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ψ 

Proline

More information in Books or onNLM PubMed
Definition: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.  /biosyn /defic /physiol permitted   
Examples Captopril; Fosinopril; Hydroxyproline 		Other names L Proline; L-Proline
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
BI 99179  0   *Benzoxazoles Proline/*analogs & derivatives Fatty Acid Synthetase Complex/antagonists & inhibitors. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.
BMS 346  0   *Stilbenes Proline/*analogs & derivatives. Antimicrob Agents Chemother. 2011 Aug;55(8):3795-802.
PRRT2 protein, human  0   *Membrane Proteins *Nerve Tissue Proteins Proline. Nat Genet. 2011 Dec;43(12):1252-5
ethyl tumonoate A  0   Proline/*analogs & derivatives Anti-Inflammatory Agents, Non-Steroidal. J Nat Prod. 2011 Aug 26;74(8):1737-43
GPGPGP peptide  0   *Oligopeptides Glycine/*analogs & derivatives Proline/*analogs & derivatives. Eksp Klin Gastroenterol. 2011;(5):53-5
3-((4-(2-styrylphenoxy)butanoyl)-4-hydroxyprolyl)thiazolidine  0   *Thiazolidines Proline/*analogs & derivatives. Biochem Biophys Res Commun 2011 Jun 17;409(4):693-8
fuligocandin A  0   Proline/*analogs & derivatives. J Org Chem. 2011 Mar 18;76(6):1554-61
beta-(1,4)-L-arabinosyl-(2S,4R)-4-hydroxyproline  0   Proline/*analogs & derivatives. Org Lett. 2010 Nov 5;12(21):4968-71
1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester  0   *Quinolines Proline/*analogs & derivatives Phosphodiesterase 4 Inhibitors. Eur J Pharmacol 2010 Sep 25;643(2-3):274-81
N-tert-butyloxycarbonylpyrrolidine-2-carboxylic acid (2'-(4-trimethoxysilylbenzylamide)cyclohexyl)amide  0   *Organosilicon Compounds Proline/*analogs & derivatives. Chemistry 2010 Jul 12;16(26):7852-8
2 nitroxyethyl ether LN-((2-(nitroxy)ethyl)fullerenyl)proline  0   *Nitro Compounds *Fullerenes Proline/*analogs & derivatives. Biofizika. 2010 May-Jun;55(3):394-9
LN-((2,3-dinitroglyceryl)fullerenyl)proline, methyl ester  0   *Nitro Compounds *Fullerenes Proline/*analogs & derivatives. Biofizika. 2010 May-Jun;55(3):394-9
LN-((2-nitroglyceryl)fullerenyl)proline, methyl ester  0   *Nitro Compounds *Fullerenes Proline/*analogs & derivatives. Biofizika. 2010 May-Jun;55(3):394-9
4-phenylbutanoyl-prolylcyanopyrrolidine  0   Proline/*analogs & derivatives. Basic Clin Pharmacol Toxicol 2010 Apr;106(4):280-7
3,3-dimethyl isopropylidene proline  0   Proline/*analogs & derivatives. J Org Chem. 2010 Feb 19;75(4):1285-8
N-biphenyl-2-yl-1-(((1-methyl-1H-benzimidazol-2-yl)sulfanyl)acetyl)prolinamide  0   *Benzimidazoles Proline/*analogs & derivatives. Bioorg Med Chem Lett 2008 Feb 15;18(4):1425-30
dinitrophenyl-proline-N-hydroxysuccinimide ester  0   *Succinimides Proline/*analogs & derivatives. Biomed Chromatogr 2009 Dec;23(12):1291-9
N-methoxycarbonyl-proline-N'-methylamide  0   Proline/*analogs & derivatives. J Comput Chem 2009 May;30(7):1116-27
1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid  0   *Benzamides Proline/*analogs & derivatives. J Pharmacol Exp Ther 2009 Jun;329(3):1127-33
5-phenyl proline  0   Proline/*analogs & derivatives. Bioorg Med Chem. 2009 Apr 1;17(7):2886-93
4-n-propyl-L-proline  0   Proline/*analogs & derivatives. Anal Bioanal Chem. 2009 Mar;393(6-7):1779-87
(2S,5S)-trans-carboxymethylproline  0   Proline/*analogs & derivatives. Chembiochem 2009 Jan 26;10(2):246-50
pidobenzone  0   Proline/*analogs & derivatives. Dermatol Ther 2008 Jul;21 Suppl 1:S18-9
prolyl-4-hydroxyproline  0   *Dipeptides Proline Biological Markers. Clin Chem Lab Med 2008;46(10):1391-7
5-(ethoxycarbonyl)methylproline  0   Proline/*analogs & derivatives. J Org Chem. 2008 Sep 19;73(18):7420-3
tumonoic acid D  0   Proline/*analogs & derivatives. J Nat Prod 2008 Sep;71(9):1530-7
4-chloroproline  0   Proline/*analogs & derivatives. Biopolymers 2008 May;89(5):443-54
diphenylprolinol silyl ether  0   *Ethers Proline/*analogs & derivatives. Angew Chem Int Ed Engl. 2008;47(21):4012-5
6-N-(2'-pyrrolidinylcarbonyl)amino-6-(2-methylpropyl)-8a-carboxamidoindolizidine-5-one  0   *Indolizidines Proline/*analogs & derivatives. J Med Chem 2007 Dec 27;50(26):6725-9
siloxyproline  0   Proline/*analogs & derivatives. Chem Asian J. 2008 Feb 1;3(2):225-32
5-methyl-3-pyrrolidinecarboxylic acid  0   Proline/*analogs & derivatives. J Am Chem Soc 2008 Jan 23;130(3):875-86
prophalan  0   Melphalan/*analogs & derivatives Proline/*analogs & derivatives. Mol Pharm 2005 Jan-Feb;2(1):37-46
N2-fluorenylmethoxycarbonyl-4-hydroxyproline allyl ester  0   *Fluorenes Proline/*analogs & derivatives. Carbohydr Res 2007 Dec 10;342(17):2628-34
N-(1-deoxy-beta-d-fructopyranos-1-yl)-l-proline  0   *Monosaccharides Proline/*analogs & derivatives. Int Immunopharmacol. 2007 Dec 5;7(12):1577-81
alpha,alpha-diphenylprolinol trimethylsilyl ether  0   *Ethers Proline/*analogs & derivatives. Angew Chem Int Ed Engl. 2007;46(42):8054-6
N-(2-Nitrophenyl)proline  0   *Nitro Compounds Proline/*analogs & derivatives. Org Lett 2007 Sep 13;9(19):3853-5
fuligocandin B  0   Proline/*analogs & derivatives. Blood 2007 Sep 1;110(5):1664-74
Zn-proline  0   *Organometallic Compounds Proline/*analogs & derivatives. Chem Pharm Bull (Tokyo) 2007 Aug;55(8):1254-7
N-(4-nitrophenyl)-4-hydroxyproline  0   Proline/*analogs & derivatives. J Phys Chem B 2007 Jun 28;111(25):7224-33
N-(4-nitrophenyl)proline  0   *Nitrobenzenes Proline/*analogs & derivatives. J Phys Chem B 2007 Jun 28;111(25):7224-33
4,5-methanoproline  0   Proline/*analogs & derivatives. Org Lett 2006 Oct 12;8(21):4787-90
(1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid  0   Proline/*analogs & derivatives. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1651-4
N-retinoylproline  0   Proline/*analogs & derivatives Tretinoin/*analogs & derivatives. Cell Biol Int 2006 Aug;30(8):672-80
N,N',N-bis(methyl-L-prolinate)  0   Proline/*analogs & derivatives. Inorg Chem. 2006 May 15;45(10):4214-27
N'-benzyl-N'-prolyl proline hydrazide  0   *Hydrazines Proline/*analogs & derivatives. Chem Commun (Camb). 2006 Jan 14;(2):206-8
proline N-carboxyanhydride  0   *Anhydrides Proline/*analogs & derivatives. Org Lett 2006 Nov 9;8(23):5385-8
LY52 compound  0   *Caffeic Acids Proline/*analogs & derivatives Matrix Metalloproteinase 2/antagonists & inhibitors. Int J Mol Med 2006 Oct;18(4):609-14
Pro-Pro-Pro-NH2  0   *Oligopeptides Proline. Org Lett 2006 Mar 2;8(5):983-6
4-(beta-naphthalenyl)methoxyproline  0   *Naphthalenes Proline/*analogs & derivatives. Chirality 2005 Feb;17(2):119-20
N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide  0   Proline/*analogs & derivatives. Antiviral Res 2006 Jun;70(2):28-38VICTRELIS
prolyl-4-piperidinylacetic acid  0   *Acetic Acids *Piperidines Proline/*analogs & derivatives. Bioorg Med Chem. 2006 Apr 15;14(8):2725-46
prolyl-1-piperazinylacetic acid  0   *Acetic Acids *Piperazines Proline/*analogs & derivatives. Bioorg Med Chem. 2006 Apr 15;14(8):2725-46
(2S, 3R, 4R)-4-hydroxy-3-methylproline  0   Proline/*analogs & derivatives. Org Biomol Chem. 2005 Aug 7;3(15):2741-9
N-acetylproline-N',N'-dimethylamide  0   Proline/*analogs & derivatives. Biophys Chem 2005 Jan 1;113(1):93-101
3,4-(aminomethano)proline  0   *Methylamines Proline/*analogs & derivatives. Chemistry. 2005 Nov 4;11(22):6593-600
N-methylproline  0   Proline/*analogs & derivatives. Phytochemistry 2006 Jan;67(2):156-60
4-hydroxy-N-methylproline  0   Proline/*analogs & derivatives. Phytochemistry 2006 Jan;67(2):156-60
3-hydroxy-N-methylproline  0   Proline/*analogs & derivatives. Phytochemistry 2006 Jan;67(2):156-60
tetrakis-dirhodium(II)-(S)-N-(n-perfluorooctylsulfonyl)prolinate  0   *Organometallic Compounds Proline/*analogs & derivatives Rhodium. Org Lett 2005 Apr 28;7(9):1841-4
4-phenoxyproline  0   Proline/*analogs & derivatives. Chirality 2005 Nov;17(9):556-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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