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Prostaglandins E, Synthetic

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Definition: Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.  DF: PGE SYN   
Examples Arbaprostil; 16,16-Dimethylprostaglandin E2; Enprostil; Misoprostol; Rioprostil 		Other names Prostaglandin E Analogs; PGE Synthetic; Synthetic, PGE; Analogues, Prostaglandin E; Analogs, Prostaglandin E; Synthetic Prostaglandins E; Prostaglandin E Analogues
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GR 63799X  106342-69-2   *Prostaglandins E, Synthetic. Adv Prostaglandin Thromboxane Leukotriene Res 1991;21A:379
RS 61565  138258-82-9   *Prostaglandins E, Synthetic Intraocular Pressure/drug effects. Invest Ophthalmol Vis Sci 1990;31(12):2560
RS 20216  138230-19-0   *Prostaglandins E, Synthetic Intraocular Pressure/drug effects. Invest Ophthalmol Vis Sci 1990;31(12):2560
Ro 22-1327  69900-71-6   *Prostaglandins E Prostaglandins E, Synthetic. J Cardiovasc Pharmacol 1987;9(3):285
butaprost  69648-38-0 Cyclopentaneheptanoic acid, 3-hydroxy-2-(4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl)-5-oxo-, methyl ester, (1R-(1alpha,2beta(1E,4R*),3alpha))  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Br J Pharmacol 1986;87(1):45
NP 13 A  98677-34-0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Gan To Kagaku Ryoho 1985;12(8):1669
NP 07 A  98677-36-2   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Gan To Kagaku Ryoho 1985;12(8):1669
NP 01A  98677-35-1 Prost-13-en-1-oic acid, 15-hydroxy-10,10-dimethyl-6,9-dioxo-, (13E,15S)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Gan To Kagaku Ryoho 1985;12(8):1669
Wy 17186  55820-86-5   *Prostaglandins E, Synthetic Muscle Contraction/drug effects. Prostaglandins 1985;29(3):363
ornoprostil  85679-51-2   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Adv Exp Med Biol 1984;180:763
Ro 22-6923  81397-66-2   *Prostaglandins E, Synthetic. J Pharmacol Exp Ther 1985;232(1):202
16-hydroxy-16-methyl-9-oxo-prosta-10,13-dien-1-oic acid methyl ester  58682-86-3 Prosta-10,13-dien-1-oic acid, 16-hydroxy-16-methyl-9-oxo-, methyl ester, (13E)-(+-)  *Prostaglandins E, Synthetic. J Pharm Sci 1984;73(3):306
prostaglandin E1-hexyl-sepharose  0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Eur J Biochem 1983;136(1):57
16,16-dimethyl-delta2-prostaglandin E1  64318-77-0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 1983;25(2):225
MDL 646  83656-28-4 Prost-13-en-1-oic acid, 11,15-dihydroxy-16-methoxy-16-methyl-9-oxo-, (11alpha,13E,15R,16R)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Acta Biomed Ateneo Parmense 1982;53(3):117
11-deoxyprostaglandin E1  37786-00-8   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic.
Pharma Action Anti-Ulcer Agents 		Probl Endokrinol (Mosk) 1982;28(2):63
CL 115574  74159-84-5 Prost-13-ene-1,9-dione, 11,16-dihydroxy-1-(hydroxymethyl)-16-methyl-, (11alpha,13E)-(+-)  *Prostaglandins E, Synthetic. Prostaglandins 1981;22(6):957
11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1  80558-61-8 Cyclopentaneheptanoic acid, 2-(3-hydroxy-4-phenoxy-1-butenyl)-5-oxo-, (1R-(1alpha,2beta(1E,3R*)))  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic Receptors, Prostaglandin E/agonists.
Pharma Action Anti-Ulcer Agents 		Prostaglandins 1981;22(2):167
7-oxo-15-methylprostaglandin E1 methyl ester  68538-80-7   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Yakugaku Zasshi 1981;101(3):247
CL 116069  79378-27-1 Cyclopentanone, 4-hydroxy-2-(8-hydroxy-7-oxo-2-octenyl)-3-(3-hydroxy-4-phenoxy-1-butenyl)-, (2alpha(Z),3beta(1E,3R*),4alpha)-(+-)  *Prostaglandins E, Synthetic. Prostaglandins 1981;21(6):1015
CP 48630  77107-52-9   *Prostaglandins E, Synthetic. Prostaglandins 1981;21(2):259
8-azaprostaglandin E1  0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Boll Soc Ital Biol Sper 1980;56(11):1137
TR4161  21562-57-2 prost-13-en-9-one, 1,11,15-trihydroxy-, (9alpha,13E,15S)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 1980;19(3):349
ONO 1206  74397-12-9 Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11alpha,13E,15S,17S)  Alprostadil/*analogs & derivatives Platelet Aggregation/drug effects Prostaglandins E, Synthetic.
Pharma Action Vasodilator Agents 		Adv Prostaglandin Thromboxane Res 1980;6:347
3-oxa-4,5,6-nor-(3,7-inter)-3-phenyleneprostaglandin E1 methyl ester  0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Steroids 1980;19(1):123
3-oxa-4,5,6-nor-3,7-inter-3-phenyleneprostaglandin E1  0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Steroids 1980;19(1):123
11,15-bisdeoxyprostaglandin E1  40098-50-8 Prost-13-en-1-oic acid, 9-oxo-, (13E)-(+-)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 1980;19(2):213
3-oxa-4,5,6-trinor-3,7-inter-3-phenyleneprostaglandin E1 amide  0   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 1980;19(1):123
1a,1b-dihomoprostaglandin E2  26198-80-1 (1R-(1 alpha(Z),2 beta(1E,3S*),3 alpha))-9-(3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl)-7- nonenoic acid  Dinoprostone/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 10(3):443;1975; Prostaglandins 18(4):617;1979
11-deoxy-16,16-trimethyleneprostaglandin E1  62407-92-5 Cyclopentaneheptanoic acid, 2-(3-(1-butylcyclobutyl)-3-hydroxy-1-propenyl)-5-oxo-, (1alpha,2beta(1E,3S*))-(+-)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 18(3):349;1979
11-deoxy-10-hydroxyprostaglandin E1 methyl ester  64318-57-6 Prost-13-en-1-oic acid, 10,15-dihydroxy-9-oxo-, methyl ester, (10alpha,13E,15S)-(+-)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. Prostaglandins 18(4):569;1979
gemeprost  64318-79-2 (2E,11 alpha,13E,15R)-11,15-dihydroxy-16,16- dimethyl-9-oxoprosta-2,13-dien-1-oic acid, methyl ester  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic.
Pharma Action Abortifacient Agents, Nonsteroidal 		Contraception 19(6):591;1979
16,16-dimethylprostaglandin E  41692-15-3   *Prostaglandins E, Synthetic. Exp Neurol 60(1):56;1978
11-deoxy-8-azaprostaglandin E(1)  57740-61-1   Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. J Org Chem 42(19):3201;1977
11-deoxy-13,14-dihydro-8-azaprostaglandin E(1)  62006-01-3 1-Pyrrolidineheptanoic acid, 2-oxo-5-(3-oxooctyl)  Alprostadil/*analogs & derivatives Prostaglandins E, Synthetic. J Org Chem 42(12):2103;1977
ONO-747  54443-06-0 (2E,11 alpha,13E,15S)-17-ethyl-11,15-dihydroxy-9-oxoprosta-2,13-dien-1-oic acid  *Prostaglandins E, Synthetic. Adv Prostaglandins Thromboxanes Res 2 W1 AD787:781;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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