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Quinazolines

More information in Books or onNLM PubMed
Definition:      
Examples Prazosin; Quinazolinones; Tetrodotoxin; Trimetrexate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
XL647  0   *Quinazolines *Azabicyclo Compounds Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors Receptor, EphB4/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Clin Cancer Res. 2007 Jun 15;13(12):3713-23.
(-)-(1R,4R)-1,4-(2,3)-indolmethane-1-methyl-2,4-dihydro-1H-pyrazino-(2,1-b)quinazoline-3,6-dione  0   *Quinazolines. Pharm Biol. 2012 Feb;50(2):129-33
4-((4-(3-bromophenylamino)quinazolin-6-ylamino)methyl)phenol  0   *Phenols *Quinazolines. Bioorg Med Chem. 2012 Jan 1;20(1):317-23
CCG-2979  0   *Quinazolines Streptokinase/antagonists & inhibitors. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3469-74.
6,8-dibromo-2-methylquinazoline  0   *Quinazolines. Molecules. 2011;16(12) (dup#14):10187-201
LCH-7749944  0   *Quinazolines Antineoplastic Agents. Cancer Lett. 2012 Apr 1;317(1):24-32
KX2 328  0   *Quinazolines *Benzodioxoles src-Family Kinases/antagonists & inhibitors. Neurosci Res. 2011 Dec;71(4):348-54.
ZR 2003  0   *Nitrogen Mustard Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1135-8.
6-(2-pyridinyl)-5,6-dihydrobenzimidazo(1,2-c)quinazoline  0   *Pyridines *Quinazolines. Analyst. 2011 Nov 21;136(22):4839-45
quinazoline-6-carboxylic acid  0   *Quinazolines Alkaloids. Nat Prod Commun. 2011 Nov;6(11):1595-6
(7R,8S)-7-hydroxy-8-ethoxyrutaecarpine  0   *Quinazolines *Indole Alkaloids Antineoplastic Agents, Phytogenic. J Asian Nat Prod Res. 2011 Oct;13(11):977-83
(7R,8S)-7-hydroxy-8-methoxyrutaecarpine  0   *Quinazolines *Indole Alkaloids Antineoplastic Agents, Phytogenic. J Asian Nat Prod Res. 2011 Oct;13(11):977-83
6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline  0   *Quinazolines Osteosarcoma/drug therapy. Int J Oncol. 2011 Sep;39(3):611-9
farinamycin  0   *Quinazolines. J Nat Prod. 2011 Oct 28;74(10):2265-8
4-(4-chlorophenoxy)-2-trichloromethylquinazoline  0   *Quinazolines. Eur J Med Chem. 2011 Sep;46(9):4184-91.
Linagliptin  0   *Purines *Quinazolines.
Pharma Action Dipeptidyl-Peptidase IV Inhibitors 		TRADJENTA; JENTADUETO
cyclohexyl(2-phenylquinazolin-4-yl)amine  0   *Cyclohexylamines *Quinazolines DNA Topoisomerases, Type I Topoisomerase I Inhibitors. Bioorg Med Chem. 2011 Jul 15;19(14):4399-404.
S-4893 compound  0   *Quinazolines Cytokinins/antagonists & inhibitors. Plant Cell Physiol. 2010 Dec;51(12):2047-59
importazole  0   *Quinazolines. ACS Chem Biol. 2011 Jul 15;6(7):700-8.
AST 1306  0   *Acrylamides *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. PLoS One 2011;6(7):e21487
quinosuaveoline B  0   *Furans *Quinazolines. J Nat Prod. 2008 Nov;71(11):1942-5
quinosuaveoline A  0   *Furans *Quinazolines. J Nat Prod. 2008 Nov;71(11):1942-5
orisuaveoline B  0   *Indoles *Quinazolines. J Nat Prod. 2008 Nov;71(11):1942-5
orisuaveoline A  0   *Indoles *Quinazolines. J Nat Prod. 2008 Nov;71(11):1942-5
5-(1H-benzoimidazol-2-ylmethylsulfanyl)-2-methyl(1,2,4)triazolo(1,5-c)quinazoline  0   *Benzimidazoles *Quinazolines. Bioorg Med Chem Lett 2011 Jun 15;21(12):3738-42
EVP 4593  0   *Phenyl Ethers *Quinazolines. Chem Biol 2011 Jun 24;18(6):777-93
N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine  0   *Quinazolines. J Med Chem 2011 Sep 8;54(17):6139-50
N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine  0   *Quinazolines. J Med Chem 2011 Sep 8;54(17):6139-50
UNC 0638  0   *Quinazolines Histone-Lysine N-Methyltransferase/antagonists & inhibitors. Nat Chem Biol 2011;7(8):499-500
6-fluoro-2-(3-fluorophenyl)-4-(cyanoanilino)quinazoline  0   *Quinazolines. J Orthop Res. 2011 Sep;29(9):1448-56
targocil  0   *Quinazolines *Triazoles. Bioorg Med Chem Lett 2010 Mar 1;20(5):1767-70
4-methyl-N-(4-(8,9,10,11-tetrahydro-6H-azocino(2,1-b)quinazolin-13(7H)-ylideneamino)butyl)-N-(3-(8,9,10,11-tetrahydro-6H-azocino(2,1-b)quinazolin-13(7H)-ylideneamino)propyl)pentanamide  0   *Quinazolines Butyrylcholinesterase Cholinesterase Inhibitors. Bioorg Med Chem 2011 Feb 1;19(3):1222-35
6-(N-(dimethylamino)ethyl)aminobenzo(f)quinazoline  0   *Quinazolines. Bioorg Med Chem 2011 Feb 1;19(3):1197-204
6-(N-(dimethylamino)ethyl)aminobenzo(h)quinazoline  0   *Quinazolines. Bioorg Med Chem 2011 Feb 1;19(3):1197-204
NMS P937  0   *Pyrazoles *Quinazolines. Bioorg Med Chem Lett 2011 May 15;21(10):2969-74
6-bromo-4-allylamino-quinazoline  0   *Allyl Compounds *Quinazolines. FASEB J 2011 Jun;25(6):1934-42
N2,N4-dibenzylquinazoline-2,4-diamine  0   *Quinazolines. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9
2,6-bis(5,6-dihydrobenzo(4,5)imidazo(1,2-c)quinazolin-6-yl)-4-methylphenol  0   *Benzimidazoles *Quinazolines. Inorg Chem. 2011 Feb 21;50(4):1213-9
cottoquinazoline B  0   *Quinazolines Alkaloids. Org Lett. 2011 Mar 4;13(5):1130-3
cottoquinazoline C  0   *Quinazolines Alkaloids. Org Lett. 2011 Mar 4;13(5):1130-3
cottoquinazoline D  0   *Quinazolines Alkaloids. Org Lett. 2011 Mar 4;13(5):1130-3
4-((3-iodophenyl)amino)-7-(2-(2-(2-(2-(2-(2-(18F)fluoroethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)quinazoline-6-yl-acrylamide  0   *Quinazolines Radiopharmaceuticals. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1603-8
HM781-36B  0   *Quinazolines. Cancer Lett. 2011 Mar 28;302(2):155-65
3,4-dihydroquinazoline dihydrochloride  0   *Quinazolines. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6633-6
4-fluoro-2-(4-(4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6,7-dimethoxyquinazolin-2-yl)phenol  0   *Quinazolines. J Med Chem 2011 Jan 27;54(2):580-90
N-(2,6-diethylphenyl)-1-methyl-8-((4-((1-methylpiperidin-4-yl)carbamoyl)-2-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide  0   *Pyrazoles *Quinazolines Protein Kinase Inhibitors. Cancer Res 2010 Dec 15;70(24):10255-64
benzimidazo(1,2-c)quinazolin-6(5h)-thione  0   *Benzimidazoles *Quinazolines *Thiones Anti-Infective Agents. Pak J Pharm Sci. 2010 Oct;23(4):459-62
5-chloro-N'6'-(2,5-dimethoxybenzyl)quinazoline-2,4,6-triamine  0   *Quinazolines. Antimicrob Agents Chemother 2010 Jun;54(6):2603-10
7-(2-(2-(dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine  0   *Azepines *Quinazolines. J Med Chem 2010 Aug 12;53(15):5844-57
LJK 11 compound  0   *Quinazolines. PLoS One 2010;5(5):e10499
2-hydroxy-2-ethyl-(3-carboxylideneamino)-3-(2-(4-methylphenyl))-1,2-dihydroquinazolin-4(3H)-one  0   *Quinazolines. Chem Pharm Bull (Tokyo). 2010;58(5):712-6
GW 583340  0   *Quinazolines *Sulfones. Mol Cancer Ther 2010 May;9(5):1432-42
spiro((2H,3H)quinazoline-2,1'-cyclohexan)-4(1H)-one  0   *Cyclohexanones *Quinazolines. Eur J Med Chem. 2010 Jun;45(6):2117-31
RVX 208  0   *Quinazolines. J Am Coll Cardiol. 2010 Jun 8;55(23):2580-9
N-(3-bromophenyl)-N-(7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)-3,3-dimethylbutanamide  0   *Quinazolines. Invest New Drugs 2010 Apr;28(2):132-8
N,1,4,4-tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide  0   *Pyrazoles *Quinazolines. Mol Cancer Ther 2010 Mar;9(3):673-81
N-(quinazolin-4-yl)-amidine  0   *Amidines *Quinazolines. Chem Pharm Bull (Tokyo). 2010;58(3):369-74
N-(5,6,7,8-tetrahydroquinazolin-4-yl)amidine  0   *Amidines *Quinazolines. Chem Pharm Bull (Tokyo). 2010;58(3):369-74
7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide  0   *Hydroxamic Acids *Quinazolines Histone Deacetylases. J Med Chem 2010 Mar 11;53(5):2000-9
SCH 529074  0   *Piperazines *Quinazolines. J Biol Chem 2010 Apr 2;285(14):10198-212
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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