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Histone-Lysine N-Methyltransferase

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Definition: An enzyme that catalyzes the methylation of the epsilon-amino group of lysine residues in proteins to yield epsilon mono-, di-, and trimethyllysine. EC 2.1.1.43.      Other names Protein Methyltransferase III; Protein Methylase III; Protein Lysine Methyltransferase; N-Methyltransferase, Histone-Lysine; Methyltransferase, Protein Lysine; Methyltransferase, Histone-Lysine; Histone Lysine N Methyltransferase; Histone Lysine Methyltransferase; Histone-Lysine Methyltransferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Setd8 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. EMBO J. 2012 Feb 1;31(3):616-29
Suv4-20h protein, mouse  EC 2.1.1.125   *Histone-Lysine N-Methyltransferase. PLoS One. 2011;6(10) (dup#6):e25680
AZ 505  0   *Benzoxazines beta-Alanine/*analogs & derivatives Histone-Lysine N-Methyltransferase/antagonists & inhibitors. Structure. 2011 Sep 7;19(9):1262-73.
UNC 0638  0   *Quinazolines Histone-Lysine N-Methyltransferase/antagonists & inhibitors. Nat Chem Biol 2011;7(8):499-500
Setd3 protein, zebrafish  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Zebrafish Proteins. Biosci Biotechnol Biochem 2011;75(2):289-94
LAZ2 protein, Arabidopsis  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Arabidopsis Proteins. PLoS Pathog 2010;6(10):pii:e1001137
ASH-2 protein, C elegans  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Caenorhabditis elegans Proteins. Nature. 2010 Jul 15;466(7304):383-7
Setdb2 protein, zebrafish  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Zebrafish Proteins. Proc Natl Acad Sci U S A 2010 Feb 9;107(6):2521-6
BRE2 protein, S cerevisiae  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Saccharomyces cerevisiae Proteins. J Biol Chem 2010 Jan 1;285(1):595-607
SDC1 protein, S cerevisiae  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Saccharomyces cerevisiae Proteins. J Biol Chem 2010 Jan 1;285(1):595-607
PRDM9 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. J Androl. 2009 Jul-Aug;30(4):426-31
PRDM8 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Biochem Biophys Res Commun 2009 Oct 9;388(1):131-6
Su(z)12 protein, Drosophila  0   *Histone-Lysine N-Methyltransferase *Repressor Proteins *Drosophila Proteins.
esc protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins.
WHSC1 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Nature. 2009 Jul 9;460(7252):287-91
SUV420H2 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. BMC Cell Biol 2009;10:41
SETD7 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase.
MLL5 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Blood 2009 Feb 12;113(7):1432-43
prdm9 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Science. 2009 Jan 16;323(5912):350-1
G9a protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Mamm Genome 2001 Dec;12(12):916-24
SET8 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. J Biol Chem 2008 Apr 25;283(17):11073-7
Set2 protein, S pombe  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Schizosaccharomyces pombe Proteins. Nature. 2008 Feb 7;451(7179):734-7
Mes-4 protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. EMBO J 2007 Dec 12;26(24):4974-84
Hypb protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. EMBO J 2007 Dec 12;26(24):4974-84
Setd1A protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Mol Cell Biol 2008 Jan;28(2):609-18
G9a histone methyltransferase, mouse  EC 2.1.1.-   *Histone-Lysine N-Methyltransferase. Genes Dev 2002 Jul 15;16(14):1779-91
PRC2 protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. Genes Dev 2002 Nov 15;16(22):2893-905
Met-2 protein, C elegans  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Caenorhabditis elegans Proteins. Development 2007 Aug;134(16):2991-9
Met-1 protein, C elegans  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Caenorhabditis elegans Proteins. Development 2007 Aug;134(16):2991-9
Set2 protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. Biochem Biophys Res Commun 2007 Aug 3;359(3):784-9
Set2 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. J Biomol NMR 2006;36 Suppl 1:5
dEset protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. Hereditas 2006 Dec;143(2006):177-88
Lid protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins DNA-Binding Proteins Transcription Factors. Genes Dev 2007 Mar 1;21(5):537-51
BIX 01294  0   *Azepines *Quinazolines Histone-Lysine N-Methyltransferase/antagonists & inhibitors. Mol Cell 2007 Feb 9;25(3):473-81
MLL4 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Proc Natl Acad Sci U S A 2006 Oct 17;103(42):15392-7
Rkm2 protein, S cerevisiae  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Saccharomyces cerevisiae Proteins. J Biol Chem 2006 Nov 24;281(47):35835-45
SUV39H2 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Carcinogenesis 2006 Nov;27(11):2217-22
SUVR4 protein, Arabidopsis  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Arabidopsis Proteins. Nucleic Acids Res 2001 Nov 1;29(21):4319-33
SUVH3 protein, Arabidopsis  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Arabidopsis Proteins. J Exp Bot 2006;57(12):3301-11
GLP protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Genes Dev 2005 Apr 1;19(7):815-26
Smyd2 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase. Mol Cancer 2006;5:26
SMYD2 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase Zinc Fingers. Mol Cancer 2006;5:26
Suv4-20h2 protein, rat  EC 2.1.1.125   *Histone-Lysine N-Methyltransferase Histone-Lysine N-Methyltransferase. Carcinogenesis 2006 Jun;27(6):1180-6
Suv39h1 protein, rat  EC 2.1.1.   *Methyltransferases *Repressor Proteins Phosphoproteins Histone-Lysine N-Methyltransferase. Carcinogenesis 2006 Jun;27(6):1180-6
SmyD1 protein, zebrafish  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Zebrafish Proteins. Proc Natl Acad Sci U S A 2006 Feb 21;103(8):2713-8
MLL3 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase Zinc Fingers. Gene 2006 Apr 12;371(1):25-33
SETMAR protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase DNA Repair. Proc Natl Acad Sci U S A 2005 Dec 13;102(50):18075-80
SUVH6 protein, Arabidopsis  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Arabidopsis Proteins. Nucleic Acids Res 2001 Nov 1;29(21):4319-33
SMYD3 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase DNA-Directed RNA Polymerases Zinc Fingers. Nat Cell Biol 2004 Aug;6(8):731-40
Rkm1 protein, S cerevisiae  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Oct 14;280(41):34590-8
WDR5 protein, human  0   *Histone-Lysine N-Methyltransferase. Cell 2005 Jun 17;121(6):859-72
SUVH2 protein, Arabidopsis  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Arabidopsis Proteins. EMBO J 2005 Apr 6;24(7):1418-29
Suv39h1 protein, mouse  EC 2.1.1.   *Methyltransferases *Repressor Proteins Phosphoproteins Histone-Lysine N-Methyltransferase.
Ezh2 protein, mouse  EC 2.1.1.-   *Histone-Lysine N-Methyltransferase.
Ezh1 protein, mouse  EC 2.1.1.43   *DNA-Binding Proteins *Histone-Lysine N-Methyltransferase *Transcription Factors.
PR-Set7 protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. Genes Dev 2005 Feb 15;19(4):431-5
Prdm2 protein, mouse  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Transcription Factors. Mol Cell Biol 2004 Aug;24(16):7032-42
Suv4-20 protein, Drosophila  EC 2.1.1.-   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. Genes Dev 2004 Jun 1;18(11):1251-62
SWD2 protein, S cerevisiae  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2004 Apr;24(7):2932-43
TRR protein, Drosophila  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase *Drosophila Proteins. Nature 2003 Nov 6;426(6962):78-83
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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