encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

Receptor, Epidermal Growth Factor

More information in Books or onNLM PubMed
Definition: A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.  DF: RECEPT EGF    Other names erbB-1 Proto-Oncogene Protein; Urogastrone Receptor; Transforming Growth Factor alpha Receptor; c-erbB-1 Protein; TGF-alpha Receptor; Receptors, Epidermal Growth Factor-Urogastrone; Receptor, Urogastrone; Receptor, Transforming-Growth Factor alpha; Receptor, TGF-alpha; Receptor, EGF; Epidermal Growth Factor Receptor Protein-Tyrosine ; Epidermal Growth Factor Receptor; EGF Receptor; erbB 1 Proto Oncogene Protein; c erbB 1 Protein; Receptors, Epidermal Growth Factor Urogastrone; Receptor, Transforming Growth Factor alpha; Receptor, TGF alpha; Proto-Oncogene Protein, erbB-1; Epidermal Growth Factor Receptor Protein Tyrosine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
XL647  0   *Quinazolines *Azabicyclo Compounds Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors Receptor, EphB4/antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2/antagonists & inhibitors. Clin Cancer Res. 2007 Jun 15;13(12):3713-23.
WZ4002  0   *Acrylamides *Pyrimidines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Lab Invest. 2012 Mar;92(3):371-83.
N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide  0   *Hydroxybutyrates *Bicyclo Compounds, Heterocyclic Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem. 2011 Dec 8;54(23):8030-50.
ZR 2003  0   *Nitrogen Mustard Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1135-8.
AST 1306  0   *Acrylamides *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. PLoS One 2011;6(7):e21487
EGFR tyrosine kinase inhibitor 324674  0   *Anilides *Pyrimidines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Biochem Biophys Res Commun 2011 Aug 12;411(4):751-6
(6,7-dimethoxyethoxy)quinolin-4-yl-(3-ethynylphenyl)amine  0   *Aminoquinolines *Aniline Compounds Receptor, Epidermal Growth Factor/antagonists & inhibitors. Cancer Biother Radiopharm 2010 Aug;25(4):479-85
4-(dimethylamino)-1-(4-(2-hydroxy-1-phenylethyl)amino-5,6,7,8-tetrahydropyrido(4',3'-4,5)thieno(2,3-d)pyrimidin-7-yl)-2-buten-1-one  0   *Heterocyclic Compounds, 3-Ring Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 2010 Oct 28;53(20):7316-26
1-(4-((2-hydroxy-1-phenylethyl)amino)-5,6,7,8-tetrahydropyrido(4',3'-4,5)thieno(2,3-d)pyrimidin-7-yl)-2-propen-1-one  0   *Heterocyclic Compounds, 3-Ring Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 2010 Oct 28;53(20):7316-26
1-acryloyl-N-(4-(3-chloro-2,4-difluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide  0   *Aniline Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6880-8
1-acryloyl-N-(4-(3-chloro-2-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide  0   *Aniline Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6880-8
(4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester  0   *Carbamates *Triazines Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 2009 Nov 12;52(21):6527-30
panitunumab  0   *Antibodies, Monoclonal Receptor, Epidermal Growth Factor. Int J Colorectal Dis. 2009 Oct;24(10):1247-8
EGFR protein, mouse  EC 2.7.10.1   *Receptor, Epidermal Growth Factor. Dermatol Online J. 2009;15(3):1
N-(3-bromophenyl)-7-methoxy-6-(3-(3-methoxypyrrolidin-1-yl)propoxy)quinazolin-4-amine  0   *Aniline Compounds *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Invest New Drugs 2009 Feb;27(1):1-11
F90 compound  0   *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Chin Med J (Engl) 2008 Sep 5;121(17):1702-6
MP 412  0   *Piperazines *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptor, erbB-2/antagonists & inhibitors. Cancer Sci 2007 Dec;98(12):1977-84
monoclonal antibody 806  0   *Antibodies, Monoclonal Receptor, Epidermal Growth Factor. Proc Natl Acad Sci U S A 2007 Mar 6;104(10):4071-6
FR18 compound  0   *Naphthoquinones Receptor, Epidermal Growth Factor/antagonists & inhibitors. Biochem Biophys Res Commun 2007 Mar 9;354(2):409-13
N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)-4-dimethylamino-2-butenamide  0   *Quinazolines Fluorine Radioisotopes Receptor, Epidermal Growth Factor/antagonists & inhibitors. Nucl Med Biol 2007 Jan;34(1):55-70
8-((3-bromophenyl)amino)-3-methyl-3H-imidazo(4,5-g)quinazoline  0   *Imidazoles *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 1996 Feb 16;39(4):918-28
EGFR protein, human  EC 2.7.10.1   *Receptor, Epidermal Growth Factor. Br J Cancer. 2006 Jun 5;94(11):1703-9
1-(2-chloroethyl)-1-nitroso-3-methyl-3-((4-(3-chlorophenyl)amino)quinazolin-6-yl)urea  0   Ethylnitrosourea/*analogs & derivatives Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 2006 Jun 15;49(12):3544-52
MDA-BF-1, human  0   *Receptor, Epidermal Growth Factor. J Pathol 2004 Jun;203(2):688-95
panitumumab  0 Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal ABX-EGF heavy chain), disulfide with human monoclonal ABX-EGF light chain, dimer  *Antibodies, Monoclonal Antineoplastic Agents Colonic Neoplasms Receptor, Epidermal Growth Factor. Lancet Oncol. 2005 May;6(5):279-86VECTIBIX
secErbB4-26-549  EC 2.7.1.112   *Peptide Fragments *Receptor, Epidermal Growth Factor. Oncol Res 2004;14(11-12):589-602
2-((4-(3-chloro-4-fluorophenylamino)quinazolin-6-ylamino)methyl)benzene-1,4-diol  0   *Hydroquinones *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Eur J Med Chem 2004 Dec;39(12):1001-11
2-((4-(3-bromophenylamino)quinazolin-6-ylamino)methyl)benzene-1,4-diol  0   *Hydroquinones *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Eur J Med Chem 2004 Dec;39(12):1001-11
6-(3-acetoxymethyl-3-methyltriazenyl)-4-(3'-bromophenylamino)quinazoline  0   *Quinazolines *Triazenes Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 2003 Dec 4;46(25):5546-51
AEE 788  0   *Purines Receptor, Epidermal Growth Factor/antagonists & inhibitors Receptors, Vascular Endothelial Growth Factor/antagonists & inhibitors. Cancer Res 2004 Jul 15;64(14):4931-41
Rhbdf1 protein, mouse  0   *Receptor, Epidermal Growth Factor.
Egfr protein, rat  0   *Receptor, Epidermal Growth Factor Receptor, Epidermal Growth Factor.
AGER protein, Anopheles gambiae  0   *Receptor, Epidermal Growth Factor *Insect Proteins. Insect Mol Biol 2001 Dec;10(6):619-28
N-(4-((3-bromophenyl)amino)--6-quinazolinyl)-4-(dimethylamino)-2-butenamide  0   *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 2001 Aug 16;44(17):2719-34
gefitinib  184475-35-2   *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Protein Kinase Inhibitors 		Drugs. 2000;60 Suppl 1:25-32; discussion 41-2IRESSA
N-(4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)acrylamide  0   *Acrylamides *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Cancer Res. 2000 Sep 1;60(17):4678-81
EKI 785  0   *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors. Nat Med 2000 Sep;6(9):1024-8
EKB 569  0   *Aminoquinolines *Aniline Compounds Receptor, Epidermal Growth Factor/antagonists & inhibitors. Nat Med 2000 Sep;6(9):1024-8
cetuximab  0   *Antibodies, Monoclonal Epidermal Growth Factor Receptor, Epidermal Growth Factor.
Pharma Action Antineoplastic Agents 		JAMA 2000 Jul 19;284(3):293-5ERBITUX
epidermal growth factor receptor VIII  0   *Receptor, Epidermal Growth Factor. J Biol Chem 2000 Jun 9;275(23):17358-63
PKI 166  0   *Pyrimidines *Pyrroles Receptor, Epidermal Growth Factor/antagonists & inhibitors. Cancer Res 2000 Jun 1;60(11):2926-35
erlotinib  0   *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors.
Pharma Action Protein Kinase Inhibitors 		J Pharmacol Exp Ther 1999 Nov;291(2):739-48ERLOTINIB HYDROCHLORIDE; TARCEVA
4,5-bis(4-fluoroanilino)phthalimide  0   *Phthalimides Receptor, Epidermal Growth Factor/antagonists & inhibitors. Clin Cancer Res 1995 Jul;1(7):813-21
naamidine A  110189-06-5   *Imidazoles Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 1998 Sep 24;41(20):3909-11
4-((3-bromophenyl)amino)-6-(methylamino)pyrimido(5,4-d)pyrimidine  0   *Pyrimidines Protein-Tyrosine Kinases/antagonists & inhibitors Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Med Chem 1997 Jun 6;40(12):1820-6
ELP protein, Arabidopsis  0   *Arabidopsis Proteins Receptor, Epidermal Growth Factor. Plant Physiol 1997 May;114(1):325-36
cochliobolic acid  0   *Furans *Polyenes Receptor, Epidermal Growth Factor/antagonists & inhibitors. J Nat Prod 1997 Jan;60(1):6-8
tyrphostin AG 1478  170449-18-0   *Quinazolines *Tyrphostins Receptor, Epidermal Growth Factor/antagonists & inhibitors Protein Tyrosine Phosphatases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Cancer Res 1996 Sep 1;56(17):3859-61
4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline  0   *Quinazolines Receptor, Epidermal Growth Factor/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors ; Intercalating Agents 		Science 1994 Aug 19;265(5175):1093-5
let-23 protein, C elegans  EC 2.7.1.112   *Receptor, Epidermal Growth Factor *Caenorhabditis elegans Proteins. EMBO J 1994 Jan 15;13(2):360-6
RHBDF1 protein, human  0   *Receptor, Epidermal Growth Factor. Mamm Genome 1993;4(6):314-23
receptor tyrosine-protein kinase erbB-4  EC 2.7.10.1   *Receptor, Epidermal Growth Factor. Proc Natl Acad Sci U S A 1993 Mar 1;90(5):1746-50
Egfr protein, Drosophila  EC 2.7.1.112   *Receptor, Epidermal Growth Factor *Receptors, Invertebrate Peptide *Drosophila Proteins. Oncogene 1990;5(10):1589
epidermal growth factor receptor-neu receptor  0   *Receptor, Epidermal Growth Factor *Receptor, erbB-2. Oncogene 1990;5(6):815
tripalmitoyl-S-glyceryl-cysteine-epidermal growth factor receptor(516-529)  98125-76-9   *Dipeptides *Receptor, Epidermal Growth Factor. Clin Exp Immunol 1989;78(3):499
epidermal growth factor receptor related protein, human  0   *Glycoproteins Epidermal Growth Factor Receptor, Epidermal Growth Factor. Science 1984;224(4646):294

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy