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Quinuclidines

More information in Books or onNLM PubMed
Definition:      
Examples Quinidine; Quinine; Quinuclidinyl Benzilate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AZD9164  0   *Piperidines *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. Bioorg Med Chem Lett. Dec 15;21(24):7440-6.
3-((((3-fluorophenyl)((3,4,5-trifluorophenyl)methyl)amino)carbonyl)oxy)-1-(2-oxo-2-(2-thienyl)ethyl)-1-azoniabicyclo(2.2.2)octane  0   *Carbamates *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. J Pharmacol Exp Ther 2010 Dec;335(3):622-35
5-(6-(1-azabicyclo(2,2,2)oct-3-yloxy)pyridazin-3-yl)-1H-indole  0   *Indoles *Quinuclidines. J Pharmacol Exp Ther 2010 Sep 1;334(3):863-74
spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine)  0   *Furans *Quinuclidines Receptors, Nicotinic. Biochem Pharmacol 2009 Oct 1;78(7):880-8
N-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)-1-benzofuran-2-carboxamide  0   *Benzofurans *Quinuclidines Receptors, Nicotinic. Biochem Pharmacol 2009 Oct 1;78(7):803-12
SVT-40776  0   *Quinuclidines. Br J Pharmacol 2009 Mar;156(5):807-17
4-(hydroxy(diphenyl)methyl)-1-(2-((phenylmethyl)oxy)ethyl)-1-azoniabicyclo(2.2.2)octane  0   *Benzhydryl Compounds *Quinuclidines Receptor, Muscarinic M3/antagonists & inhibitors. J Med Chem 2009 Apr 23;52(8):2493-505
ATB 107  0   *Quinuclidines *Triazines. FEBS J 2009 Jan;276(1):144-54
2-hydroxymethyl-2-methoxymethylazabicyclo(2.2.2)octan-3-one  0   *Quinuclidines. Oncogene 2005 May 12;24(21):3484-91
2-(pyridin-3-yl)-1-azabicyclo(2.2.2)octane  0   *Pyridines *Quinuclidines Ligands. J Org Chem 2008 Mar 2;73(9):3497-507
(Z)-(+/-)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol  0   *Quinuclidines. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6811-5
(Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one  0   *Quinuclidines. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6811-5
(S)-(1-azabicyclo(2.2.2)oct-3-yl)carbamic acid (S)-1-(2-fluorophenyl) ethyl ester  0   *Carbamates *Quinuclidines. Neurosci Lett. 2007 Apr 6;416(1):61-5
N-(1-azabicyclo(2.2.2)oct-3-yl)-7-(2-(methoxy)phenyl)-1-benzofuran-2-carboxamide  0   *Benzofurans *Quinuclidines Receptors, Nicotinic. J Pharmacol Exp Ther 2007 May;321(2):716-25
CHIR-124  0   *Quinolines *Quinuclidines. Clin Cancer Res 2007 Jan 15;13(2 Pt 1):591-602
maropitant  0   *Quinuclidines. Am J Vet Res 2007 Jan;68(1):48-56
ATI 7505  0   *Benzamides *Quinuclidines Receptors, Serotonin, 5-HT4/agonists. Neurogastroenterol Motil 2007 Jan;19(1):30-8
beta-isocupreidine  0   *Hydroxyquinolines *Quinuclidines. Org Lett 2006 Nov 9;8(23):5357-60
3'-(5-iodothiophen-2-yl)spiro(1-azabicyclo(2.2.2)octane-3,5'-(1',3')oxazolidin)-2'-one  0   *Oxazoles *Quinuclidines Iodine Radioisotopes. Nucl Med Biol 2006 Apr;33(3):311-6
6-(12-(2-fluoromethylpyridin-5-yl)dodecanamido)-2-(1-quinuclidinyl)quinoline  0   *Quinolines *Quinuclidines. Bioorg Med Chem Lett 2006 Oct 15;16(20):5270-4
N-(1-azabicyclo(2.2.2)oct-3-yl)furo(2,3-c)pyridine-5-carboxamide  0   *Quinuclidines *Bicyclo Compounds, Heterocyclic Receptors, Nicotinic. J Med Chem 2006 Jul 13;49(14):4425-36
3'-(3-methylbenzo(b)thiophen-5-yl)spiro(1-azabicyclo(2.2.2)octane-3,5'-oxazolidin)-2'-one  0   *Oxazoles *Quinuclidines Receptors, Nicotinic. J Med Chem 2006 Jul 13;49(14):4374-83
TX 2100  0   *Boron Compounds *Quinuclidines. Int J Hyperthermia 2006 Jun;22(4):287-99
2-quinuclidone  0   *Quinuclidines. Nature 2006 Jun 8;441(7094):699-700
quinuclidin-3-Ol  0   *Quinuclidines. Chem Biol Interact. 2005 Dec 15;157-158():420-1
(Z)-2-(3-methoxybenzylidene)-1-azabicyclo(2.2.2)octan-3-one  0   *Quinuclidines Guaiacol/*analogs & derivatives. Acta Crystallogr C 2005 Nov;61(Pt 11):o660-1
3'-(5-chlorothiophen-2-yl)spiro-1-azabicyclo(2.2.2)octane-3,5'-(1',3')-oxazolidin-2'-one  0   *Oxazoles *Quinuclidines Receptors, Nicotinic/agonists. J Med Chem 2005 Apr 7;48(7):2678-86
2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo(2.2.2)octan-3-one  0   *Quinuclidines Guaiacol/*analogs & derivatives. Acta Crystallogr C 2003 Nov;59(Pt 11):o647-9
3-((2-benzyl-6-(3-methoxypropyloxy)pyridin-3-yl)ethynyl)quinuclidin-3-ol  0   *Pyridines *Quinuclidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Antimicrob Agents Chemother 2004 Jul;48(7):2379-87
3-((2-benzyl-6-(3-hydroxy-4-methoxypyrrolidin-1-yl)pyridin-3-yl)ethynyl)quinuclidin-3-ol  0   *Pyridines *Quinuclidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Antimicrob Agents Chemother 2004 Jul;48(7):2379-87
penehyclidine  0   *Quinuclidines. Yao Xue Xue Bao 2002 Oct;37(10):802-6
(R)-N-(3-quinuclidinyl)-7-oxo-dihydrothieno(3,2b)pyridine-6-carboxamide hydrochloride  0   *Pyridines *Quinuclidines. Aliment Pharmacol Ther. 2003 Nov 15;18(10):1039-48
3-(2'-phenyl-2'-cyclopentyl-2'-hydroxyl-ethoxy)quinuclidine  0   *Quinuclidines. Life Sci 2003 Jul 11;73(8):1053-62
3-quinuclidinol  0   *Quinuclidines. J Mass Spectrom. 2002 Dec;37(12):1213-8
solifenacin succinate  0   *Quinuclidines *Tetrahydroisoquinolines.
Pharma Action Muscarinic Antagonists 		Gen Pharmacol 2000 Aug;35(2):71-5SOLIFENACIN SUCCINATE
bis(cinchoninium tetrachlorocuprate(II)) trihydrate  0   *Organometallic Compounds *Quinuclidines Copper. Inorg Chem 2001 Aug 27;40(18):4526-33
1,4-bis(3-((3-azabicyclo(2.2.2)octanyl)-1,2,5-thiadiazol-4-yloxy)-1-propyn-1-yl)benzene  0   *Quinuclidines *Thiadiazoles. J Pharmacol Exp Ther 2001 Sep;298(3):1260-8
NNC 11-1314  0   *Quinuclidines *Thiadiazoles. J Pharmacol Exp Ther 2001 Sep;298(3):1260-8
CS 932  0   *Isoxazoles *Quinuclidines Receptors, Muscarinic/agonists. Jpn J Pharmacol 2000 Nov;84(3):266-80
YM 53601  0   *Quinuclidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Br J Pharmacol 2000 Sep;131(1):63-70
N-(1-azabicyclo(2.2.2)oct-3-yl)-6--chloro-7-nitrobenzimidazole-4-carboxamide  0   *Benzimidazoles *Quinuclidines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):5020-8
N-(1-azabicyclo(2.2.2)oct-3-yl)--6-chlorobenzimidazole-4-carboxamide  0   *Benzimidazoles *Quinuclidines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):5020-8
N-(1-azabicyclo(2.2.2)oct-3-yl)benzimidazole-4-carboxamide  0   *Benzimidazoles *Quinuclidines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):5020-8
3-(4-methyl-5-isoxazolyl)methylene-1-azabicyclo(2.2.2)octane  0   *Isoxazoles *Quinuclidines Ligands. J Med Chem 1999 Dec 2;42(24):4970-80
ethyl(3-quinuclidinyl)acetate  0   *Quinuclidines Ligands. Life Sci 1998;63(24):PL329-36
2-(3-pyridinyl)-1-azabicyclo(2.2.2)octane  0   *Pyridines *Quinuclidines Cholinergic Agents. J Pharmacol Exp Ther 1998 Mar;284(3):886-94
5-BrQNT  0   *Glycolates *Quinuclidines. Recept Signal Transduct 1997;7(3):177-201
sabcomeline  0   *Imines *Quinuclidines. J Pharmacol Exp Ther 1997 Dec;283(3):1059-68
Ro 5-5172  76201-95-1   *Quinuclidines. J Pharm Biomed Anal 1997 Apr;15(7):965-71
2-chloro-3-(3-quinuclidylimino)-1-methylindole  0   *Quinuclidines. Drug Des Discov 1996 Oct;14(2):157-70
RS 56812  0   *Quinuclidines. Neuroreport 1996 Dec 20;8(1):49-54
revatropate  149926-91-0   *Quinuclidines. Life Sci 1997;60(13-14):1053-60
3-quinuclidinyl 4-fluoromethylbenzilate  168104-70-9   *Benzilates *Quinuclidines Fluorine Radioisotopes. Nucl Med Biol 1996 Oct;23(7):889-96
3-(4-(pyrid-4-yl)phenyl)-3-hydroxyquinuclidine  0   *Quinuclidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. J Med Chem 1996 Jul 19;39(15):2971-9
3-(biphenyl-4-yl)-3-hydroxyquinuclidine  0   *Quinuclidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Biochem Pharmacol 1996 Jun 14;51(11):1477-87
3-(biphenyl-4-yl)quinuclidine  0   *Quinuclidines Farnesyl-Diphosphate Farnesyltransferase/antagonists & inhibitors. Biochem Pharmacol 1996 Jun 14;51(11):1477-87
3-quinuclidinyl tropate  165260-55-9   *Quinuclidines. Farmaco 1995 May;50(5):303-9
quiditene  0   *Quinuclidines. Eksp Klin Farmakol 1994 Nov-Dec;57(6):36-8
NC 1006  0   *Aniline Compounds *Quinuclidines. Gen Pharmacol 1994 Oct;25(6):1149-56
NC 1005  0   *Aniline Compounds *Quinuclidines. Gen Pharmacol 1994 Oct;25(6):1149-56
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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