17-diene-3,16-dione  95975-55-6 (17E)-pregna-4,17(20)-diene-3,16-dione  *Pregnenediones Commiphora. Planta Med 1979;37(4):367
deflazacort  14484-47-0 (11 beta,16 beta)-21-(acetyloxy)-11-hydroxy-2'- methyl-5'H-pregna-1,4-dieno(17,16-d)oxazole-3,20- dione  *Pregnenediones.
Pharma Action Anti-Inflammatory Agents ; Immunosuppressive Agents 		Drug Metab Disp 7(5):335;1979
16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione  24320-06-7 (16 alpha)-16-ethyl-21-hydroxy-19-norpregn- 4-ene-3,20-dione  *Pregnenediones Progesterone Congeners. Biochim Biophys Acta 585(1):24;1979; Eur J Cancer 1979;15(10):1181; Eur J Cancer 1979;15(5):785; J Endocrinol 80(2):15P;1979
21-amino-5-pregnene-3,20-dione bisethylene ketal  0   *Pregnenediones. Steroids 30(6):719;1977
17,21-dihydroxy-11-oxa-4-pregnene-3,20-dione  60009-90-7 11-Oxapregn-4-ene-3,20-dione, 17,21-dihydroxy  *Pregnenediones. Steroids 27(5):717;1976
DU 41165  34184-58-2 6-fluoro-17-hydroxy-15-methylene-9 beta,10 alpha- pregna-4,6-diene-3,20-dione acetate  *Pregnenediones Progesterone Congeners. Acta Endocrinol 82(1):193;1976
cloprednol  5251-34-3 6-chloro-11 beta, 17 alpha, 21-trihydroxypregn-1,4,6-triene- 3,20-dione  *Pregnenediones. Annals Allergy 40(6):376;1978; Br J Clin Pharm 6(1):91;1978; J Clin Pharmacol 16(2-3):122;1976; J Clin Pharmacol 1979;19(10):675; J Internat Med Res 4:326;1976; J Pharm Sci 67(7):920;1978; JAMA 1979;242(24):2679; Pediatrics 63(5):747;1979; Respiration 1979;38(6):345
ORF 10703  58212-88-7 Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, cyclic 3-(1,2-ethanediyl mercaptole), (6alpha,11beta,16alpha)  *Pregnenediones. Arthritis Rheum 18(5):519;1975
edogestrone  809-01-8 17-hydroxy- 6-methylpregn-5-ene-3,20-dione cyclic 3-(ethylene acetal) acetate  *Pregnenediones Progesterone Congeners. Acta Endocrinol 75(2):385;1974
DU 41164  34542-22-8 6-fluoro-17-hydroxy-1 beta,2-methylene-9 beta,10- alpha-pregna-4,6-diene-3,20-dione 17-acetate  *Pregnenediones Progesterone Congeners. Acta Endocrinol 82(1):193;1976; Steroids 23(6):909;1974
SQ 20811  630-44-4 21-chloro-11 beta,16 alpha,17 alpha-trihydroxypregn-4-ene-3,20-dione, 16,17-acetonide  *Pregnenediones. Curr Ther Res 16(7):748;1974; J Investig Dermatol 66(3):157;1976
17-hydroxypregnenedione  641-80-5 17 alpha-hydroxypregn-5-ene-3,20-dione  *Pregnenediones.
clomegestone acetate  424-89-5 6-chloro-17-acetoxy-16 alpha-methylpregna-4,6- diene-3,20-dione  *Pregnenediones Progesterone Congeners. J Obstet Gynaecol Br Commonw 78(10):930;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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