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Proto-Oncogene Proteins

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Definition: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.  GEN or unspecified; prefer specifics; /drug eff /ultrastruct permitted; DF: note short X ref   
Examples Chemokine CXCL1; Cyclin D1; Fibroblast Growth Factor 4; Fibroblast Growth Factor 6; fms-Like Tyrosine Kinase 3; Janus Kinase 2; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MutS Homolog 2 Protein; Myeloid-Lymphoid Leukemia Protein; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-bcl-6; Proto-Oncogene Proteins c-bcr; Proto-Oncogene Proteins c-cbl; Proto-Oncogene Proteins c-crk; Proto-Oncogene Proteins c-ets; Proto-Oncogene Proteins c-fes; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-hck; Proto-Oncogene Proteins c-jun; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-maf; Proto-Oncogene Proteins c-mdm2; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-mos; Proto-Oncogene Proteins c-myb; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-pim-1; Proto-Oncogene Proteins c-rel; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins c-sis; Proto-Oncogene Proteins c-vav; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins p21(ras); Proto-Oncogene Proteins pp60(c-src); raf Kinases; Receptor, erbB-2; Receptor, erbB-3; Receptor, Fibroblast Growth Factor, Type 3; Receptor, Macrophage Colony-Stimulating Factor; Receptors, Thyroid Hormone; RNA-Binding Protein EWS; RNA-Binding Protein FUS; Stathmin; Wnt1 Protein; Wnt2 Protein 		Other names c-onc Proteins; Cellular Proto-Oncogene Proteins; c onc Proteins; Proto-Oncogene Proteins, Cellular; Proto Oncogene Proteins; Proto Oncogene Products, Cellular; Cellular Proto-Oncogene Products; Cellular Proto Oncogene Proteins; Proto-Oncogene Products, Cellular; Proto Oncogene Proteins, Cellular
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MYCN protein, mouse  0   *Proto-Oncogene Proteins. Sci Transl Med. 2012 Jan 4;4(115):115ra3.
PSMD10 protein, Danio rerio  0   *Proto-Oncogene Proteins *Zebrafish Proteins *Proteasome Endopeptidase Complex. Biochim Biophys Acta. 2011 Sep;1811(9):536-48
DCUN1D1 protein, mouse  0   *Proto-Oncogene Proteins. J Biol Chem. 2011 Mar 25;286(12); 10297-304
puma protein, zebrafish  0   *Proto-Oncogene Proteins *Zebrafish Proteins *Apoptosis Regulatory Proteins. Dev Biol. 2010 Oct 15;346(2); 296-309
Tet3 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins Zinc Fingers. Nature. 2010 Aug 26;466(7310):1129-33
Tet2 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins Zinc Fingers. Nature. 2010 Aug 26;466(7310):1129-33
CCM3 protein, zebrafish  0   *Membrane Proteins *Proto-Oncogene Proteins *Zebrafish Proteins *Apoptosis Regulatory Proteins. Hum Mutat. 2009 Jun;30(6); 1003-11
TET2 protein, human  0   *DNA-Binding Proteins *Proto-Oncogene Proteins Zinc Fingers. N Engl J Med 2009 May 28;360(22):2289-301
TET1 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins Zinc Fingers. Science. 2009 May 15;324(5929):930-5
LSm1 protein, rat  0   *Proto-Oncogene Proteins *RNA-Binding Proteins. J Cell Biol 2009 Feb 9;184(3):423-35
Ski protein, rat  0   *Proto-Oncogene Proteins. J Cell Biol 2008 Aug 11;182(3):519-30
Elk3 protein, human  0   *Proto-Oncogene Proteins *Transcription Factors. Cancer Res 2008 Mar 1;68(5):1275-83
Bhd protein, mouse  0   *Proto-Oncogene Proteins *Tumor Suppressor Proteins. J Natl Cancer Inst 2008 Jan 16;100(2):140-54
c-ski protein, rat  0   *Proto-Oncogene Proteins. Biochem J 2008 Jan 1;409(1):289-97
DCUN1D1 protein, human  0   *Proto-Oncogene Proteins. Cancer Res 2006 Oct 1;66(19):9437-44
Pet1 protein, zebrafish  0   *Transcription Factors *Zebrafish Proteins Proto-Oncogene Proteins. Dev Dyn 2007 Apr;236(4):1072-84
Ahi-1 protein, zebrafish  0   *Carrier Proteins *Zebrafish Proteins Proto-Oncogene Proteins Zinc Fingers. Mol Biol Rep 2006 Jun;33(2):111-6
neutrophil gelatinase-associated lipocalin protein, rat  0   *Acute-Phase Proteins *Proto-Oncogene Proteins *Lipocalins. Am J Pathol 2006 Dec;169(6):2245-53
BHD protein, Drosophila  0   *Proto-Oncogene Proteins *Drosophila Proteins Tumor Suppressor Proteins. Oncogene 2006 Sep 28;25(44):5933-41
Nrz protein, zebrafish  0   *Proto-Oncogene Proteins *Zebrafish Proteins. Cell Death Differ. 2006 Jul;13(7):1128-37
Ski protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins.
FUSSEL18 protein, human  0   *Nerve Tissue Proteins *Proto-Oncogene Proteins. Lab Invest 2005 Nov;85(11):1330-41
Nix protein, rat  0   *Membrane Proteins *Proto-Oncogene Proteins. J Cereb Blood Flow Metab 2005 Oct;25(10):1356-65
BNIP3 protein, rat  0   *Membrane Proteins *Proto-Oncogene Proteins. Am J Physiol Gastrointest Liver Physiol 2005 Nov;289(5):G822-30
CaSm protein, mouse  0   *Proto-Oncogene Proteins Pancreatic Neoplasms. Mol Ther 2005 Mar;11(3):363-72
Nmyc1 protein, zebrafish  0   *Proto-Oncogene Proteins *Zebrafish Proteins DNA-Binding Proteins Phosphoproteins Transcription Factors. Gene Expr Patterns 2005 Feb;5(3):341-7
ARHGEF5 protein, human  0   *Proto-Oncogene Proteins *Guanine Nucleotide Exchange Factors. Cell Signal 2005 Apr;17(4):461-71
Ss18 protein, mouse  0   *Proto-Oncogene Proteins *Repressor Proteins.
PARP10 protein, human  EC 2.4.2.30   *Poly(ADP-ribose) Polymerases *Proto-Oncogene Proteins. Oncogene. 2005 Mar 17;24(12):1982-93
PIM3 protein, human  EC 2.7.1.37   *Proto-Oncogene Proteins *Protein-Serine-Threonine Kinases. Int J Cancer 2005 Mar 20;114(2):209-18
Sfrp4 protein, rat  0   *Proto-Oncogene Proteins.
Sfrp4 protein, mouse  0   *Proto-Oncogene Proteins.
PDCD10 protein, human  0   *Membrane Proteins *Proto-Oncogene Proteins *Apoptosis Regulatory Proteins. Am J Hum Genet. 2005 Jan;76(1):42-51
MTG8 protein, mouse  0   *DNA-Binding Proteins *Proto-Oncogene Proteins *Transcription Factors. Mol Cell Biol. 2004 Nov;24(22):9863-72
Wisp1 protein, mouse  0   *Proto-Oncogene Proteins *CCN Intercellular Signaling Proteins.
Wisp1 protein, rat  0   *Proto-Oncogene Proteins *CCN Intercellular Signaling Proteins.
FRAT1 protein, human  0   *Proto-Oncogene Proteins *Intracellular Signaling Peptides and Proteins.
Ccm1 protein, mouse  0   *Microtubule-Associated Proteins *Proto-Oncogene Proteins Ankyrin Repeat.
Wnt5 protein, Drosophila  0   *Proto-Oncogene Proteins *Drosophila Proteins *Wnt Proteins. Development 1992 Jun;115(2):475-85
Nfkbie protein, mouse  0   *Proto-Oncogene Proteins *I-kappa B Proteins.
Copeb protein, mouse  0   *Proto-Oncogene Proteins *Kruppel-Like Transcription Factors Zinc Fingers.
Copeb protein, rat  0   *Proto-Oncogene Proteins *Kruppel-Like Transcription Factors Zinc Fingers.
WNT10B protein, human  0   *Proto-Oncogene Proteins *Wnt Proteins.
Mertk protein, mouse  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases.
Mertk protein, rat  EC 2.7.1.112   *Proto-Oncogene Proteins *Receptor Protein-Tyrosine Kinases.
Ddx6 protein, mouse  EC 2.7.7.-.   *Proto-Oncogene Proteins *DEAD-box RNA Helicases.
PIM2 protein, human  0   *Proto-Oncogene Proteins *Protein-Serine-Threonine Kinases.
Wnt7a protein, rat  0   *Proto-Oncogene Proteins *Wnt Proteins.
ACP1 protein, human  EC 3.1.3.48   *Proto-Oncogene Proteins *Protein Tyrosine Phosphatases.
Acp1 protein, mouse  EC 3.1.3.48   *Proto-Oncogene Proteins *Protein Tyrosine Phosphatases.
Tcl1 protein, mouse  0   *Proto-Oncogene Proteins.
Pbx2 protein, mouse  0   *Proto-Oncogene Proteins *Homeodomain Proteins Major Histocompatibility Complex.
A-MYB protein, chicken  0   *Proto-Oncogene Proteins *Trans-Activators *Avian Proteins DNA-Binding Proteins.
Shb protein, rat  0   *Proto-Oncogene Proteins.
SHB protein, human  0   *Proto-Oncogene Proteins *Adaptor Proteins, Signal Transducing.
ECT2 protein, human  0   *Proto-Oncogene Proteins Epithelial Cells.
Map3k8 protein, mouse  EC 2.7.11.25   *Proto-Oncogene Proteins *MAP Kinase Kinase Kinases.
LCN2 protein, human  0   *Acute-Phase Proteins *Proto-Oncogene Proteins *Lipocalins.
Bmi1 protein, mouse  0   *Nuclear Proteins *Proto-Oncogene Proteins *Repressor Proteins Zinc Fingers.
Bmi1 protein, rat  0   *Nuclear Proteins *Proto-Oncogene Proteins *Repressor Proteins Zinc Fingers.
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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