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Prothrombin

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Definition: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.  a blood coag factor; an enzyme precursor   
See Also Coagulants 		Other names Factor II; Coagulation Factor II; II, Coagulation Factor; Factor, Differentiation Reversal; Factor II, Coagulation; Differentiation Reversal Factor; Blood Coagulation Factor II
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
factor IX, factor VII, factor X, prothrombin drug combination  0   *Factor IX *Factor VII *Factor X *Prothrombin Drug Combinations. Thomb Haemost 2007 oct;98(4):790-7
insularinase A, Bothrops insularis  EC 3.4.-   *Crotalid Venoms *Metalloproteases Prothrombin/agonists. Biol Chem 2005 Jun;386(6):589-600
prothrombin Scranton  0   *Prothrombin. Thromb Haemost 2001 Apr;85(4):651-4
prothrombin (1-46), Trp(4)  0   *Peptide Fragments *Prothrombin. J Biol Chem 2001 Jun 29;276(26):23895-902
prothrombin San Antonio  0   *Prothrombin. Blood 2000 Jan 15;95(2):711-4
trocarin  0   *Prothrombin Elapid Venoms. Blood 1999 Jul 15;94(2):621-31
prothrombin Greenville  0   Prothrombin/*analogs & derivatives. Blood 1998 Mar 15;91(6):2026-31
prothrombin (35-62)  0   *Peptide Fragments *Prothrombin. Int J Pept Protein Res 1996 Aug;48(2):139-47
prothrombin Frankfurt  0   Prothrombin/*analogs & derivatives. Thromb Haemost 1995 Feb;73(2):203-9
Preconativ  60005-85-8 Preconativ  *Factor IX *Factor X *Prothrombin Drug Combinations. Thromb Res 1993 Aug 1;71(3):175-84
prothrombin Himi  0   *Prothrombin. Thromb Res 1991;62(6):697
prothrombin, Gla(9)  0   Prothrombin/*analogs & derivatives. Biochem Cell Biol 1990;68(4):705
prothrombin (des 1-44)  0   *Peptide Fragments *Prothrombin. Biochimie 1989;71(1):175
prothrombin Magdeburg  0   *Prothrombin. Dtsch Med Wochenschr 1989;114(8):288
prothrombin (1-45)  122168-64-3   *Peptide Fragments *Prothrombin. J Biol Chem 1988;263(28):14216
prothrombin Salakta  0   *Prothrombin Coagulation Protein Disorders. Blood 1988;71(3):556
factor II clotting antigen  0   *Antigens *Prothrombin. Pediatrics 1988;81(3):423
prothrombin Poissy  0   *Prothrombin Coagulation Protein Disorders. Br J Haematol 1987;66(2):239
chemotactic peptide CB67-129  0   *Peptide Fragments *Prothrombin. J Cell Physiol 1987;131(2):255
prothrombin activator protein, Bothrops atrox venom  EC 3.4.24.-   *Metalloendopeptidases Crotalid Venoms Proteins Prothrombin. Biochemistry 1987;26(3):772
prothrombin Perija  0   *Prothrombin Coagulation Protein Disorders. Thromb Res 1986;44(5):587
prothrombin Tokushima  0   *Prothrombin. Blood 1987;69(2):565
prothrombin precursor (13-29)  105931-25-7   *Peptide Fragments *Protein Precursors *Prothrombin. J Med Chem 1987;30(2):445
prothrombin Clamart  105418-28-8 Prothrombin Clamart  *Prothrombin. Thromb Res 1986;44(1):11
prothrombin Barcelona  0   *Prothrombin. J Biol Chem 1986;261(32):15045
prothrombin fragment 1.2.3  0   *Peptide Fragments *Prothrombin. J Biol Chem 1986;261(28):13210
prothrombin (18-23)  103658-53-3   *Peptide Fragments *Prothrombin Peptides, Cyclic. Int J Pept Protein Res 1986;27(5):530
prothrombin fragment 1.2  0   *Peptide Fragments *Prothrombin. Thromb Res 1985;38(4):375
prothrombin fragment 2  78768-79-3 Blood-coagulation factor II, fragment 2  *Peptide Fragments *Prothrombin. Br J Haematol 1984;58(4):597
prothrombin Metz  0   *Prothrombin Coagulation Protein Disorders. Blood 1984;63(4):927
prothrombin habana  0   *Prothrombin Hypoprothrombinemias. Br J Haematol 1983;54(4):553
prothrombin type 3  0   *Prothrombin. Br J Haematol 1983;54(2):245
acetylcysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine methyl ester cyclic disulfide  79397-11-8 L-Cysteine, N-acetyl-L-cysteinyl-L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-prolyl-, 6-methyl ester, cyclic (1-6)-disulfide  *Peptide Fragments *Prothrombin. Int J Pept Protein Res 1981;18(1):41
cysteinyl-leucyl-glutamyl-glutamyl-prolyl-cysteine cyclic disulfide  72903-48-1 L-Cysteine, L-cysteinyl-L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-prolyl-, cyclic (1-6)-disulfide  *Peptide Fragments *Prothrombin. Int J Pept Protein Res 1981;18(1):41
prothrombin residue (1-39)  79177-29-0   *Peptide Fragments *Prothrombin. J Biol Chem 1981;256(15):7863
prothrombin fragment 1  72270-84-9 Blood-coagulation factor II, fragment 1  *Peptide Fragments *Protein Precursors *Prothrombin. Biochim Biophys ACTA 1981;667(1):35
Factor IIa  9002-04-4   *Prothrombin. J Lab Clin Med 1980;95(6):783
prothrombin activator (Taipan venom)  0   *Peptide Hydrolases *Prothrombin Elapid Venoms Enzyme Activation. Biochemistry 1980;19(5):1020
preprothrombin carboxylase  EC 4.1.1.-   *Carboxy-Lyases Protein Precursors Prothrombin. J Biol Chem 252(21):7738;1977
prethrombins  9070-19-3 Thrombin, pre  *Prothrombin. Eur J Biochem 1980;104(2):549; J Biol Chem 252(14):4942;1977; Thromb Res 8(1):83;1976
acarboxyprothrombin  53230-14-1 pre-blood-coagulation factor II  *Protein Precursors *Prothrombin *Biological Markers. Biochem Biophys Res Commun 54(3):1075;1973; Thromb Haemost 1979;42(4):1296

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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