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Prostaglandins, Synthetic

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Definition: Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity.  GEN or unspecified only: prefer specifics; for synthetic prostaglandins not precoord, coord specific non-synthetic (natural) prostaglandin term (NIM) + PROSTAGLANDINS, SYNTHETIC (IM); DF: PG SYN   
Examples Iloprost; Prostaglandin Endoperoxides, Synthetic; Prostaglandins A, Synthetic; Prostaglandins E, Synthetic; Prostaglandins F, Synthetic 		Other names Prostaglandin Analogs; PG Analogs; Analogues, Prostaglandin; Analogs, Prostaglandin; Analogs, PG; Synthetic Prostaglandins; Prostaglandin Analogues
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AL-12182  0   *Prostaglandins, Synthetic. J Org Chem. 2005 Feb 18;70(4):1227-36
GIF 0037  0   *Prostaglandins, Synthetic. Biochem J 1998 Oct 1;335( Pt 1):35-42
GIF 0010  0   *Prostaglandins, Synthetic. Biochem J 1998 Oct 1;335( Pt 1):35-42
9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor-5,13-prostadienoic acid  0   *Prostaglandins D Prostaglandins, Synthetic Thromboxane A2/agonists. Prostaglandins 1995 Aug;50(2):57
(+)(-)-8,12-trans-9-oxo-prosta-5,14-dienoic acid  142666-04-4   *Prostaglandins, Synthetic. Farmaco 1992 Mar;47(3):379-85
16,16-dimethylprostaglandin A2 methyl ester  61956-81-8   *Prostaglandins A Prostaglandins, Synthetic. Br J Cancer 1990;61(3):394
ZK 110841  105595-17-3 5-Heptenoic acid, 7-(5-chloro-2-(3-cyclohexyl-3-hydroxy-1-propenyl)-3-hydroxycyclopentyl)-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5beta))  Dinoprost/*analogs & derivatives Prostaglandins, Synthetic. Prog Clin Biol Res 1989;301:597
15-fluoro-13,14-dehydrocarbacyclin  120593-19-3   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Bioorg Khim 1988;14(6):834
17,20-dimethylisocarbacyclin  122168-74-5   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Transplantation 1988;46(4):626
CG 4303  109010-68-6   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Biol Chem Hoppe Seyler 1988;369(5):329
U 62840  81846-19-7 Acetic acid, ((2,3,3a,4,9,9a-hexahydro-2-hydroxy-1-(3-hydroxyoctyl)-1H-benz(f)inden-5-yl)oxy)-, (1R-(1alpha(S*),2beta,3aalpha,9aalpha))  *Prostaglandins, Synthetic. J Chromatogr 1987;408:275
TEI 9090  88931-51-5 2-Pentalenepentanoic acid, 1,3a,4,5,6,6a-hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-, methyl ester, (3aS-(3aalpha,5beta,6alpha(1E,3R*),6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins 1987;33(2):161
5-methyleneisocarbacyclin  109838-17-7   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Chem Pharm Bull (Tokyo) 1986;34(10):4403
OP 41483-alpha-cyclodextrin  108866-14-4   *alpha-Cyclodextrins Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Transplant Proc 1987;19(1 Pt 3):2115
9-chloro-15-cyclohexyl-11,15-dihydroxypentanor-5,13-prostadienoic acid  117708-11-9   *Prostaglandins D *Prostaglandins, Synthetic. Acta Neurochir (Wien) 1986;83(1-2):56
9-fluoro-15-cyclohexyl-11,15-dihydroxypentanor-5,13-prostadienoic acid  117708-12-0   *Prostaglandins D *Prostaglandins, Synthetic. Acta Neurochir (Wien) 1986;83(1-2):56
naxaprostene  89955-40-8   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Arzneimittelforschung 1986;36(8):1180
RS 93427-007  105284-21-7   *Bridged Compounds Epoprostenol Prostaglandins, Synthetic. Lancet 1986;2(8508):682
11-methoxime prostaglandin D2  130377-58-1   *Prostaglandins, Synthetic Prostaglandin D2/*analogs & derivatives. Prostaglandins 1986;31(1):123
6a-carbaprostaglandin I3  96244-85-8   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Chem Pharm Bull (Tokyo) 1984;32(12):4746
EP 092  96384-09-7 5-Heptenoic acid, 7-(3-(1-(((phenylamino)thioxomethyl)hydrazono)ethyl)bicyclo(2.2.1)hept-2-yl)-, (1alpha,2beta(Z),3alpha,4alpha)-(+-)  *Prostaglandins, Synthetic. Br J Pharmacol 1985;84(3):595
ciprostene  81845-44-5 Pentanoic acid, 5-(hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-3a-methyl-2(1H)-pentalenylidene)-, (3aS-(2Z,3aalpha,5beta,6alpha(1E,3R*),6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. J Chromatogr 1985;321(1):209
20-methyl-13,14-didehydro-2,4-inter-3-phenylene prostaglandin I2  96744-62-6   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Exp Mol Pathol 1985:42(2):163
APS 306  90880-59-4   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Trans Am Soc Artif Intern Organs 1984;30:44
cicaprost  95722-07-9   Epoprostenol/*analogs & derivatives Blood Platelets/drug effects Prostaglandins, Synthetic.
Pharma Action Antineoplastic Agents 		Biomed Biochim Acta 1984;43(8-9):S175
9-O-methanoprostaglandin I  99946-24-4   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic.
Pharma Action Fibrinolytic Agents ; Platelet Aggregation Inhibitors 		Chem Pharm Bull (Tokyo) 1984;32(2):424
13,14-didehydro-20-methylcarboprostacyclin  78542-68-4   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins Leukotrienes Med 1983;11(4):391
FCE 21258  71934-91-3   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins Leukotrienes Med 1983;11(4):391
taprostene  87440-45-7 Benzoic acid, 3-((4-(3-cyclohexyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2H-cyclopenta(b)furan-2-ylidene)methyl)-, monosodium salt, (3aR-(2Z,3aalpha,4alpha(1E,3S*),5beta,6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic.
Pharma Action Cardiovascular Agents 		Prostaglandins Leukotrienes Med 1983;11(4):361
R 59274  71806-48-9   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Nippon Kyobu Shikkan Gakki Zasshi 1983;21(4):334
nileprost  71097-83-1   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins Leukotrienes Med 1983;11(3):241
HOE 892  75111-35-2 Butanoic acid, 4-((3,3a,4,5,6,6a-hexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)cyclopenta(b)pyrrol-2-yl)thio)-, methyl ester, (3aR-(3aalpha,4alpha(1E,3S*),5beta,6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins Leukotrienes Med 1983;10(3):231
9-deoxy-delta-9-prostaglandin D2  60203-57-8 Prosta-5,9,13-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,13E,15S)  Prostaglandin D2/*analogs & derivatives Prostaglandins, Synthetic.
Pharma Action Antineoplastic Agents 		Biochem Biophys Res Commun 1982;109(3):626
9-hydroxy-19,20-bisnorprostanoic acid  82598-17-2 Cyclopentaneheptanoic acid, 2-hexyl-5-hydroxy  *Prostanoic Acids Prostaglandins, Synthetic.
Pharma Action Anti-Ulcer Agents ; Expectorants 		Arzneimittelforsch 1982;32(6):657; Ther Ggw 1980;119(5):520
15-ketoprostaglandin B1  57400-40-5   *Prostaglandins B Prostaglandins, Synthetic. Physiol Chem Phys 1982;13(6):531
EMD 33290  82468-60-8 Cyclopentaneheptanoic acid, 3-hydroxy-2-((2-hydroxy-2-methylheptyl)thio)-5-oxo-, 4-(benzoylamino)phenyl ester, (1S-(1alpha,2beta(R*),3alpha))  *Prostaglandins, Synthetic Gastric Mucosa/drug effects. Schweiz Med Wochenschr 1982;112(23):829
EP 045  82597-51-1 5-Heptenoic acid, 7-(3-((((phenylamino)carbonyl)hydrazono)methyl)bicyclo(2.2.1)hept-2-yl)-, (1S-(1alpha,2beta(Z),3alpha,4alpha))  *Prostaglandins, Synthetic. Br J Pharmacol 1982;76(1):149
prostaglandin I2 15-methyl ether  79743-29-6 Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11-hydroxy-15-methoxy-, (5Z,9alpha,11alpha,13E,15S)  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins Med 1981;6(4):345
prostaglandin I2 11-methyl ether  79743-30-9 Prosta-5,13-dien-1-oic acid, 6,9-epoxy-15-hydroxy-11-methoxy-, (5Z,9alpha,11alpha,13E,15S)  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Prostaglandins Med 1981;6(4):345
prostaglandin D3  71902-47-1   *Prostaglandins D Prostaglandins, Synthetic. Eur J Pharmacol 1980;67(1):155
carboprostacyclin  69552-46-1 Pentanoic acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-2(1H)-pentalenylidene)-, (3aS-(2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic.
Pharma Action Platelet Aggregation Inhibitors 		Prostaglandins 1980;19(4):605; Prostaglandins Med 1980;5(2):131
9 alpha,11 alpha,15 alpha-trihydroxy-16-phenoxy-17,18,19,20-tetranorprosta-4,5,13-trienoic acid  61456-25-5 4,5-Heptadienoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)  *Prostaglandins, Synthetic. Biol Reprod 1980;22(3):438; Prostaglandins Med 1980;5(2):93
nitriloprostaglandin I2  67496-60-0 cyclopenta(b)pyrrole-2-pentanoic acid, 3,3a,4,5,6,6a-hexahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-, (3aR-(3a alpha,4 alpha(1E,3S*),5 beta,6a alpha))  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Adv Prostaglandin Thromboxane Res 1980;8:1717; Prostaglandins 1980;19(1):2
10,10-difluoro-13-dehydroprostacyclin  80226-91-1 Prost-5-en-13-yn-1-oic acid, 6,9-epoxy-10,10-difluoro-11,15-dihydroxy-, (5Z,9alpha,11alpha,15S)  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. J Med Chem 1980;23(3):234
prostaglandin Bx  39306-29-1 Prostaglandin Bx  *Polymers *Prostaglandins B Prostaglandins, Synthetic.
Pharma Action Phosphodiesterase Inhibitors 		Adv Prostaglandin Thromboxane Res 1980;7:671; Physiol Chem Phys 1981;13(3):241
5,6-dihydroprostacyclin  62770-50-7 (6S,9 alpha,11 alpha,13E,15S)-6,9- epoxy-11,15-dihydroxyprost-13-en-1-oic acid  Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. Gastroenterology 77(6):1301;1979; Prostaglandins Med 1980;2(3):177
9,11-etheno-16-(4-fluorophenoxyprostaglandin) H2  0   *Prostaglandin H2 Prostaglandins, Synthetic. Brit J Pharmacol 63(2):362P;1978
6,9-thiaprostacyclin  64868-63-9   Epoprostenol/*analogs & derivatives Prostaglandins, Synthetic. J Am Chem Soc 99(23):7736;1977
azo analog I  64192-56-9 9,11-azoprosta-5,13-dienoic acid  *Prostaglandins H Prostaglandins, Synthetic. Biochem Biophys Res Commun 79(1):305;1977; Biochim Biophys Acta 539:162;1978; Proc Natl Acad Sci USA 74(9):4007;1977; Prostaglandins 14(5):897;1977
azo analog II  67901-99-9 (5Z,9 alpha,11 alpha,13E,15S)-9,11-azo-15-hydroxyprosta-5,13-dienoic acid  *Prostaglandins H Prostaglandins, Synthetic. Life Sci 18:169;1976; Nature 273(5660):302;1978; Proc Natl Acad Sci USA 72(9):3355;1975; Proc Soc Exp Biol Med 153(2):209;1976

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