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Pyrrolidines

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Definition:   do not confuse with PYRROLIDONES or PYRROLIDINONES   
Examples Anisomycin; Bepridil; Clemastine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Glycopyrrolate; Imino Furanoses; Kainic Acid; Lincosamides; Nafoxidine; Nitromifene; N-Nitrosopyrrolidine; Pentolinium Tartrate; Procyclidine; Pyrrolidinones; Tremorine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CEP-27088  0   *Pyridazines *Pyrrolidines. Appl Radiat Isol. 2012 Mar;70(3):512-4.
N-tosylpyrrolidine calix(4)pyrrole  0   *Pyrrolidines *Calixarenes. J Org Chem. 2011 Feb 18;76(4):1005-12
undecyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoate  0   *Caproates *Pyrrolidines. Bioorg Med Chem. 2012 Jan 1;20(1):86-95
decyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoate  0   *Caproates *Pyrrolidines. Bioorg Med Chem. 2012 Jan 1;20(1):86-95
promysalin  0   *Pyrrolidines *Salicylamides. Chem Biol. 2011 Oct 28;18(10):1320-30.
KRP-109  0   *Pyrrolidines *Benzoxazines Leukocyte Elastase/antagonists & inhibitors. Pulm Pharmacol Ther. 2011 Dec;24(6):660-5.
2-(2'-(biphenyl-3-ylmethylcarbamoyl)-6,6'-bis(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-4,4'-bipyridine-2-carboxamido)-2-cyclohexylacetic acid  0   *Pyridines *Pyrrolidines CD40 Ligand/antagonists & inhibitors. ACS Chem Biol. 2011 Jun 17;6(6):636-47.
(2S)-N,N'-(disulfanediyldiethane-2,1-diyl)bis(4-(2-pyridin-3-ylpyrrolidin-1-yl)butanamide)  0   *Pyridines *Pyrrolidines. Biochem Pharmacol. 2012 Feb 15;83(4):543-50
3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide  0   *Benzamides *Pyrrolidines Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem. 2011 Dec 8;54(23):8000-12.
3-chloro-4-(4-((2-(3-pyridyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide  0   *Benzamides *Pyrrolidines Receptors, Opioid, kappa/antagonists & inhibitors. J Med Chem. 2011 Dec 8;54(23):8000-12.
PF-429242  0   *Pyrrolidines Arenaviruses, Old World/drug effects. Virology. 2012 Feb 5;423(1):14-22
5-(4-chlorophenyl)-3-methyl-2-(2-(((1-methylethyl)amino)methyl)-1-pyrrolidinyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone  0   *Pyrimidinones *Pyrrolidines Mitogen-Activated Protein Kinase 14/antagonists & inhibitors. Drug Metab Dispos. 2011 Sep;39(9):1668-73.
nifeviroc  0   *Carbamates *Pyrrolidines Receptors, CCR5/antagonists & inhibitors. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4012-4.
3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)-N-(2-methylpropyl)cyclobutanecarboxamide  0   *Cyclobutanes *Pyrrolidines Histamine H3 Antagonists. J Med Chem. 2011 Nov 10;54(21):7602-20.
N-ethyl-3-fluoro-3-(3-fluoro-4-(pyrrolidinylmethyl)phenyl)cyclobutanecarboxamide  0   *Cyclobutanes *Pyrrolidines Histamine H3 Antagonists. J Med Chem. 2011 Nov 10;54(21):7602-20.
2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane  0   *Dioxanes *Pyrrolidines. J Med Chem. 2011 Nov 10;54(21):7588-601.
1-((2-adamantyl)amino)acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride  0   *Nitriles *Pyrrolidines Adamantane/*analogs & derivatives Hypoglycemic Agents Dipeptidyl-Peptidase IV Inhibitors. J Pharmacol Exp Ther. 2012 Jan;340(1):64-72
ivory wave  0   *Lidocaine *Pyrrolidines *Benzodioxoles Drug Combinations Street Drugs. Emerg Med J. 2011 Dec;28(12):1059-60.
PF-3893787  0   *Pyrimidines *Pyrrolidines. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6596-602
3-aminopyrrolidine-4-carboxylic acid  0   *Carboxylic Acids *Pyrrolidines. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6465-9
GW 468816  0   *Pyrrolidines *Quinolines Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. Pharm Res. 2008 Jul;25(7):1531-43.
4-nitrophenyl pyrrolidinemethanol  0   *Nitro Compounds *Pyrrolidines. J Phys Chem A. 2011 Aug 4;115(30):8335-43
GSK 1018921  0   *Benzamides *Pyrrolidines. Clin Pharmacol Ther. 2011 Oct;90(4):597-604.
2-(naphthalene-1-yl)-6-pyrrolidinyl-4-quinazolinone  0   *Pyrrolidines *Quinazolinones. J Pharmacol Exp Ther 2011 Sep;338(3):942-51
6-(4-(3-(2-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-pyridazin-3-one  0   *Pyridazines *Pyrrolidines Receptors, Histamine H3. J Med Chem 2011 Jul 14;54(13):4781-92
O2-vinyl 1-(2-(carboxylato)pyrrolidin-1-yl)diazen-1-ium-1,2-diolate  0   *Pyrrolidines *Triazenes Nitric Oxide Donors. Chem Biol Interact 2011 Aug 15;193(1):88-96
5beta-carboxymethyl-3alpha-hydroxy-2beta-hydroxymethyl-1-methylpyrrolidine  0   *Pyrrolidines Alkaloids. Fitoterapia. 2011 Mar;82(2):247-50
5beta-carboxymethyl-3alpha-hydroxy-2beta-hydroxymethyl-1,1-dimethylpyrrolidine  0   *Pyrrolidines Alkaloids. Fitoterapia. 2011 Mar;82(2):247-50
(2S,4R)-methyl-1-acetyl-4-(N-(4-bromophenyl)sulfamoyloxy)pyrrolidine-2-carboxylate  0   *Pyrrolidines Liver Cirrhosis/drug therapy. Toxicol In Vitro. 2011 Jun;25(4):897-904
2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one  0   *Pyrrolidines *Quinolones. Int J Oncol. 2011 May;38(5):1357-64
tert-butyl-2-(4,5-dihydrogen-4,4,5,5-tetramethyl-3-O-1H-imidazole-3-cationic-1-oxyl-2-pyrrolidine-1-carboxylic ester)  0   *Imidazoles *Pyrrolidines. Chem Biol Interact. 2011 Jul 15;192(3):287-97
2,5-dioxopyrrolidin-1-yl 2-(benzoylsulfanyl)acetate  0   *Acetates *Pyrrolidines *Sulfhydryl Compounds. Acta Crystallogr C. 2011 May;67(Pt 5):o166-70
(2S,4S)-4-Fluoro-1-(((2-hydroxy-1,1-dimethylethyl)amino)acetyl)-pyrrolidine-2-carbonitrile monobenzenesulfonate  0   *Benzenesulfonates *Pyrrolidines. Eur J Pharmacol. 2011 Mar 25;655(1-3):99-107
gosogliptin  869490-23-3   *Pyrimidines *Pyrrolidines Diabetes Mellitus, Type 2/drug therapy Dipeptidyl-Peptidase IV Inhibitors. Diabet Med. 2011 Apr;28(4):464-9
pivaloyloxymethyl(1R,5S,6S)-2-((3S,5S)-5-(N,N-dimethylcarbamoyl)-1-(isobutyryloxymethyloxycarbonyl)pyrrolidin-3-ylthio)-6-((1R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylate  0   *Pyrrolidines *Carbapenems. J Antibiot (Tokyo). 2011 Mar;64(3):233-42
1-((9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl)pyrrolidine  0   *Pyrrolidines. J Nat Prod. 2011 Jan 28;74(1):45-9
methylthio-DADMe-immucillin-A  0   *Pyrrolidines Adenine/*analogs & derivatives. J Biol Chem 2011 Feb 11;286(6):4902-11
broussonetine F  0   *Pyrrolidines Alkaloids. Org Lett. 2011 Feb 18;13(4):616-9
barmumycin  0   *Pyrrolidines. J Org Chem. 2010 Dec 17;75(24):8508-15
2,5-di-(2-phenethyl)pyrrolidine  0   *Pyrrolidines Vesicular Monoamine Transport Proteins/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Dec;335(3):841-51
3,4-methylenedioxypyrovalerone  0   *Pyrrolidines *Benzodioxoles Psychotropic Drugs Designer Drugs. Drug Test Anal 2010 Aug;2(8):377-82
(3R,4R)-4-amino-1-oxyl-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid  0   *Pyrrolidines. Chemistry. 2010 Sep 24;16(36):11160-6
4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol  0   *Naphthols *Pyrrolidines Norepinephrine Plasma Membrane Transport Proteins/antagonists & inhibitors Histamine H3 Antagonists. J Med Chem 2010 Nov 11;53(21):7869-73
3-((2-pyrrolidinyl)methoxy)-5-phenylaminopyridine  0   *Aminopyridines *Pyrrolidines Receptors, Nicotinic. J Med Chem 2010 Oct 14;53(19):6973-85
MK-0489  0   *Pyrrolidines *Spiro Compounds. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4399-405
1-(2-(4-cyclobutyl-(1,4)diazepane-1-carbonyl)-4-(3-fluoro-phenoxy)-pyrrolidin-1-yl)-ethanone  0   *Azepines *Pyrrolidines. J Org Chem. 2010 Jul 2;75(13):4344-55
(4-(4-methoxyphenoxy)-(2,5')bipyrimidinyl-5-yl)pyrrolidin-2-ylmethylamine  0   *Pyrimidines *Pyrrolidines. Pharmacol Biochem Behav 2010 Aug;96(2):130-5
5-fluoro-6-((2-iminopyrrolidin-1-yl)methyl)uracil  0   *Pyrrolidines Uracil/*analogs & derivatives Fluorine Radioisotopes Thymidine Phosphorylase/antagonists & inhibitors. Nucleosides Nucleotides Nucleic Acids 2010 Jan;29(1):49-54
1-benzyl-3-(tert-butyldimethylsilyloxy)-4-(hydroxymethyl)pyrrolidineborane  0   *Boranes *Pyrrolidines. Acta Crystallogr C 2010 Aug;66(Pt 8):o418-20
pandamarilactonine-H  0   *Lactones *Pyrrolidines Alkaloids. Nat Prod. 2010 Aug 27;73(8):1453-5
4-hydroxypyrrolidine  0   *Pyrrolidines. Chemistry. 2010 May 10;16(18):5333-42
4-fluoro-1-(4-fluoro-(4-fluorophenyl)phenylalanyl)-2-pyrrolidinecarbonitrile  0   *Pyrrolidines Phenylalanine/*analogs & derivatives Dipeptidyl Peptidase 4. J Pharm Sci 2010 Jul;99(7):3030-40
PF 877423  0   *Pyrrolidines Adamantane/*analogs & derivatives 11-beta-Hydroxysteroid Dehydrogenases/antagonists & inhibitors. Bioorg Med Chem Lett 2010 May 1;20(9):2897-902
1-(2-(4-cyclobutyl-(1,4)diazepane-1-carbonyl)-4-(3-fluorophenoxy)pyrrolidin-1-yl)ethanone  0   *Azepines *Pyrrolidines Receptors, Histamine H3. Bioorg Med Chem Lett 2010 May 1;20(9):2755-60
2,3,4,5-tetrahydro-4-(2-chlorophenyl)-2-phenyl-6-(pyrrolidin-1-yl)-1,2,4-triazin-5-one  0   *Pyrrolidines *Triazines. Bioorg Med Chem 2010 Mar 1;18(5):1816-21
polyquaternium-6  0   *Polymers *Pyrrolidines. Arch Oral Biol 2010 Jan;55(1):60-7
1-((1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl)carbonyl)-3,5-dimethyl-4-phenylpiperidin-4-ol  0   *Piperidines *Pyrrolidines Receptor, Melanocortin, Type 4/agonists. J Med Chem 2010 Apr 22;53(8):3183-97
4-(benzyloxy)-1-(4-(2-pyrrolidin-1-ylethoxy)phenyl)pyridin-2(3H)-one  0   *Pyridones *Pyrrolidines. Br J Pharmacol 2010 Jan 1;159(2):374-83
N-((4-(biphenyl-2-ylmethoxy)-1-(2-(4-fluorobenzoyl)benzoyl)pyrrolidin-2-yl)methyl)-4-((2,4-dioxothiazolidin-5-ylidene)methyl)benzamide  0   *Pyrrolidines *Thiazolidinediones Group IV Phospholipases A2/antagonists & inhibitors. Inflamm Res 2010 Jan;59(1):53-62
desacetylmicrocolin B  0   *Oligopeptides *Pyrrolidines Lyngbya Toxins. Planta Med. 2009 Oct;75(13):1427-30
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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