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Receptors, GABA-A

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Definition: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.      Other names Receptors, Muscimol; Receptors, GABA-Benzodiazepine; Receptors, Diazepam; Receptors, Benzodiazepine-GABA; Receptors, Benzodiazepine; GABA-A Receptors; Benzodiazepine-Gaba Receptors; epsilon Subunit, GABA A Receptor; delta Subunit, GABA A Receptor; Receptors, GABA Benzodiazepine; Receptors, GABA A; Receptors, Benzodiazepine GABA; Receptor, Muscimol; Receptor, GABA-Benzodiazepine; Receptor, GABA-A; Receptor, Diazepam; Receptor, Benzodiazepine-GABA; Receptor, Benzodiazepine; GABA Benzodiazepine Receptors; GABA Benzodiazepine Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-((2-(3-fluoropyridin-2-yl)-1H-imidazol-1-yl)methyl)-2-methyl-8-propyl-(1,2,4)triazolo(1,5-c)pyrimidine  0   *Pyrimidines *Triazoles Receptors, GABA-A GABA Agonists. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.
GABRQ protein, human  0   *Receptors, GABA-A Protein Subunits. Pharmacogenet Genomics 2011 Jul;21(7):436-9
4-oxo-4,5,6,7-tetrahydro-1H-indole-3-carboxylic acid (4-methylaminomethylphenyl)amide  0   *Anilides *Indoles Receptors, GABA-A. Xenobiotica 2010 Jun;40(6):400-14
bis(propyl)cognitin  0   Tacrine/*analogs & derivatives Receptors, GABA-A Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors. J Biol Chem 2010 Jun 25;285(26):19947-58
Gabrr3 protein, mouse  0   *Receptors, GABA-A.
GABRR3 protein, human  0   *Receptors, GABA-A.
Gabrr1 protein, mouse  0   *Receptors, GABA-A.
GABRR1 protein, human  0   *Receptors, GABA-A.
7-cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-3-ylmethoxy)-3-phenyl-1,2,4-triazolo(4,3-b)pyridazine  0   *Pyridazines *Triazoles Receptors, GABA-A/agonists. J Pharmacol Exp Ther 2010 Jan;332(1):4-16
Gabrg2 protein, rat  0   *Receptors, GABA-A.
Gabrg2 protein, mouse  0   *Receptors, GABA-A.
GABRG2 protein, human  0   *Receptors, GABA-A.
Gabre protein, rat  0   *Receptors, GABA-A.
Gabre protein, mouse  0   *Receptors, GABA-A.
Gabrb3 protein, rat  0   *Receptors, GABA-A.
GABRE protein, human  0   *Receptors, GABA-A.
GABRB3 protein, human  0   *Receptors, GABA-A.
Gabrb3 protein, mouse  0   *Receptors, GABA-A.
Gabrb1 protein, rat  0   *Receptors, GABA-A.
Gabrb1 protein, mouse  0   *Receptors, GABA-A.
GABRB1 protein, human  0   *Receptors, GABA-A.
Gabra4 protein, rat  0   *Receptors, GABA-A.
Gabra4 protein, mouse  0   *Receptors, GABA-A.
GABRA4 protein, human  0   *Receptors, GABA-A.
Gabra3 protein, rat  0   *Receptors, GABA-A.
Gabra3 protein, mouse  0   *Receptors, GABA-A.
GABRA3 protein, human  0   *Receptors, GABA-A.
Gabra1 protein, rat  0   *Receptors, GABA-A.
Gabra1 protein, mouse  0   *Receptors, GABA-A.
GABRA1 protein, human  0   *Receptors, GABA-A.
Gabra6 protein, rat  0   *Receptors, GABA-A.
Gabra6 protein, mouse  0   *Receptors, GABA-A.
GABRA6 protein, human  0   *Receptors, GABA-A.
lesogaberan  0   *Phosphinic Acids *Propylamines Receptors, GABA-A/agonists. IDrugs 2009 Sep;12(9):576-84
1-(4-aminobutanoyl)-4-(1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy)-7-nitroindoline  0   *Indoles *Phosphonic Acids Receptors, GABA-A/antagonists & inhibitors. J Neurosci Methods 2009 Jul 30;181(2):159-69
3'-(5-(1-hydroxy-1-methylethyl)benzoimidazol-1-yl)biphenyl-2-carbonitrile  0   *Benzimidazoles Receptors, GABA-A/agonists. J Pharmacol Exp Ther 2008 Dec;327(3):954-68
GABRG1 protein, Xenopus  0   *Receptors, GABA-A. Br J Pharmacol 2008 Oct;155(3):424-33
GABRG1 protein, human  0   *Receptors, GABA-A. Genomics 2008 Jan;91(1):61-9
Gabrr3 protein, rat  0   *Receptors, GABA-A. Biochem Biophys Acta 1996 Feb 7;1305(1-2):15-8
Gabrr1 protein, rat  0   *Receptors, GABA-A. Neuroreport 1996 Aug 12;7(12):2005-9
GABRG3 protein, human  0   *Receptors, GABA-A. Genomics 1995 Mar 20;26(2):258-64
GABRA5 protein, human  0   *Receptors, GABA-A. Hum Mol Genet 1992 Aug;1(5):348
Unc-49 protein, C elegans  0   *Receptors, GABA-A *Caenorhabditis elegans Proteins. Mol Pharmacol 2007 Nov;72(5):1322-9
Gabra2 protein, rat  0   *Receptors, GABA-A Protein Subunits. J Neurochem 2002 Sep;82(6):1512-23
GABRP protein, human  0   *Receptors, GABA-A. Int J Cancer 2006 Mar 15;118(6):1453-9
N-(p-methylbenzyl)-5-nitroindol-3-ylglyoxylamide  0   *Indoles Receptors, GABA-A/agonists. J Med Chem 2007 Apr 5;50(7):1627-34
N-(3-fluoro-4-(2-(propylamino)ethoxy)phenyl)-4,5,6,7-tetrahydro-4-oxo-1H-indole-3-carboxamide  0   *Indoles Receptors, GABA-A/agonists. Drug Metab Dispos 2005 Nov;33(11):1688-99
Gabra5 protein, rat  0   *Receptors, GABA-A. FEBS Lett 1990 Jan 29;260(2):261-5
N,N-dimethyl-(2-(4-methylphenyl)-5-methylpyrazolo(1,5-a)pyrimidin-3-yl)acetamide  0   *Pyrazoles *Pyrimidines Receptors, GABA-A/agonists. J Med Chem 2005 Oct 20;48(21):6756-60
3-amino-2-fluoropropylsulfinic acid  0   *Sulfinic Acids Receptors, GABA-A/agonists. Br J Pharmacol 2005 Sep;146(1):89-97
1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydroimidazol-2-one  0   *Imidazoles *Piperidines Receptors, GABA-A/agonists. J Pharmacol Exp Ther 2005 Aug;314(2):717-24
Gabrb2 protein, rat  0   *Receptors, GABA-A. J Neurosci 2004 Dec 15;24(50):11226-35
9-chloro-2-phenyl-(1,2,3)triazolo(1,2-a)(1,2,4)benzotriazin-1,5(6H)-dione  0   *Triazines *Triazoles Receptors, GABA-A/antagonists & inhibitors Receptors, GABA-A/agonists. J Med Chem 2005 Apr 21;48(8):2936-43
Gabra5 protein, mouse  0   *Receptors, GABA-A Protein Subunits. Proc Natl Acad Sci U S A 2002 Jun 25;99(13):8980-5
GABRB2 protein, human  0   *Receptors, GABA-A. Mol Pharmacol 1993 Dec;44(6):1211-8
2-methoxy-3,8,9-trihydroxy coumestan  0   *Isoflavones Receptors, GABA-A/agonists. Eur J Pharmacol. 2004 Jul 14;495(2-3):87-96
Gabra2 protein, mouse  0   *Receptors, GABA-A. J Neurosci 2004 Jul 14;24(28):6343-51
Gabrr2 protein, mouse  0   *Receptors, GABA-A.
Gabrr2 protein, rat  0   *Receptors, GABA-A.
F17A22.16 protein, Arabidopsis  0   *Arabidopsis Proteins Receptors, GABA-A. Plant Cell Physiol 2004 Jun;45(6):723-33
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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