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Protein Kinase C

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Definition: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.     
Examples Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon 		Other names PKC Serine-Threonine Kinase; Calcium-Activated Phospholipid-Dependent Kinase; Calcium Phospholipid-Dependent Protein Kinase; Serine-Threonine Kinase, PKC; Phospholipid-Dependent Kinase, Calcium-Activated; Phospholipid Sensitive Calcium Dependent Protein K; PKC Serine Threonine Kinase; Calcium Phospholipid Dependent Protein Kinase; Calcium Activated Phospholipid Dependent Kinase; Protein Kinase M; Phospholipid-Sensitive Calcium-Dependent Protein K
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate  0   *Imidazoles *Phosphoric Acid Esters Protein Kinase C/antagonists & inhibitors. Int J Biochem Cell Biol 2011 May;43(5):784-94
PKCz1257.3 compound  0   *Benzylamines *Pyrroles Protein Kinase C/antagonists & inhibitors. Invest New Drugs 2010 Jun;28(3):268-75
protein kinase C zeta, mouse  EC 2.7.11.13   *Protein Kinase C Nerve Tissue Proteins. Biosci Biotechnol Biochem 2009 Jan;73(1):147-51
Par-6 protein, Drosophila  EC 2.7.11.13   *Protein Kinase C *Drosophila Proteins. Cell 2008 Oct 3;135(1):161-73
1-hexylindolactam-V10  0   *Indoles *Lactams Protein Kinase C. J Med Chem 2008 Jan 10;51(1):46-56
DKF-2 protein, C elegans  EC 2.7.10.-   *Protein Kinase C *Caenorhabditis elegans Proteins. J Biol Chem 2007 Oct 26;282(43):31273-88
Pck1 protein, S pombe  EC 2.7.1.37   *Protein Kinase C *Schizosaccharomyces pombe Proteins. Mol Cell Biol 1993 May;13(5):3076-83
protein kinase M zeta, rat  EC 2.7.1.37   *Protein Kinase C. J Neurosci 2005 Feb 23;25(8):1979-84
manzamenone A  0   *Formates *Indans DNA Nucleotidylexotransferase/antagonists & inhibitors DNA Polymerase I/antagonists & inhibitors Protein Kinase C/antagonists & inhibitors DNA Polymerase beta/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Apr 19;14(8):1975-7
PKC1 protein, S cerevisiae  EC 2.7.1.37   *Protein Kinase C *Saccharomyces cerevisiae Proteins. FASEB J 2004 May;18(7):899-901
Prkcq protein, mouse  EC 2.7.1.-   *Isoenzymes *Protein Kinase C Zinc Fingers.
Pkcq protein, rat  EC 2.7.1.-   *Isoenzymes *Protein Kinase C Zinc Fingers.
protein kinase C-binding protein Beta15, rat  0   *Nerve Tissue Proteins Protein Kinase C.
Hint1 protein, mouse  0   *Nerve Tissue Proteins Protein Kinase C.
protein kinase C zeta II, mouse  EC 2.7.1.-   *Protein Kinase C. EMBO J 2004 Jan 14;23(1):77-88
aprinocarsen  0   *Phosphorothioate Oligonucleotides Protein Kinase C/antagonists & inhibitors. Oncol Rep 2004 Feb;11(2):515-22
Go 6983  0   *Carbazoles Protein Kinase C/antagonists & inhibitors. J Biol Chem 2004 Jun 4;279(23):24255-64
nPKC p105, mussel  EC 2.7.1.-   *Protein Kinase C. Mol Cell Biochem 2003 Aug;250(1-2):41-5
goedecke 6976  0   *Carbazoles Protein Kinase C/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Jul;302(1):352-8
daphnetoxin  28164-88-7   *Heterocyclic Compounds with 4 or More Rings Protein Kinase C/agonists. Planta Med 2001 Dec;67(9):787-90
epsilonV1-2 peptide  0   *Peptide Fragments *Protein Kinase C. Cell Signal 2002 Jan;14(1):37-43
NPC 15342  0   *Amides Protein Kinase C/antagonists & inhibitors. J Immunol 2001 Oct 15;167(8):4303-10
5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate  0   *Mesylates *Pyrroles Protein Kinase C/antagonists & inhibitors. Exp Cell Res 2001 Aug 15;268(2):179-88
isoaaptamine  0   *Naphthyridines Protein Kinase C/antagonists & inhibitors. J Org Chem 2000 Nov 17;65(23):8001-10
PKC412  0   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Anticancer Drug Des 2000 Feb;15(1):17-28
compound 371196  0   *Indoles *Maleimides Protein Kinase C/antagonists & inhibitors. Biochem J 2000 Apr 1;347 Pt 1:285-9
CGP 53506  0   *Pyrimidines Protein Kinase C/antagonists & inhibitors. Anticancer Res 1999 Sep-Oct;19(5B):3969-76
AM 44  0   Carnitine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Eur J Biochem 1999 Dec;266(3):855-64
POC 16  0   Carnitine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Eur J Biochem 1999 Dec;266(3):855-64
Apl II protein kinase C  EC 2.7.1.-   *Isoenzymes *Protein Kinase C. Learn Mem 1997 Jan-Feb;3(5):389-401
10''-deoxybalanol  0   *Azepines *Benzophenones Protein Kinase C Cyclic AMP-Dependent Protein Kinases. Mol Pharmacol 1999 Aug;56(2):377-82
protein kinase C nu  EC 2.7.1.-   *Protein Kinase C. Biochim Biophys Acta 1999 May 6;1450(1):99-106
Ro 32-2241  0   *Indoles *Maleimides Protein Kinase C/antagonists & inhibitors. Cancer Chemother Pharmacol 1999;43(5):371-8
1,7-bis(3,4-dihydroxyphenyl)heptan-3-ol  0   *Diarylheptanoids Pinus Protein Kinase C/antagonists & inhibitors.
bisindolylmaleimide II  0   *Indoles *Maleimides Protein Kinase C/antagonists & inhibitors. Mol Pharmacol 1998 Jan;53(1):105-11
calcium-independent protein kinase C  EC 2.7.1.-   *Protein Kinase C Apoptosis. J Biol Chem 1998 Oct 23;273(43):28392-8
phorbol 12-pyrenebutyrate 13-(3,3,3-trifloro-2-diazopropioate)  0   *Diazonium Compounds *Phorbols Isoenzymes Protein Kinase C. Bioorg Med Chem 1998 Jul;6(7):1117-26
PKC-3 protein  EC 2.7.1.-   *Protein Kinase C. Development 1998 Sep;125(18):3607-14
corosolic acid  4547-24-4   *Triterpenes Plant Extracts Protein Kinase C/antagonists & inhibitors. Planta Med 1998 Jun;64(5):468-70
SCH 47112  0   Staurosporine/*analogs & derivatives Protein Kinase C/antagonists & inhibitors. Arch Dermatol Res 1997 Aug;289(9):540-6
ISIS 3521  151879-73-1   *Thionucleotides Protein Kinase C/antagonists & inhibitors. Cancer Res 1996 Aug 1;56(15):3499-507
BRS1 compound  0   *Amino Alcohols *Fatty Alcohols Protein Kinase C/antagonists & inhibitors. Toxicon 1997 Jul;35(7):1125-9
protein kinase C (15-28)  0   *Peptide Fragments *Protein Kinase C. Pept Res 1996 Sep-Oct;9(5):229-32
InaC protein, Drosophila  EC 2.7.1.-   *Eye Proteins *Protein Kinase C *Drosophila Proteins. EMBO J 1996 Dec 16;15(24):7036-45
prostate apoptosis response-4 protein  0   *Apoptosis Regulatory Proteins Protein Kinase C Apoptosis. Cell 1996 Sep 6;86(5):777-86
decursin  5928-25-6   *Benzopyrans *Butyric Acids Protein Kinase C/agonists. Planta Med 1996 Feb;62(1):7-9
ruboxistaurin  169939-94-0   *Indoles *Maleimides Protein Kinase C/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Science 1996 May 3;272(5262):728-31
C1 peptide  0   *Glycogen Synthase *Peptide Fragments Protein Kinase C. Cell Signal 1995 Aug;7(6):635-42
PKCA protein, Aspergillus niger  EC 2.7.1.-   *Fungal Proteins *Protein Kinase C. Mol Gen Genet 1996 Jan;250(1):17-28
Pkc1 protein, Trichoderma reesei  EC 2.7.1.-   *Fungal Proteins *Protein Kinase C Protein Kinase C. Mol Gen Genet 1996 Jan;250(1):17-28
debromohymenialdisine  125118-55-0   *Azepines *Pyrroles Protein Kinase C/antagonists & inhibitors. Inflamm Res 1995 Aug;44 Suppl 2:S123-4
6-benzoyl-6-deacetylmayteine  133740-16-6   *Lactones *Pyridines Protein Kinase C/antagonists & inhibitors. Planta Med 1995 Aug;61(4):390
mayteine  104736-05-2   *Lactones *Pyridines Protein Kinase C/antagonists & inhibitors. Planta Med 1995 Aug;61(4):390
balmoralmycin  0   *Anthracyclines Protein Kinase C/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Jun;48(6):457-61
dihydrolicoisoflavone  0   *Isoflavones Protein Kinase C/antagonists & inhibitors. J Nat Prod 1995 Apr;58(4):629-32
corallidictyal A  160632-45-1   *Sesquiterpenes Protein Kinase C/antagonists & inhibitors Stereoisomerism. J Nat Prod 1994 Nov;57(11):1543-8
protein kinase D  EC 2.7.10.-   *Protein Kinase C. Proc Natl Acad Sci U S A 1994 Aug 30;91(18):8572-6
azepinostatin  0   *Azepines *Hydroxybenzoic Acids Protein Kinase C/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Jun;47(6):639-47
protein kinase C beta  EC 2.7.1.-   *Protein Kinase C Isoenzymes. J Biol Chem 1994 Jul 29;269(30):19578-84
ZB14 protein, Zea mays  0   *Carrier Proteins *Plant Proteins Protein Kinase C/antagonists & inhibitors. Biochim Biophys Acta 1994 Jun 30;1222(2):306-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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