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Receptors, Cell Surface

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Definition: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.  GEN: prefer specifics; coord IM with specific endogenous substance (IM); for hormone receptors in general coord HORMONES (IM) + RECEPTORS, CELL SURFACE (IM) or RECEPTORS, CYTOPLASMIC AND NUCLEAR (IM), for receptors of specific hormones, coord specific ho   
Examples Antigens, CD36; Asialoglycoprotein Receptor; Autoreceptors; Cysteine Loop Ligand-Gated Ion Channel Receptors; Folate Receptors, GPI-Anchored; Neuropilins; Receptor Protein-Tyrosine Kinases; Receptors, Adipokine; Receptors, Autocrine Motility Factor; Receptors, Biogenic Amine; Receptors, Collagen; Receptors, Death Domain; Receptors, Eicosanoid; Receptors, G-Protein-Coupled; Receptors, Guanylate Cyclase-Coupled; Receptors, Immunologic; Receptors, Lipoprotein; Receptors, N-Acetylglucosamine; Receptors, Neurotransmitter; Receptors, Notch; Receptors, Odorant; Receptors, Peptide; Receptors, Pheromone; Receptors, Phospholipase A2; Receptors, Proteinase-Activated; Receptors, Purinergic; Receptors, Transferrin; Receptors, Urokinase Plasminogen Activator; Receptors, Virus; Receptors, Wnt 		Other names Receptors, Endogenous Substances; Hormone Receptors, Cell Surface; Cell Surface Receptors; Endogenous Substances Receptors; Cell Surface Hormone Receptors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DEspR protein, human  0   *Receptors, Cell Surface. Physiol Genomics. 2011 Nov 7;43(21):1219-25
Jamc protein, zebrafish  0   *Receptors, Cell Surface *Zebrafish Proteins Muscle Proteins. PLoS Biol. 2011 Dec;9(12):e1001216.
Jamb protein, zebrafish  0   *Receptors, Cell Surface *Zebrafish Proteins Muscle Proteins. PLoS Biol. 2011 Dec;9(12):e1001216.
Izh3 protein, S cerevisiae  0   *Receptors, Cell Surface *Saccharomyces cerevisiae Proteins. J Mol Evol. 2011 Oct;73(3-4):134-52.
Nogo receptor 2, mouse  0   *Receptors, Cell Surface GPI-Linked Proteins. EMBO J. 2003 Jul 1;22(13):3291-302.
TIM-3 protein, rat  0   *Receptors, Cell Surface Biological Markers. Nature. 2002 Jan 31;415(6871):536-41.
PLG-R(KT) protein, mouse  0   *Receptors, Cell Surface. J Biol Chem. 2011 Sep 23;286(38):33125-33.
TAS2R8 protein, human  0   *Receptors, Cell Surface. Biosci Biotechnol Biochem. 2011;75(6):1188-90
Odz2 protein, rat  0   *Nerve Tissue Proteins *Receptors, Cell Surface. Proc Natl Acad Sci U S A 2011 Jul 19;108(29):12113-8
PYL10 protein, Arabidopsis  0   *Receptors, Cell Surface *Arabidopsis Proteins. Mol Cell 2011 Jun 10;42(5):662-72
RUL1 protein, Arabidopsis  EC 2.7.-   *Protein Kinases *Arabidopsis Proteins Receptors, Cell Surface. PLoS Genet 2011 Feb;7(2):e1001312
MOL1 protein, Arabidopsis  EC 2.7.-   *Protein Kinases *Arabidopsis Proteins Receptors, Cell Surface. PLoS Genet 2011 Feb;7(2):e1001312
Nod-like receptor pyrin domain-containing protein 6, mouse  0   *Receptors, Cell Surface. Cell 2011 May 27;145(5):745-57
Celsr3 protein, human  0   *Receptors, Cell Surface *Cadherins. Adv Exp Med Biol. 2010;706():179-88
AFB4 protein, Arabidopsis  0   *Receptors, Cell Surface *Arabidopsis Proteins F-Box Proteins. Curr Biol 2011 Mar 22;21(6):520-5
PLXDC2 protein, human  0   *Receptors, Cell Surface Neoplasm Proteins Tumor Markers, Biological. Ophthalmology. 2011 Apr;118(4):642-8
PTCHD3 protein, human  0   *Receptors, Cell Surface. BMC Med Genet. 2011;12() (dup#2):45
elastin-laminin receptor, human  0   *Receptors, Cell Surface. J Dermatol Sci 2011 Jan;61(1):60-2
golden goal protein, Drosophila  0   *Eye Proteins *Receptors, Cell Surface. Nat Neurosci 2011 Mar;14(3):314-23
TAS2R39 protein, human  0   *Receptors, Cell Surface. Biochem Biophys Res Commun 2011 Feb 25;405(4):620-5
PlexinA4 protein, mouse  0   *Receptors, Cell Surface. Nature. 2011 Feb 10;470(7333):259-63
Unc5 protein, Drosophila  0   *Receptors, Cell Surface *Drosophila Proteins Muscle Proteins. Neuron 2001 Nov 20;32(4):605-17
CKAP4 protein, rat  0   *Receptors, Cell Surface. Am J Physiol Lung Cell Mol Physiol 2010 Dec;299(6):L794-807
Dip2a protein, mouse  0   *Receptors, Cell Surface. Am J Physiol Renal Physiol 2010 Dec;299(6):F1320-7
GPR110 protein, human  0   *Receptors, Cell Surface *Oncogene Proteins. BMC Cancer 2010;10:40
IGFBP-3R protein, human  0   *Receptors, Cell Surface. J Biol Chem 2010 Sep 24;285(39):30233-46
granulocyte receptor 1, mouse  0   *Receptors, Cell Surface. Am J Physiol Gastrointest Liver Physiol 2010 Aug;299(2):G391-9
RL-TGR protein, zebrafish  0   *Receptors, Cell Surface *Zebrafish Proteins. Proc Natl Acad Sci U S A 2010 Jul 6;107(27):12339-44
Gitr protein, zebrafish  0   *Receptors, Cell Surface *Zebrafish Proteins. Int J Dev Biol 2010;54(5):815-25
Mtl1 protein, S cerevisiae  0   *Receptors, Cell Surface *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1999 Jun;19(6):3969-76
CORYNE protein, Arabidopsis  EC 2.7.11.1   *Receptors, Cell Surface *Protein-Serine-Threonine Kinases. Plant Physiol 2010 Jan;152(1):166-76
C9orf46 protein, human  0   *Receptors, Cell Surface. Blood 2010 Feb 18;115(7):1319-30
neurexin 1 protein, rat  0   *Receptors, Cell Surface. Neuron 2009 Dec 24;64(6):799-806
Rim21 protein, S cerevisiae  0   *Receptors, Cell Surface *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2010 Feb;30(4):897-907
KREMEN-2 protein, rat  0   *Receptors, Cell Surface. J Am Soc Nephrol 2010 Jan;21(1):124-35
diuretic hormone 44 receptor 2, Drosophila  0   *Receptors, Cell Surface *Drosophila Proteins. J Exp Biol. 2009 Oct 1;212(19):3142-7
diuretic hormone 44 receptor 1, Drosophila  0   *Receptors, Cell Surface *Drosophila Proteins. J Exp Biol. 2009 Oct 1;212(19):3142-7
LRRC19 protein, mouse  0   *Receptors, Cell Surface. Biochem Biophys Res Commun 2009 Oct 23;388(3):543-8
LRRC19 protein, human  0   *Receptors, Cell Surface NF-kappa B/agonists. Biochem Biophys Res Commun 2009 Oct 23;388(3):543-8
Gr28b protein, Drosophila  0   *Receptors, Cell Surface. J Comp Neurol 2008 Feb 1;506(4):548-68
FIBCD1 protein, human  0   *Receptors, Cell Surface. J Immunol 2009 Sep 15;183(6):3800-9
folate receptor 4, mouse  0   *Receptors, Cell Surface. Immunity 2007 Jul;27(1):145-59
Nogo receptor, zebrafish  0   *Receptors, Cell Surface *Zebrafish Proteins. Mol Cell Neurosci. 2009 Apr;40(4):401-9
HERCULES1 protein, Arabidopsis  EC 2.7.1.37   *Protein Kinases *Arabidopsis Proteins Receptors, Cell Surface. Proc Natl Acad Sci U S A 2009 May 5;106(18):7648-53
PAQR10 protein, mouse  0   *Receptors, Cell Surface. Mol Med 2008 Nov-Dec;14(11-12):697-704
ErpC protein, Borrelia burgdorferi  0   *Bacterial Outer Membrane Proteins *Receptors, Cell Surface. Infect Immun 2009 Jan;77(1):300-6
ErpA protein, Borrelia burgdorferi  0   *Bacterial Outer Membrane Proteins *Receptors, Cell Surface. Infect Immun 2009 Jan;77(1):300-6
ErpP protein, Borrelia burgdorferi  0   *Bacterial Outer Membrane Proteins *Receptors, Cell Surface. Infect Immun 2009 Jan;77(1):300-6
LYVE-1 protein, rat  0   *Receptors, Cell Surface. Ann Anat 2008;190(4):329-38
UNC5B protein, human  0   *Receptors, Cell Surface. Proc Natl Acad Sci U S A 2008 Aug 26;105(34):12491-6
Gr32a protein, Drosophila  0   *Receptors, Cell Surface *Drosophila Proteins. Nat Neurosci 2008 Aug;11(8):874-6
lisch-like protein, mouse  0   *Receptors, Cell Surface. PLoS Genet 2008;4(7):e1000137
plexin B3 protein, mouse  0   *Nerve Tissue Proteins *Receptors, Cell Surface. Biochem Biophys Res Commun 2008 Oct 10;375(1):11-5
SCART2 protein, mouse  0   *Receptors, Cell Surface. J Immunol 2008 Aug 1;181(3):1710-6
SCART1 protein, mouse  0   *Receptors, Cell Surface. J Immunol 2008 Aug 1;181(3):1710-6
Or67d protein, Drosophila  0   *Receptors, Cell Surface *Drosophila Proteins. Cell 2008 Jun 27;133(7):1255-65
Fzd8 protein, human  0   *Receptors, Cell Surface. Int J Oncol 2001 May;18(5):991-6
UNC5H4 protein, human  0   *Receptors, Cell Surface. Biochem Biophys Res Commun 2008 Jun 13;370(4):594-8
GASSHO2 protein, Arabidopsis  EC 2.7.1.-   *Protein Kinases *Arabidopsis Proteins Receptors, Cell Surface. Plant J 2008 Apr;54(1):1-14
GASSHO1 protein, Arabidopsis  EC 2.7.1.-   *Protein Kinases *Arabidopsis Proteins Receptors, Cell Surface. Plant J 2008 Apr;54(1):30-42
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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