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Pyroglutamyl-Peptidase I

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Definition: An enzyme that catalyzes the release of a N-terminal pyroglutamyl group from a polypeptide provided the next residue is not proline. It is inhibited by thiol-blocking reagents and occurs in mammalian tissues, microorganisms, and plants. (From Enzyme Nomenclature, 1992) EC 3.4.19.3.      Other names Pyroglutamyl Peptide Hydrolase; Pyroglutamyl Peptidase I; Peptidase, Pyrrolidonyl; Peptidase, Pyrrolidonecarboxylate; I, Pyroglutamyl-Peptidase; Aminopeptidase, Pyroglutamate; 5 Oxoprolyl Peptidase; Pyroglutamyl-Peptide Hydrolase; Pyrrolidonyl Peptidase; Pyrrolidonecarboxylate Peptidase; Pyroglutamate Aminopeptidase; 5-Oxoprolyl-Peptidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pyrizinostatin  146406-84-0   *Triazines Pyroglutamyl-Peptidase I/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Nov;45(11):1795-6
benarthin  143651-45-0 L-Threonine, N-(N2-(2,3-dihydroxybenzoyl)-L-arginyl)  *Dipeptides Pyroglutamyl-Peptidase I/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Jul;45(7):1079-83
N-1-carboxy-2-phenylethyl(N(im)benzyl)histidyl-beta-naphthylamide  0   *Naphthalenes Pyroglutamyl-Peptidase I/antagonists & inhibitors. Neuropeptides 1989;14(3):191
5-oxoprolinal  96914-00-0   Proline/*analogs & derivatives Pyroglutamyl-Peptidase I/antagonists & inhibitors. Biochemistry 1985;24(15):3907
pyroglutamyl diazomethyl ketone  98151-77-0   Pyrrolidonecarboxylic Acid/*analogs & derivatives Pyroglutamyl-Peptidase I/antagonists & inhibitors. Biochem Biophys Res Commun 1985;130(2):662
N-carbobenzoxypyroglutamyl diazomethyl ketone  81910-23-8 1-Pyrrolidinecarboxylic acid, 2-(diazoacetyl)-5-oxo-, phenylmethyl ester, (S)  Diazomethane/*analogs & derivatives Pyroglutamyl-Peptidase I/antagonists & inhibitors. Biochim Biophys Acta 1982;702(2):149
thyroliberin pyroglutamylpeptidase  EC 3.4.19.-   *Pyroglutamyl-Peptidase I. Biochem Soc Trans 1980;8(4):423

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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