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Receptors, Opioid

More information in Books or onNLM PubMed
Definition: Cell membrane proteins that bind opioids and trigger intracellular changes which influence the behavior of cells. The endogenous ligands for opioid receptors in mammals include three families of peptides, the enkephalins, endorphins, and dynorphins. The receptor classes include mu, delta, and kappa receptors. Sigma receptors bind several psychoactive substances, including certain opioids, but their endogenous ligands are not known.  coord IM with specific opioid (IM); DF: RECEPT OPIOID   
Examples Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma 		Other names Receptors, Opiate; Receptors, Narcotic; Receptors, Enkephalin; Receptors, Endorphin; Opioid Receptors; Narcotic Receptors; Enkephalin Receptors; Endorphin Receptors; beta-Endorphin Receptors; beta Endorphin Receptor; Receptors, beta Endorphin; Receptor, beta-Endorphin; Receptor, Opioid; Receptor, Opiate; Receptor, Enkephalin; Receptor, Endorphin; beta-Endorphin Receptor; Receptors, beta-Endorphin; Receptors, Normorphine; Opioid Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl)-3,3-dimethylpentan-2-ol  0   Buprenorphine/*analogs & derivatives Ligands Receptors, Opioid. J Pharmacol Exp Ther 2011 Mar;336(3):952-61
tyrosyl-cyclo(penicillamine-glycyl-phenylalanyl-penicillamine)-prolyl-leucyl-tryptophyl-NH-(3',5'-(CF3)2-Bzl)  0   *Peptides, Cyclic Receptors, Opioid/agonists Receptors, Neurokinin-1/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5491-501
1-(1-cyclooctylmethyl-5-(1-hydroxy-1-methylethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1,3-dihydrobenzoimidazol-2-one  0   *Benzimidazoles *Cyclooctanes Receptors, Opioid/antagonists & inhibitors. Peptides 2010 Jun;31(6):1194-204
6'-guanidinonaltrindole  0   *Guanidines Naltrexone/*analogs & derivatives Receptors, Opioid/agonists. Proc Natl Acad Sci U S A 2005 Jun 21;102(25):9050-5
17-(2-methyl-2-propenyl)-6,7-dehydro-4,5-epoxy-3,14-dihydroxy-6,7-2,3-indolomorphinan  0   *Morphinans Receptors, Opioid/antagonists & inhibitors. J Med Chem 2001 Apr 26;44(9):1471-4
oprm1 protein, zebrafish  0   *Receptors, Opioid *Zebrafish Proteins. Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):1-6
prepronociceptin  0   *Protein Precursors *Receptors, Opioid. Neuroscience 1999;91(3):991-1007
mitragynine pseudoindoxyl  0   *Secologanin Tryptamine Alkaloids Mitragyna Receptors, Opioid/agonists. Gen Pharmacol 1999 Jul;33(1):73-81
pronociceptin  0   *Protein Precursors *Receptors, Opioid. Neuroreport 1999 Feb 25;10(3):541-6
N-phenethyl-9-methyl-5-(3-hydroxyphenyl)morphan  0   *Morphinans Receptors, Opioid/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4143-9
N-methyl-9-methyl-5-(3-hydroxyphenyl)morphan  0   *Morphinans Receptors, Opioid/antagonists & inhibitors. J Med Chem 1998 Oct 8;41(21):4143-9
nociceptin (1-13)-NH2, Phe(1)-psi(CH2-NH)-Gly(2)  0   *Peptide Fragments *Opioid Peptides Receptors, Opioid/antagonists & inhibitors Receptors, Opioid/agonists. Eur J Pharmacol 1998 May 15;349(1):R5-R6
17-(cyclopropylmethyl)-6,7-didehydro--13,14-dihydroxy-5'-(2-(2-pyridinyl)ethenyl)indolo(2',3'-6,7)morphinan  0   *Indoles *Morphinans Receptors, Opioid/antagonists & inhibitors Receptors, Opioid/agonists. J Med Chem 1998 Jul 16;41(15):2872-81
17-(cyclopropylmethyl)-6,7-didehydro-4,5-epoxy-13,14-dihydroxy-7'-phenoxyindolo(2',3'-6,7)morphinan  0   *Indoles *Morphinans Receptors, Opioid/agonists Receptors, Opioid/antagonists & inhibitors. J Med Chem 1998 Jul 16;41(15):2872-81
tyrosyl-cyclo(N-methyl)-alanyl-alanyl-2,3-diaminopropionic acid-glycyl-phenylalanyl-NH-ethyl  0   *Peptides, Cyclic Receptors, Opioid/agonists. J Med Chem 1998 Jul 2;41(14):2631-5
nociceptin, Tyr(1)  0   *Opioid Peptides Receptors, Opioid/agonists. Biochem Biophys Res Commun 1997 May 19;234(2):309-12
nociceptin receptor  0   *Receptors, Opioid. Mol Pharmacol 1996 Sep;50(3):447-50
nociceptin  0   *Opioid Peptides Receptors, Opioid/agonists Excitatory Amino Acids/agonists.
Pharma Action Vasodilator Agents 		Nature 1995 Oct 12;377(6549):476; Science 1995 Nov 3;270(5237):792-4
Hyp 8-1 protein, rat  0   *Receptors, Opioid. Brain Res Mol Brain Res 1994 Nov;27(1):37-44
G protein-coupled receptor C3  0   *Receptors, Opioid. J Neurochem 1995 Jan;64(1):34-40
XOR1 receptor  0   *Receptors, Opioid. FEBS Lett 1994 Jul 4;348(1):75-9
F8Famide receptor  0   *Receptors, Opioid. Peptides 1993 Jul-Aug;14(4):749-53
6-(3-phenylpropyl)oximino naltrexone  127227-11-6 Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, O-(3-phenylpropyl)oxime, (5alpha)  *Oximes Naltrexone/*analogs & derivatives Receptors, Opioid/drug effects. Pharmacol Biochem Behav 1993 Jan;44(1):45-50
6-(2-phenylethyl)oximino naltrexone  127227-10-5 Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, O-(2-phenylethyl)oxime, (5alpha)  *Oximes Naltrexone/*analogs & derivatives Receptors, Opioid/drug effects. Pharmacol Biochem Behav 1993 Jan;44(1):45-50
3,4-dihydro-1'-(3-methylbut-2-enyl)spiro(1H-indene-1,4'-piperidine)  137730-58-6   *Indenes *Piperidines Receptors, Opioid. J Med Chem 1992 May 29;35(11):2033-9
3-cyclohexyl-1,2,3,4,4a,5,6,10b-octahydrobenz(f)isoquinoline  140605-06-7   *Isoquinolines Receptors, Opioid. J Med Chem 1992 May 29;35(11):2025-33
HW 173  110270-70-7   *Quinolines Receptors, Opioid. Eur J Pharmacol 1991 Aug 29;201(2-3):199-202
1-(3-(4-fluorobenzoyl)propyl)-3-methyl-4-phenyl-4-propionoxypiperidine  130549-78-9   Alphaprodine/*analogs & derivatives Receptors, Opioid. J Med Chem 1991;34(1):194
KT 90  129200-07-3   *Morphine Derivatives Receptors, Opioid/drug effects. Gen Pharmacol 1990;21(4):541
KT 89  129224-33-5   *Morphine Derivatives Receptors, Opioid/drug effects. Gen Pharmacol 1990;21(4):541
zeta receptor  0   *Receptors, Opioid. J Natl Cancer Inst 1990;82(4):325
N-allyl-7-N,N-bis(beta-chloroethyl)amino-6,14-endoethenotetrahydronororipavine  123553-00-4   Thebaine/*analogs & derivatives Receptors, Opioid/drug effects. Sci China (B) 1989;32(3):335
7-(N,N-bis(2-chloroethyl)amino)-6,14-endoethenotetrahydrooripavine  94859-17-3   Thebaine/*analogs & derivatives Receptors, Opioid/drug effects. Chung Kuo I Hsueh Ko Hsueh Yuan Hsueh Pao 1987;9(2):118
morphiceptin, N-Me-Phe(3)  83397-56-2   *Endorphins Receptors, Opioid. Brain Res 1984;323(1):73
epsilon receptor  0   *Receptors, Opioid. Mol Pharmacol 1984;26(3):484
benzomorphan receptor  0   *Receptors, Opioid. J Pharmacol Exp Ther 1984;230(1):110
lambda opiate receptor  0   *Receptors, Opioid. Eur J Pharmacol 1984;101(1-2):161
14-(2-bromoacetamido)morphinone  87307-37-7   *Morphine Derivatives Receptors, Opioid/drug effects. J Med Chem 1983;26(12):1775
tifluadom  83386-35-0 3-Thiophenecarboxamide, N-((5-(2-fluorophenyl)-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-2-yl)methyl)  *Benzodiazepines Receptors, Opioid.
Pharma Action Diuretics 		Nature 1982;298(5876):759
naloxone receptor  0   *Receptors, Opioid. Brain Res 1982;3(4):637
methionine-enkephalin receptor  0   *Receptors, Opioid Enkephalin, Methionine. J Biol Chem 1982;25(3):1274
buprenorphine receptor  0   *Receptors, Opioid. Life Sci 1981;29(26):2699
apomorphine receptor  0   *Receptors, Opioid *Receptors, Dopamine D2 Apomorphine. Life Sci 1981;29(2):121
dynorphin receptor  0   *Receptors, Opioid. Nature 1981;291(5816):591

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