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Protein Synthesis Inhibitors

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Definition: Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.  enzyme inhib; DF: PROTEIN SYN INHIB    Other names Protein Synthesis Antagonists; Inhibitors, Protein Synthesis; Antagonists, Protein Synthesis
Substances having this pharmacologic action: 2',5'-oligoadenylate; pokeweed antiviral protein; GEL protein, Gelonium multiflorum; MITF protein, Aspergillus restrictus; Brefeldin A; Shiga Toxins; Oxazolidinones; tempol; Ribosome Inactivating Proteins; Lincosamides; halofuginone; S-2-aminoethyl cysteine; sordarin; Anisomycin; Chloramphenicol; Chlortetracycline; Clindamycin; Lincomycin; Neomycin; Netilmicin; Sisomicin; Puromycin; Sparsomycin; Streptomycin; Tetracycline; Mupirocin; Clarithromycin; Viomycin; Virginiamycin; Erythromycin Ethylsuccinate; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Olivomycins; Pactamycin; Methylazoxymethanol Acetate; Fusidic Acid; Gentamicins; Cycloheximide; Emetine; Plicamycin; Erythromycin; Erythromycin Estolate; Capreomycin; Dactinomycin; Kanamycin; Amino Acid Chloromethyl Ketones; trichostatin A; Cibacron Blue F 3GA; alpha-sarcin; linezolid; quinupristin-dalfopristin; ranpirnase; saporin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
momorgrosvin protein, Siraitia grosvenorii  EC 3.2.2.22   *N-Glycosyl Hydrolases *Plant Proteins Protein Synthesis Inhibitors. Life Sci. 2001 Jan 5;68(7):773-84
cethromycin  0   *Ketolides Protein Synthesis Inhibitors RNA, Ribosomal, 23S.
Pharma Action Anti-Bacterial Agents 		Antimicrob Agents Chemother 2000 Feb;44(2):447-9
telithromycin  0   *Ketolides Protein Synthesis Inhibitors RNA, Ribosomal, 23S.
Pharma Action Anti-Bacterial Agents 		Diagn Microbiol Infect Dis 1997 Jan-Feb;27(1-2):7-12; The Annals of Pharmacotherapy 2002 36:452-64KETEK
PD-S2 protein, Phytolacca dioica  EC 3.2.2.22   *Ribosome Inactivating Proteins, Type 1 Protein Synthesis Inhibitors. Biochim Biophys Acta 1997 Mar 7;1338(1):137-44
CLA protein, Aspergillus clavatus  EC 3.1.27.-   *Fungal Proteins *Ribonucleases Protein Synthesis Inhibitors. Eur J Biochem 1996 Jul 15;239(2):272-80
Tricholin protein, Trichoderma viride  0   *Fungal Proteins Protein Synthesis Inhibitors. J Antibiot (Tokyo) 1994 Jul;47(7):799-805
mukF protein, E coli  0   *Escherichia coli Proteins Protein Synthesis Inhibitors. Mol Gen Genet 1994 Apr;243(2):136-47
picornain 2A, Picornavirus  EC 3.4.22.29   *Cysteine Endopeptidases *Viral Proteins Protein Synthesis Inhibitors Nucleic Acid Synthesis Inhibitors. J Virol 1988;62(11):4216
volkensin  91933-11-8 Volkensin  *Ribosome Inactivating Proteins, Type 2 Protein Synthesis Inhibitors. J Biol Chem 1985;260(27):14589

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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