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Protamines

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Definition: A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)  heparin antag   
Pharmacological Action Heparin Antagonists
Examples Clupeine; Salmine 		Other names Protamine Sulfate; Sulfate, Protamine; Chloride, Protamine; Protamine ChlorideDrugs* : PROTAMINE SULFATE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Prm1 protein, mouse  0   *Protamines.
Prm1 protein, rat  0   *Protamines.
Mst35Ba protein, Drosophila  0   *Protamines *Drosophila Proteins. Mol Cell Biol 2005 Jul;25(14):6165-77
Mst35Bb protein, Drosophila  0   *Protamines *Drosophila Proteins. Mol Cell Biol 2005 Jul;25(14):6165-77
neutral protamine lispro  0   *Protamines Insulin/*analogs & derivatives. Diabetes Care 1997 Dec;20(12):1870-3HUMALOG MIX 50/50 PEN; HUMALOG MIX 75/25; HUMALOG MIX 75/25 KWIKPEN; HUMALOG MIX 75/25 PEN; HUMALOG MIX 50/50 KWIKPEN; HUMALOG MIX 50/50
protamine +18RGD  0   *Protamines. J Vasc Surg 1997 Dec;26(6):1043-8
protamine R3  0   *Protamines. J Mol Evol 1996 Nov;43(5):528-35
protamine 1, lizard sperm  0   *Protamines *Reptilian Proteins. C R Acad Sci III 1996 Jun;319(6):511-6
protamine-like protein III  0   *Protamines. FEBS Lett 1995 Apr 17;363(1-2):37-40
protamine-heparin membrane  0   *Heparin *Polyethyleneimine *Protamines Membranes, Artificial. Transplant Proc 1994 Apr;26(2):807-8
scombrine  0   *Protamines. J Biochem (Tokyo) 1993 June;113(6):658-64
PRM1 protein, human  0   *Protamines. Anim Genet 1993 Apr;24(2):142
sagaxine 2  0   *Protamines. Arch Biol Med Exp (Santiago) 1991;24(1):67-74
sagaxine 1  0   *Protamines. Arch Biol Med Exp (Santiago) 1991;24(1):67-74
protamine Z3  0   *Protamines. Biochim Biophys Acta 1993 Mar 5;1162(1-2):99-104
sardaine Z2  140877-82-3 Thynnin Y 2 (tunny), 6-L-arginine  *Protamines. J Biochem (Tokyo) 1992 Feb;111(2):157-61
sardaine Z1  50924-08-8   *Protamines. J Biochem (Tokyo) 1992 Feb;111(2):157-61
protamine P4  137368-49-1   *Protamines Spermatozoa. Eur J Biochem 1991;200(2):387
protamine P2 precursor  0   *Protamines *Protein Precursors. Biochem J 1991;277(Pt 1):39
protamine 2  0   *Protamines. Proc Natl Acad Sci USA 1991;88(9):3584
protamine zinc  0   *Protamines Zinc. Arch Dermatol 1990;126(8):1029
mugiline beta  53240-94-1   *Protamines. J Biochem (Tokyo) 1987;101(4):1017
protamine Z1  0   *Protamines. Eur J Biochem 1987;165(3):553
protamine St1  0   *Protamines. Biochim Biophys Acta 1987;913(2):145
protamine P3  0   *Protamines. Biotechnol Appl Biochem 1987;9(1):82
protamine Z2  105005-94-5   *Protamines. Eur J Biochem 1986;160(2):305
protamine-ferritin conjugate  0   *Ferritins *Protamines. Acta Histochem (Jena) 1985;77(1):117
protamine P2  0   *Protamines. Eur J Biochem 1986;156(1):5
glucagon, protamine zinc  37328-83-9 Glucagon protamine zinc  *Glucagon *Protamines Drug Combinations. J Pediatr 1986;108(1):97
protamine P1  0   *Protamines. Biosci Rep 1985;5(5):383
thynnine  0   *Protamines. Bioploymers 1984;23(11 pt 2):2559
protamine heparin aggregate  0   *Heparin *Protamines. Lab Invest 1981;44(6):502
somatostatin, protamine zinc  0   *Protamines *Somatostatin Drug Combinations. Can J Physiol Pharmacol 1980;58(8):951
protamine B, Acipenser gueldenstaedtii  58739-75-6   *Protamines *Fish Proteins. Biokhimiia 42(9):1668;1977
protamine A, Acipenser stellatus  69680-76-8   *Protamines *Fish Proteins. Biokhimiia 1980;45(4):733; Biokhimiia 42(9):1668;1977
Stellin  59041-50-8 Stellin  *Protamines. Biokhimiia 1980;45(4):733
ekmolin  8001-16-9   *Protamines Fishes Tissue Extracts. Vestn Dermatol Venerol 7:46;1978
deoxyribonucleoprotamine  0   *Protamines. Indian J Biochem Biophys 14(1):21;1977
sturin  59141-16-1 Sturin  *Protamines. Biokhimiia 42(9):1668;1977
galline  52012-17-6 Galline  *Protamines. Int J Peptide Protein Res 7(1):31;1975
iridine  67255-34-9 Iridine  *Protamines. Int J Pept Protein Res 1(3):221;1969

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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