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Receptors, Muscarinic

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Definition: One of the two major classes of cholinergic receptors. Muscarinic receptors were originally defined by their preference for MUSCARINE over NICOTINE. There are several subtypes (usually M1, M2, M3....) that are characterized by their cellular actions, pharmacology, and molecular biology.  GEN or unspecified; prefer specifics   
Examples Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptor, Muscarinic M4; Receptor, Muscarinic M5 		Other names Muscarinic Receptors; Muscarinic Acetylcholine Receptors; Receptors, Muscarinic Acetylcholine; Receptor, Muscarinic Acetylcholine; Receptor, Muscarinic; Acetylcholine Receptors, Muscarinic; Acetylcholine Receptor, Muscarinic; Muscarinic Receptor; Muscarinic Acetylcholine Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GAR-3 protein, C elegans  0   *Receptors, Muscarinic *Caenorhabditis elegans Proteins. Biochem Biophys Res Commun 2003 Sep 5;308(4):961-5
8-benzyloxymethyl-3-ethoxycarbonyl-4-hydroxy-1-azabicyclo(3.3.1)non-3-ene  0   *Bicyclo Compounds, Heterocyclic Receptors, Muscarinic/antagonists & inhibitors. J Med Chem 2003 May 22;46(11):2216-26
M(2trunk) M(2tail) receptor  0   *Peptide Fragments *Receptors, Muscarinic. J Pharmacol Exp Ther 2003 May;305(2):786-95
6-(ethyl-(2-methoxybenzyl)amino)hexanoic acid (8-((6-(ethyl-(2-methoxybenzyl)amino)hexanoyl)methylamino)octyl)methylamide  0   *Amides *Anisoles Receptors, Muscarinic/antagonists & inhibitors. J Med Chem 2003 Mar 13;46(6):954-66
caproctamine  0   *Amides *Anisoles Receptors, Muscarinic/antagonists & inhibitors. J Med Chem 1998 Oct 22;41(22):4186-9
diisopropyl(2-(3-(1-pyridin-2-ylethyl)-1H-inden-2-yl)ethyl)amine  0   *Indenes Receptors, Muscarinic/antagonists & inhibitors. J Med Chem 2003 Feb 27;46(5):856-67
6-(4-butylthio-1,2,5-thiadiazol-3-yl)-1-azabicyclo(3.2.1)octane  0   *Tropanes Receptors, Muscarinic/agonists. J Pharmacol Exp Ther 2002 Oct;303(1):99-103
lithocholylcholine  0   Lithocholic Acid/*analogs & derivatives Receptors, Muscarinic/antagonists & inhibitors. J Pharmacol Exp Ther 2002 Oct;303(1):29-35
1-((4-methoxyphenyl)sulfonylphenyl)-1-(1-(1-(4-fluoro-1-naphthylcarbonyl)morpholin-4-yl)morpholin-4-yl)dioxole  0   *Dioxoles *Sulfones Receptors, Muscarinic/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2311-4
1-((4-methoxyphenyl)sulfonylphenyl)-1(1-(1-(1-naphthylcarbonyl)morpholin-4-yl)morpholin-4-yl)dioxole  0   *Dioxoles *Sulfones Receptors, Muscarinic/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2311-4
1-((3,4-methylenedioxyphenyl)sulfonylphenyl)-1-(1-(1-(n-propylsulfonyl)morpholin-4-yl)morpholin-4-yl)dioxole  0   *Dioxoles *Sulfones Receptors, Muscarinic/antagonists & inhibitors. Bioorg Med Chem Lett 2001 Sep 3;11(17):2311-4
CS 932  0   *Isoxazoles *Quinuclidines Receptors, Muscarinic/agonists. Jpn J Pharmacol 2000 Nov;84(3):266-80
CHRM1 protein, human  0   *Receptors, Muscarinic. J Biol Chem 1994 Mar 4;269(9):6651-5
5-((4-(4-(diisobutylamino)butyl)-1-phenyl)acetyl)-10,11-dihydro-5H-dibenzo(b,e)(1,4)diazepin-11-one  156586-94-6   *Dibenzazepines Receptors, Muscarinic. Life Sci 1993;53(23):1743-51
imperialone  23521-53-1   *Cevanes Receptors, Muscarinic/drug effects. Eksp Klin Farmakol 1993 Jul-Aug;56(4):14-7
muscarinic receptor kinase  EC 2.7.-   *Receptor Protein-Tyrosine Kinases Receptors, Muscarinic. J Biol Chem 1993 Apr 15;268(11):7753-8
talsaclidine fumarate  147025-54-5 1-Azabicyclo(2.2.2)octane, 3-(2-propynyloxy)-, (R)-, (E)-2-butenedioate (1:1)  *Quinuclidines Receptors, Muscarinic. Life Sci 1993;52(5-6):473-80
Lu 26-046  143756-51-8 Isothiazolo(4,5-c)pyridine, 4,5,6,7-tetrahydro-7-methyl-3-(2-propynyloxy)-, (-)  *Pyridines *Thiazoles Receptors, Muscarinic. Eur J Pharmacol 1992 Jul 21;218(1):159-69
3-methoxy-4,5,6,7-tetrahydroisoxazolo(4,5-c)pyridine  95579-17-2   *Isoxazoles *Pyridines Receptors, Muscarinic. Eur J Pharmacol 1992 Jul 21;218(1):159-69
3-(3-amino-1,2,4-oxadiazole-5-yl)-quinuclidine  114724-42-4 1,2,4-Oxadiazol-3-amine, 5-(1-azabicyclo(2.2.2)oct-5-yl)  *Oxadiazoles *Quinuclidines Receptors, Muscarinic. Naunyn Schmiedebergs Arch Pharmacol 1992 Apr;345(4):375-81
L 670548  121564-89-4 1-Azabicyclo(2.2.1)heptane, 3-(3-methyl-1,2,4-oxadiazol-5-yl)-, exo  *Oxadiazoles *Bicyclo Compounds, Heterocyclic Receptors, Muscarinic. J Biol Chem 1991;266(8):5004
azaprophen  107010-27-5   *Phenylpropionates *Tropanes Receptors, Muscarinic/drug effects. J Med Chem 1987;30(5):805
N-methylscopolamine receptor  0   *Receptors, Muscarinic. J Biochem Biophys Methods 1986;13(2):85
pirenzepine receptor  0   *Receptors, Muscarinic. Br J Pharmacol 1985;85(3):697
quinuclidinyl benzilate receptor  0   *Receptors, Muscarinic Quinuclidinyl Benzilate. J Neurochem 1981;36(2):454

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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