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Protease Inhibitors

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Definition: Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).  PROTEASE INHIBITORY PROTEINS, SECRETORY is also available; DF: PROTEASE INHIB   
See Also Proteinase Inhibitory Proteins, Secretory
Examples Angiotensin-Converting Enzyme Inhibitors; Cysteine Proteinase Inhibitors; Dipeptidyl-Peptidase IV Inhibitors; HIV Protease Inhibitors; Serine Proteinase Inhibitors 		Other names Protease Antagonists; Peptide Peptidohydrolase Inhibitors; Peptide Hydrolase Inhibitors; Peptidase Inhibitors; Endopeptidase Inhibitors; Peptidohydrolase Inhibitors, Peptide; Inhibitors, Protease; Inhibitors, Peptide Peptidohydrolase; Inhibitors, Peptide Hydrolase; Inhibitors, Peptidase; Inhibitors, Endopeptidase; Inhibitor, Protease; Hydrolase Inhibitors, Peptide; Antagonists, Protease; Protease Inhibitor; Antiproteases
Substances having this pharmacologic action: globomycin; alpha 1-inhibitor 3; proteinase inhibitor I (plants); 1,10-phenanthroline; 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate; renin inhibitory peptide; 2-mercaptomethyl-3-guanidinoethylthiopropionic acid; 4-hydroxymercuribenzoate; pepstatin; nafamostat; FOY 305; 1,6-bis(cyclohexyloximinocarbonyl)hexane; ovomacroglobulin; NCO 650; 1,2-epoxy-3-(p-nitrophenoxy)propane; phosphoramidon; Proteinase Inhibitory Proteins, Secretory; Elafin; omapatrilat; 4-toluenesulfonyl fluoride; N-acetyltryptophan; Phenylmethylsulfonyl Fluoride; Antipain; Leupeptins; Thiorphan; Cilastatin; Pepstatins; Isoflurophate; bestatin; 4-aminomethylbenzoic acid; alpha-1-microglobulin; amastatin; sampatrilat; TIMP1 protein, human; TIMP2 protein, human; Timp1 protein, mouse; benzyloxycarbonyl-Asp-CH2OC(O)-2,6-dichlorobenzene; BB 1101; tissue inhibitor of metalloproteinase-4; GM 6001; pigment epithelium-derived factor; batimastat; TIMP3 protein, human; carbobenzoxy-leucyl-leucyl-norvalinal; Sch 39370; candoxatrilat; ecabet; SCH 32615; epicatechin gallate; candoxatril; remikiren; 3-amino-2-hydroxy-4-phenylbutanoic acid; antistasin; 4-des-dimethylaminotetracycline; Sch 34826; enalkiren; sepimostate mesilate; acetorphan; ditekiren; murinoglobulin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NSC48300  0   *Arsenicals Protease Inhibitors. Cancer Res. 2012 Feb 1;72(3):736-46
3,5-bis((4-nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one  0   *Piperidones Protease Inhibitors. Nat Med. 2011 Dec;17(12):636-40
AG1801  0   *Tyrphostins Protease Inhibitors. Cell Signal. 2011 Dec;23(12):2076-85
AGL2019  0   *Tyrphostins Protease Inhibitors. Cell Signal. 2011 Dec;23(12):2076-85
kexstatin I, Streptomyces platensis  0   *Bacterial Proteins Protease Inhibitors. Biochem J 2001 Apr 15;355(Pt 2):339-46
SL 327  0   Aminoacetonitrile/*analogs & derivatives Protease Inhibitors. Blood 2001 Apr 1;97(7):2105-14
1-aminocyclopropaneboronic acid  0   *Boronic Acids *Cyclopropanes Protease Inhibitors. Org Lett 2000 Oct 5;2(20):3095-7
PGE 1132881  0   *Hydroxamic Acids Protease Inhibitors Matrix Metalloproteinases/antagonists & inhibitors. J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
PGE 4410186  0   *Hydroxamic Acids Protease Inhibitors. J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
PGE 9818266  0   *Hydroxamic Acids Protease Inhibitors. J Pharm Biomed Anal 1999 Mar;19(3-4):343-9
BB 1268  0   Organic Chemicals Metalloendopeptidases/antagonists & inhibitors Protease Inhibitors. Ann Neurol 1998 Jul;44(1):35-46
bdellin  62494-89-7   *Organic Chemicals Protease Inhibitors. Res Commun Mol Pathol Pharmacol 1997 Jun;96(3):341-52
CGS 24426A  0   *Succinates Metalloendopeptidases/antagonists & inhibitors Protease Inhibitors. Inflamm Res 1995 Aug;44 Suppl 2:S141-2
CGS 27023A  0   *Hydroxamic Acids *Pyrazines Sulfonamides Metalloendopeptidases/antagonists & inhibitors Protease Inhibitors. Inflamm Res 1995 Aug;44 Suppl 2:S117-8
UK 77568  0   Organic Chemicals Protease Inhibitors Neprilysin/antagonists & inhibitors. Clin Exp Pharmacol Physiol 1994 Apr;21(4):307-9
Cst6 protein, rat  0   *Cystatin M Protease Inhibitors. Gene 1992 May 15;114(2):257-60
gamma-anticollagenase  0   Blood Proteins Protease Inhibitors. Folia Histochem Cytobiol 1986;24(2):125
epigallocatechin gallate  989-51-5   Catechin/*analogs & derivatives Protease Inhibitors Radiation-Protective Agents Urokinase-Type Plasminogen Activator/antagonists & inhibitors.
Pharma Action Antioxidants ; Antimutagenic Agents ; Anticarcinogenic Agents ; Neuroprotective Agents 		Mutat Res 1985;150(1-2):127
antiprotease C-II  0   *Plant Proteins Protease Inhibitors. Biochim Biophys Acta 1981;662(1):1
CSTA protein, human  80209-89-8 Sericystatin  *Cystatin A Protease Inhibitors. Biochem Biophys Res Commun 1980;95(2):801
whey acidic proteins  0   *Milk Proteins Protease Inhibitors. Nucleic Acids Res 1982;10(8):2677
beta (1)-anticollagenase  0   *Blood Proteins Protease Inhibitors. Arthritis Rheumat 20(6):1231;1977
trielin  57274-66-5   Propane/*analogs & derivatives Protease Inhibitors. Klin Khir 1:12;1979; Klin Khir 12:1;1977; Patol Fiziol Eksp Ter 6:58;1976; Ukr Biokhim Zh 47(2):165;1975; Vestn Khir 120(1):13;1978
carboxypolymethylene  9007-20-9   *Polyvinyls Drug Carriers Protease Inhibitors. J Pharm Pharmacol 25(8):640;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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