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Preservatives, Pharmaceutical

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Definition: Substances added to pharmaceutical preparations to protect them from chemical change or microbial action. They include ANTI-BACTERIAL AGENTS and antioxidants.  D25-26 qualif; DF: PRESERVATIVES PHARM   
See Also Antioxidants 		Other names Pharmaceutic Aids (Preservatives); Preservatives, Pharmaceutic; Preservative, Pharmaceutical; Preservative, Pharmaceutic; Pharmaceutical Preservatives; Pharmaceutical Preservative; Pharmaceutic Preservatives; Pharmaceutic Preservative
Substances having this pharmacologic action: 1,2-dibromo-2,4-dicyanobutane; propylparaben; Chlorobutanol; Thimerosal; Parabens; Benzalkonium Compounds; Phenylethyl Alcohol; methylparaben
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PAS-2 salt solution  0   *Acetates *Citrates *Sodium Chloride Preservatives, Pharmaceutical. Transfus Med 2001 Apr;11(2):105-10
polyaminopropylbiguanide  0   *Biguanides Preservatives, Pharmaceutical. Cornea 1990;9 Suppl 1:S44
4,5-dichloro-2-methyl-4-isothiazolin-3-one  26542-23-4   *Thiazoles Preservatives, Pharmaceutical. Contact Dermatitis 1989;20(3):219
Kathon 886  55965-84-9   *Thiazoles Patch Tests Preservatives, Pharmaceutical.
Pharma Action Mutagens 		Mutat Res 1983;119(1):35
tsolipk 7b  60318-53-8   Organic Chemicals Preservatives, Pharmaceutical. Probl Gematol Pereliv Krovi 24(10):44;1979
quaternium-15  4080-31-3   Methenamine/*analogs & derivatives Preservatives, Pharmaceutical. Cutis 22(6):655;1978
1,2-benzisothiazoline-3-one  2634-33-5   *Thiazoles Preservatives, Pharmaceutical.
Pharma Action Disinfectants ; Platelet Aggregation Inhibitors 		Arch Dermatol. 2006;142:1326-1330; Contact Dermat 2:340;1976
bromochlorophen  15435-29-7 3,3-dibromo-5,5-dichloro-2,2-dihydroxydiphenylmethane  *Chlorophenols Preservatives, Pharmaceutical. Rocz Panstw Zakl Hyg 27(5):495;1976; Rocz Panstw Zakl Hyg 29(5):469;1978
2-methyl-4-isothiazolin-3-one  2682-20-4   *Thiazoles Preservatives, Pharmaceutical.
Pharma Action Anti-Infective Agents ; Disinfectants 		J Agr Food Chem 23(6):1060;1975
5-chloro-2-methyl-4-isothiazolin-3-one  26172-55-4   *Thiazoles Preservatives, Pharmaceutical.
Pharma Action Anti-Infective Agents ; Disinfectants 		J Agric Food Chem 23(6):1060;1975
bronopol  52-51-7 2-bromo-2-nitropropane-1,3-diol  *Propylene Glycols Preservatives, Pharmaceutical.
Pharma Action Anti-Infective Agents ; Anti-Infective Agents, Local ; Indicators and Reagents 		Acta Pharmacol Toxicol 37:237;1975; Contact Dermatitis 3(2):99;1977; Cutis 22(6):655;1978; Food Cosmet Toxicol 14:183;1976; Food Cosmet Toxicol 14:189;1976; Food Cosmet Toxicol 17(2):105;1979; J Appl Bacteriol 45(1):137;1978; J Dairy Sci 61(7):964;1978
imidazolidinyl urea  39236-46-9 N,N''-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea)  Urea/*analogs & derivatives Pharmaceutic Aids Preservatives, Pharmaceutical. Arch Dermatol 110(3):463;1974; Cutis 22(6):655;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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