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Purines

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Definition: A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.     
Examples Adenine; Allopurinol; 6-Mercaptopurine; Purine Nucleosides; Purine Nucleotides; Purinones; Saxitoxin; Thioguanine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
tegobuvir  0   *Purines *Pyridazines. Antimicrob Agents Chemother. 2011 Sep;55(9):4196-203.
CC-359  0   *Purines MAP Kinase Kinase 4/antagonists & inhibitors. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1427-32.
4-(9-(tetrahydrofuran-3-yl))-8-(2,4,6-trifluorophenylamino)-9H-purin-2-ylaminocyclohexan-1-ol  0   *Cyclohexanols *Purines JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors. Am J Nephrol. 2011;34(4):337-46.
N-((3-(3-9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)furan-3-sulfonamide  0   *Purines *Sulfonamides. Biochem Biophys Res Commun. 2012 Jan 13;417(2):857-63.
3-((tetrahydrofuran-2-yl)methyl)-2-thioxo-7H-purin-6-one  0   *Purines *Thiones Peroxidase/antagonists & inhibitors. Am J Respir Crit Care Med. 2012 Jan 1;185(1):34-43.
GSK 977779  0   *Oxadiazoles *Purines. Drug Metab Dispos. 2011 Sep;39(9):1620-32.
PH006 compound  0   *Purines. Breast Cancer Res Treat. 2011 Nov;130(1):85-96
Linagliptin  0   *Purines *Quinazolines.
Pharma Action Dipeptidyl-Peptidase IV Inhibitors 		TRADJENTA; JENTADUETO
4-allyl-8-ethyl-7,8-dihydro-2-(3-methoxy-1-methyl-1H-pyrazol-5-yl)-1H-imidazo(2,1-i)purin-5(4H)-one  0   *Purines Receptor, Adenosine A3 Purinergic P1 Receptor Antagonists. J Med Chem 2011 Jul 28;54(14):5205-20
N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine  0   *Indoles *Purines Receptors, Aryl Hydrocarbon/antagonists & inhibitors. J Pharmacol Exp Ther 2011 Jul;338(1):318-27
6-benzylamino-7H-purin-3-ium p-toluenesulfonate  0   *Purines *Benzenesulfonates. Acta Crystallogr C. 2011 May;67(Pt 5):o192-4
N-(4-aminosulfonylphenyl)-2-morpholino-9H-purin-6-amine  0   *Morpholines *Purines. Bioorg Med Chem. 2010 Jul 1;18(13):4615-24
2,6-dichloro-9-(1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)-9H-purine  0   *Oxazepines *Purines. Eur J Med Chem 2011 Jan;46(1):249-58
diethyl (6-amino-9H-purin-9-yl) methylphosphonate  0   *Phosphonic Acids *Purines. Free Radic Res. 2010 Aug;44(8):881-90
4-fluoro-4-(1,2,3,6-tetrahydro-1,3-dimethyl-2-oxo-6-thionpurin-8-ylthio)butyrophenone  0   *Butyrophenones *Purines Estrogen Receptor alpha/antagonists & inhibitors. J Biol Chem 2010 Dec 31;285(53):41863-73
Gpact-11a compound  0   *Purines *Pyrimidines Cystic Fibrosis Transmembrane Conductance Regulator/agonists. Eur Respir J 2010 Aug;36(2):311-22
2-phenyl-9H-purine-6-carbonitrile  0   *Nitriles *Purines. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4447-50
CAL 101  0   *Purines *Quinazolinones Phosphatidylinositol 3-Kinases/antagonists & inhibitors. Blood 2010 Sep 2;116(9):1460-8
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide  0   *Acetanilides *Purines Transient Receptor Potential Channels/antagonists & inhibitors. Mol Pain 2008 Oct 27;4:48
StemRegenin 1  0   *Purines. Science. 2010 Sep 10;329(5997):1345-8
4-(2-chloro-6-(3-chlorobenzylamino)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo(3.1.0)hexane-1-carboxamide  0   *Purines Receptor, Adenosine A3. Exp Eye Res 2010 Sep;91(3):425-32
3-(2-chlorobenzyl)-1,7-dimethyl-1H-imidazo(2,1-f)purine-2,4(3H,8H)-dione  0   *Imidazoles *Purines. Biochem Biophys Res Commun 2010 Aug 20;399(2):268-73
10,13-dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one  0   *Diterpenes *Purines Janus Kinase 3/antagonists & inhibitors. Mol Cancer 2010;9:36
N-benzyl-N-methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide  0   *Acetamides *Purines Carbon Radioisotopes. Nucl Med Biol. 2009 Oct;36(7):801-9
6-bromo-7-methylpurine  0   *Purines Carbon Radioisotopes. J Med Chem 2009 Nov 26;52(22):7284-8
4-(6'-thiopurine)-7-chloroquinoline  0   *Purines *Quinolines. Chem Biol Drug Des 2009 Oct;74(4):434-7
N-(4-methoxybenzyl)-N-methyl-9H-purine-2,6-diamine  0   *Purines. Mol Biosyst 2009 Jun;5(6):609-11
N-cyclopentyl-N-(4-methoxybenzyl)-9-methyl-9H-purine-2,6-diamine  0   *Purines. Mol Biosyst 2009 Jun;5(6):609-11
1,3-dibutyl-7-(hydroxypropyl)-1H-purine-2,6(3H,7H)-dione  0   *Purines. Chirality 2009 Aug;21(8):713-8
(2R,3R,4R)-2-(2-chloro-6-(3-bromobenzylamino)-9H-purin-9-yl)-tetrahydrofuran-3,4-diol  0   *Furans *Purines. Bioorg Med Chem 2009 May 15;17(10):3733-8
6-(3-hydroxybenzylamino)-9-tetrahydropyran-2-ylpurine  0   *Purines *Pyrans. Bioorg Med Chem. 2009 Mar 1;17(5):1938-47
6-(3-hydroxybenzylamino)-9-tetrahydrofuran-2-ylpurine  0   *Furans *Purines. Bioorg Med Chem. 2009 Mar 1;17(5):1938-47
1-(9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl)-4-ethylaminopiperidine-4-carboxylic acid amide  0   *Piperidines *Purines Receptor, Cannabinoid, CB1/antagonists & inhibitors. J Med Chem 2009 Jan 22;52(2):234-7
UK-371,800  0   *Piperazines *Purines *Sulfones Erectile Dysfunction/drug therapy. Bioorg Med Chem Lett 2008 Dec 1;18(23):6033-6
CR8 compound  0   *Purines *Pyridines Cyclin-Dependent Kinases/antagonists & inhibitors. Oncogene. 2008 Oct 2;27(44):5797-807
2-amino-deoxyribosylpurine  0   *Purines Fluorescent Dyes. J Phys Chem B 2008 Aug 14;112(32):9736-45
GS-9219  0   *Purines Alanine/*analogs & derivatives. Clin Cancer Res 2008 May 1;14(9):2824-32
cis-((7-(6-chloro-9H-purin-9-yl)methyl)-2,3-diphenyl-6,7-dihydro-5H-cyclopenta(b)pyrazin-5-yl)methanol  0   *Purines *Pyrazines. Chem Pharm Bull (Tokyo) 2008 May;56(5):626-34
Regulatory particle-Inhibiting Peptoid-1  0   *Indoles *Purines. Chem Commun (Camb). 2008 Mar 7;(9):1064-6
6-(3'-(thioethylamine)propylthio)purine  0   *Ethylamines *Purines. Eur J Med Chem. 2007 Apr;42(4):530-7
6-(6'-deoxy-1'-O-methyl-beta-D-ribofuranose)purine  0   *Purines. Eur J Med Chem. 2007 Apr;42(4):530-7
6-(3'-chloropropylthio)purine  0   *Purines. Eur J Med Chem. 2007 Apr;42(4):530-7
PU H71  0   *Purines *Benzodioxoles HSP90 Heat-Shock Proteins/antagonists & inhibitors. Cancer Res 2008 Jan 1;68(1):216-26
GI270384X  0   *Polyethylene Glycols *Purines. Am J Physiol Gastrointest Liver Physiol 2007 Oct;293(4):G739-48
2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl)purine  0   *Purines Fluorine Radioisotopes. Nucl Med Biol 2007 Aug;34(6):717-25
9-oxo-imidazo(1,2-a)purine  0   *Imidazoles *Purines. J Phys Chem A 2006 Sep 28;110(38):11025-33
(2R,3R,4S,5R)-2-(6-amino-2-(((1S)-2-hydroxy-1-(phenylmethyl)ethyl)amino)-9H-purin-9-yl)-5-(2-ethyl-2H-tetrazol-5-yl)tetrahydro-3,4-furandiol  0   *Purines *Tetrazoles. Eur J Pharmacol 2007 Jun 14;564(1-3):219-25
6-(2-butylimidazol-1-yl)-2-chloro-9-ethylpurine  0   *Imidazoles *Purines. J Org Chem 2006 Nov 10;71(23):8901-6
lomeguatrib  192441-08-0   *Purines. J Clin Oncol 2007 Jun 20;25(18):2540-5
2-mercaptopurine  0   *Purines *Sulfhydryl Compounds. Biochemistry (Mosc). 2007 Feb;72(2):170-7
QS11 compound  0   *Purines. Proc Natl Acad Sci U S A 2007 May 1;104(18):7444-8
6-chloro-7-methylpurine  0   *Purines. Bioorg Med Chem 2007 May 1;15(9):3127-33
3-ethyl-1-propyl-8-(1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl)-3,7-dihydropurine-2,6-dione  0   *Purines *Pyrazoles. J Pharmacol Exp Ther. 2007 Mar;320(3):1246-51
9-isopropyl-6-(4-methoxy-benzylamino)-9H-purine-2-carboxylic acid isopropylamide  0   *Amides *Purines. Bioorg Med Chem. 2007 Jan 1;15(1):130-41
7,8-dihydro-8-ethyl-2-(4-bicyclo(2.2.2)octan-1-ol)-4-propyl-1H-imidazo(2,1-i)purin-5(4H)-one  0   *Bicyclo Compounds *Purines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2006 Nov 30;49(24):7132-9
7-but-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one  0   *Piperazines *Purines. J Pharmacol Exp Ther. 2006 Dec;319(3):1253-7
7-deazapurine  0   *Purines. Curr Top Med Chem 2006;6(9):867-92
2-amino-6-chloro-9-((5-dihydroxyboryl)pentyl)purine  0   *Purines *Boron Compounds Tumor Necrosis Factor-alpha/antagonists & inhibitors. PLoS Med 2005 Sep;2(9):e245
NSC 45641  0   *Hydrazones *Purines Apoptosis. Proc Natl Acad Sci U S A 2006 Apr 18;103(16):6344-9
8-cyclopentyl-2,6-diphenylpurine  0   *Purines Receptor, Adenosine A1/antagonists & inhibitors. J Med Chem 2006 May 18;49(10):2861-7
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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