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Procarbazine

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Definition: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.     
Pharmacological Action Antineoplastic Agents 		Other names Sigma Tau Brand of Procarbazine Hydrochloride; Monohydrochloride, Procarbazine; Monohydrobromide, Procarbazine; Hydrochloride, Procarbazine; Sigma-Tau Brand of Procarbazine Hydrochloride; Sigma-Tau Brand of Procarbazine; Roche Brand of Procarbazine Hydrochloride; Procarbazine Monohydrochloride; Procarbazine Monohydrobromide; Procarbazine Hydrochloride; Natulan; Matulane; Cambridge Laboratories Brand of Procarbazine HydroDrugs* : MATULANE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
COPP-ABVD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dacarbazine Doxorubicin Prednisone Procarbazine Vinblastine Vincristine. Pediatr Blood Cancer 2007 Aug;49(2):139-44
MOPPEBVCAD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin/*analogs & derivatives Lomustine Mechlorethamine Melphalan Prednisone Procarbazine Vinblastine Vincristine Vindesine. J Clin Oncol. 2005 Dec 20;23(36):9198-207
ChlVPP-EVA regimen  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisolone Procarbazine Vinblastine Vincristine. J Clin Oncol 2002 Jul 1;20(13):2988-94
VEPEMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Mitoxantrone Procarbazine Vinblastine. Tumori 2002 Jan-Feb;88(1 Suppl 1):S29-31
PMV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Nitrosourea Compounds Procarbazine Vincristine. Neurol Med Chir (Tokyo) 2001 Mar;41(3):115-9; discussion 119-20
TPDCV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Lomustine Mitolactol Procarbazine Thioguanine Vincristine. Neuro-oncol 2000 Jan;2(1):22-8
DFMO-PCV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Eflornithine Lomustine Procarbazine Vincristine. Clin Cancer Res 2000 Oct;6(10):3878-84
BMPD protocol  0   Carmustine Dexamethasone *Antineoplastic Combined Chemotherapy Protocols Leucovorin Methotrexate Procarbazine. Leukemia Lymphoma 1998 Aug;30(5-6):609-17
vvp protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Procarbazine Vincristine. J Neurooncol 1998 Mar;37(1):55-62
THP-COPBLM regimen  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin/analogs & derivatives Prednisone Procarbazine Vincristine Granulocyte Colony-Stimulating Factor. Leukemia 1997 Nov;11(11):1817-20
TPDC-FuHu protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Hydroxyurea Lomustine Mitolactol Procarbazine Thioguanine. J Clin Oncol 1997 Mar;15(3):1063-70
CODBLAM IV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Dexamethasone Doxorubicin Procarbazine Vincristine. Am J Clin Oncol 1997 Feb;20(1):90-6
EPVP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Etoposide Prednisolone Procarbazine Vindesine. Gan To Kagaku Ryoho 1996 Mar;23(4):499-501
AVPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Etoposide Prednisolone Procarbazine. Intern Med 1995 Oct;34(10):123-6
CVPPABO protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Prednisone Procarbazine Vinblastine Vincristine. Blood 1995 Jul 15;86(2):451-6
VECABOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Prednisone Procarbazine Vinblastine Vincristine. Blood 1995 Jul 15;86(2):451-6
MVPP-Bleo protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Mitoxantrone Prednisone Procarbazine Vincristine. Leuk Lymphoma 1994 Sep;15(1-2):153-7
VAPE protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Etoposide Procarbazine Vincristine. Am J Clin Oncol 1994 Dec;17(6):527-37
ML-Y1 protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Methotrexate Prednisolone Procarbazine Vincristine. Nippon Ronen Igakkai Zasshi 1994 Feb;31(2):135-41
NOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mitoxantrone Prednisone Procarbazine Vincristine. Ann Oncol 1994;5 Suppl 2;73-7
Dexa-PAMB protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cytarabine Dexamethasone Mitoxantrone Procarbazine. Dtsch Med Wochenschr 1993 May 28;118(21):780-4
SIOP-II protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Methotrexate Procarbazine Vincristine. Strahlenther Onkol 1993 Apr;169(4):213-21
BEACOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Cyclophosphamide Doxorubicin Etoposide Prednisone Procarbazine Vincristine. Ann Hematol 1993 Mar;66(3):141-6
PAVe protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Procarbazine Vinblastine. Ann Oncol 1992 Nov;3(9):747-54
MVPF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Procarbazine Vinblastine Mitomycin. Am J Clin Oncol 1992 Dec;15(6):480-6
benzylazoxyprocarbazine  66944-55-6   Procarbazine/*analogs & derivatives. J Pharm Pharmacol 1992 Jun;44(6):494-9
BEMP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Etoposide Mitoxantrone Procarbazine. Gan To Kagaku Ryoho 1992 Feb;19(2):241-4
LOPP protocol 2  0   *Antineoplastic Combined Chemotherapy Protocols Lomustine Prednisone Procarbazine Vincristine. Neoplasma 1991;38(6):583
Pro-MACE-C-MOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Leucovorin Cyclophosphamide Doxorubicin Etoposide Methotrexate Prednisone Procarbazine Vincristine. Acta Oncol 1991;30(7):823
N-isopropyl-4-formylbenzamide  13255-50-0   Procarbazine/*analogs & derivatives. Cancer Res 1991;51(16):4170
PCAV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Procarbazine Vinblastine. Eur J Haematol 1991;46(5):306
LOPP protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisolone Procarbazine Vincristine. Br J Cancer 1991;63(4):579
CHLOROPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Procarbazine. Br J Radiol 1991;64(757):55
ProMACE-MOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Mechlorethamine Methotrexate Prednisone Procarbazine Vincristine. J Clin Oncol 1991;9(1):25
CVPP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisolone Procarbazine Vinblastine. Ter Arkh 1990;62(7):72
CMPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Mitoxantrone Prednisolone Procarbazine. Acta Oncol 1990;29(6):733
CEPP protocol  0   Etoposide *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisone Procarbazine Bleomycin. Blood 1990;76(7):1293
BOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cisplatin Procarbazine Vincristine. J Chemother 1990;2(1):67
ECAPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Prednisone Procarbazine. Am J Clin Oncol 1990;13(2):181
OPPA protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Prednisone Procarbazine Vincristine. Cancer 1990;65(6):1298
VIPP-BM protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Etoposide Ifosfamide Methotrexate Prednisolone Procarbazine. Rinsho Ketsueki 1989;30(3):289
BCPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Carmustine Cyclophosphamide Prednisolone Procarbazine. Gan To Kagaku Ryoho 1989;16(6):2269
MCPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Nitrosourea Compounds Prednisolone Procarbazine. Gan To Kagaku Ryoho 1989;16(6):2269
COMP-VAN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Doxorubicin Etoposide Methotrexate Procarbazine Vincristine Nimustine. Gan To Kagaku Ryoho 1989;16(4 Pt 2-2):1341
methylazoxyprocarbazine  66944-56-7   Procarbazine/*analogs & derivatives. Cancer Res 1989;49(9):2442-7
MMPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Nitrosourea Compounds Prednisolone Procarbazine. Gan To Kagaku Ryoho 1989;16(4 Pt 1):863
CEP regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Procarbazine Epirubicin. Tumori 1988;74(5):563
MV26PD protocol  0   *Antineoplastic Combined Chemotherapy Protocols Dexamethasone Methotrexate Procarbazine Teniposide. Med Pedatr Oncol 1988;16(6):375
MOPP-ABV protocol  0   *Antineoplastic Combined Chemotherapy Protocols Bleomycin Doxorubicin Mechlorethamine Prednisone Procarbazine Vinblastine Vincristine. Semin Hematol 1988;25(2 Suppl 2):34
C'MP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Lomustine Methotrexate Procarbazine. Tumori 1988;74(2):207
CE-AVN protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Etoposide Procarbazine Vincristine Nimustine. Gan To Kagaku Ryoho 1988;15(4 Pt 1):643
CMOPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Prednisolone Procarbazine Vincristine. Cancer Chemother Pharmacol 1987;20(1):53
MPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Melphalan Prednisone Procarbazine. Rev Med Chil 1986;114(5):436
FONP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Nitrogen Mustard Compounds Procarbazine Vincristine. Chung Hua Chung Liu Tsa Chih 1986;8(5):381
OEPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Prednisone Procarbazine Vincristine Epirubicin Stereoisomerism. Tumori 1987;73(1):43
CHIVPP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Chlorambucil Prednisone Procarbazine Vinblastine. Ir J Med Sci 1986;155(9):300
LTPP protocol  0   Lomustine *Antineoplastic Combined Chemotherapy Protocols Prednisone Procarbazine Teniposide. Pol Tyg Lek 1986;41(7):199
VPC protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Procarbazine Vinblastine. Wiad Lek 1985;38(4):265
MOP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Mechlorethamine Procarbazine Vincristine. Int Radiat Oncol Biol Phys 1985;11(2):349
COFP protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Cyclophosphamide Fluorouracil Procarbazine Vincristine. Int J Radiat Oncol Biol Phys 1984;10(11):2139
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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