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Receptors, LHRH

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Definition: Receptors with a 6-kDa protein on the surfaces of cells that secrete LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE, usually in the adenohypophysis. LUTEINIZING HORMONE-RELEASING HORMONE binds to these receptors, is endocytosed with the receptor and, in the cell, triggers the release of LUTEINIZING HORMONE or FOLLICLE STIMULATING HORMONE by the cell. These receptors are also found in rat gonads. INHIBINS prevent the binding of GnRH to its receptors.  DF: RECEPT LHRH   
See Also Gonadotropin-Releasing Hormone; Inhibins 		Other names Receptors, Luliberin; Receptors, Gonadorelin; Receptors, Gonadoliberin; Receptors, GnRH; Luliberin Receptors; LHRH Receptors; LHFSHRH Receptors; Gonadotropin Releasing-Hormone Receptors; Gonadorelin Receptors; Gonadoliberin Receptors; GnRH Receptors; Releasing-Hormone Receptors, Gonadotropin; Receptors, Gonadotropin Releasing Hormone; Receptor, Gonadotropin-Releasing Hormone; Receptor, Gonadorelin; Receptor, GnRH; Luteinizing Hormone Releasing Hormone Receptor; Hormone Receptor, Gonadotropin-Releasing; Gonadotropin Releasing Hormone Receptors; Gonadotropin Releasing Hormone Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxypyridazin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(2,3-d)pyrimidin-6-yl)phenyl)-3-methoxyurea  0   *Phenylurea Compounds *Pyrimidinones Receptors, LHRH/antagonists & inhibitors. J Med Chem 2011 Jul 28;54(14):4998-5012
6-((4-(2-(4-tert-Butylphenyl)-1H-benzimidazol-4-yl)piperazin-1-yl)methyl)quinoxaline  0   *Benzimidazoles *Quinoxalines Receptors, LHRH/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):2148-52
3-(N-benzyl-N-methylaminomethyl)-7-(2,6-difluorobenzyl)-4,7-dihydro-2-(4-(1-hydroxy-1-cyclopropanecarboxamido)phenyl)-5-isobutyryl-4-oxothieno(2,3-b)pyridine  0   *Pyridones *Thiophenes Receptors, LHRH/antagonists & inhibitors. J Med Chem 2006 Jun 29;49(13):3809-25
N-(4,6-dimethoxy-2-((3-morpholin-4-ylpropyl)amino)pyrimidin-5-yl)-5-(3,3,6-trimethyl-2,3-dihydro-1H-inden-5-yloxy)-2-furamide  0   *Morpholines *Pyrimidines Receptors, LHRH/antagonists & inhibitors. J Med Chem 2006 Jun 1;49(11):3362-7
3-(2-amino-2-phenylethyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methylpyrimidin-2,4-dione  0   Thymine/*analogs & derivatives Receptors, LHRH/antagonists & inhibitors. J Med Chem 2005 Feb 24;48(4):1169-78
GNRHR protein, human  0   *Receptors, LHRH. J Clin Endocrinol Metab 2004 Apr;89(4):1823-32
5-(N-benzyl-N-methylaminomethyl)-1--(2,6-difluorobenzyl)-6-(4-(3-methoxyureido)phenyl)-3-phenylthieno(2,3-d)pyrimidine-2,4(1H,3H)-dione  0   *Phenylurea Compounds *Pyrimidinones Receptors, LHRH/antagonists & inhibitors. J Med Chem 2003 Jan 2;46(1):113-24
IN3 compound  0   *Indoles *Pyridines *Bicyclo Compounds, Heterocyclic Receptors, LHRH/antagonists & inhibitors. J Clin Endocrinol Metab 2002 Jul;87(7):3255-62
(lysine(6)(1,3,8-trihydroxy-6-carboxyanthraquinone))GnRH  0   Gonadotropin-Releasing Hormone/*analogs & derivatives Receptors, LHRH/agonists. J Med Chem 2001 Oct 25;44(22):3645-52
GnRH receptor 3  0   *Receptors, LHRH. Endocrinology 2001 Sep;142(9):4015-25
GNRHR2 protein, human  0   *Receptors, LHRH. Biochem Biophys Res Commun 2001 Apr 13;282(4):1012-8
avorelin  0   Proline/*analogs & derivatives Oligopeptides Receptors, LHRH. J Urol 1999 Dec;162(6):2019-23
T 98475  0   *Pyridones *Thiophenes Receptors, LHRH/antagonists & inhibitors. J Med Chem 1998 Oct 22;41(22):4190-5
buserelin receptor  0   *Receptors, LHRH. Breast Cancer Res Treat 1993;25(1):37-46

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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