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Receptors, Serotonin

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Definition: Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.  GEN; prefer specifics; DF: RECEPT SEROTONIN   
Examples Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4 		Other names Tryptamine Receptors; Serotonin Receptors; Receptors, Tryptamine; 5-Hydroxytryptamine Receptors; 5-HT Receptors; Receptors, 5 Hydroxytryptamine; Receptors, 5 HT; 5 Hydroxytryptamine Receptors; 5 HT Receptors; Receptors, 5-Hydroxytryptamine; Receptors, 5-HT
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole  0   *Indazoles *Sulfones Receptors, Serotonin. J Med Chem 2010 Nov 11;53(21):7639-46
5-(dimethylamino)-N-(3-(4-(4-(((5-(dimethylamino)-1-naphthyl)sulfonyl)amino)butyl)piperazin-1-yl)-4-methoxyphenyl)naphthalene-1-sulfonamide  0   *Piperazines *Sulfonamides Ligands Receptors, Serotonin. J Med Chem 2010 Oct 14;53(19):7095-106
N-(6-(4-(5-(((5-chloro-3-methyl-1-benzothien-2-yl)sulfonyl)amino)-2-methoxyphenyl)piperazin-1-yl)hexyl)-5-(-2-oxohexahydro-1H-thieno(3,4-d)imidazol-4-yl)pentanamide  0   *Piperazines Biotin/*analogs & derivatives Ligands Receptors, Serotonin. J Med Chem 2010 Oct 14;53(19):7095-106
9,10-methylenedioxy-5,6-fadyenolide  0   4-Butyrolactone/*analogs & derivatives Receptors, Serotonin. J Ethnopharmacol 2010 May 27;129(2):220-6
N-methyl-(3-phenylsulfonyl)-7,8-dihydro-6H-cyclopenta(e)pyrazolo(1,5-a)pyrimidin-2-amine  0   *Pyrazoles *Pyrimidines Receptors, Serotonin. J Med Chem 2010 Jul 22;53(14):5186-96
N(1)-(6-chloroimidazo(2,1-b)(1,3)thiazole-5-sulfonyl)tryptamine  0   *Thiazoles *Tryptamines Receptors, Serotonin. J Med Chem 2007 Nov 15;50(23):5535-8
5-HT(7) receptor, rat  0   *Receptors, Serotonin. Bioorg Med Chem 2007 Aug 1;15(15):5316-21
4-(2-methylthiophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide  0   *Piperazines *Tetrahydronaphthalenes Receptors, Serotonin/agonists. J Med Chem 2004 Dec 16;47(26):6616-24
3-(benzenesulfonyl)-2-(methylsulfanyl)pyrido(1,2-a)pyrimidin-4-ylidenamine  0   *Pyrimidines *Sulfones Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2003 Nov 6;46(23):4834-7
2-(4-((6-amino-1,3-dioxo-1H-benzo(de)isoquinolin-2(3H)-yl)methyl)piperidin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate  0   *Aminobenzoic Acids *Isoquinolines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2003 Jun 19;46(13):2606-20
N-(5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl)-4-morpholinobenzamide  0   *Benzamides *Morpholines Receptors, Serotonin/antagonists & inhibitors. J Pharmacol Exp Ther 2003 Mar;304(3):1072-84
5-((N-propylpiperidin-4-yl)methoxy)-1,2,3,4-tetrahydrobenzo(h)(1,6)naphthyridine  0   *Naphthyridines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2003 Jan 2;46(1):138-47
LY 393558  0   *Cyclic S-Oxides *Thiadiazines Receptors, Serotonin/antagonists & inhibitors. Eur J Pharmacol 2001 Nov 30;432(1):9-17
1-(4-fluorophenyl)-2-(4-(phenylsulfonyl)-1-piperidinyl)ethanone  0   *Piperidines *Sulfones Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2002 Jan 17;45(2):492-503
4-((1-(2-(2,4-difluorophenyl)ethyl)-4-piperidinyl)sulfonyl)benzamide  0   *Benzamides *Sulfones Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2002 Jan 17;45(2):492-503
4-((1-(2-(2,4-difluorophenyl)ethyl)-4-piperidinyl)sulfonyl)benzonitrile  0   *Nitriles *Sulfones Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2002 Jan 17;45(2):492-503
N-(4-(3-methoxyphenyl)cyclohexyl)-2-(2-pyridyloxy)ethylamine  0   *Ethylamines *Pyridines Ligands Receptors, Serotonin/agonists. J Med Chem 2001 Dec 6;44(25):4431-42
4-(4-(3-methoxyphenyl)cyclohexyl)-1-(2-pyridinyl)piperazine  0   *Piperazines *Pyridines Ligands Receptors, Serotonin/agonists. J Med Chem 2001 Dec 6;44(25):4431-42
REC 15-3079  0   *Piperazines Receptors, Serotonin/antagonists & inhibitors. J Pharmacol Exp Ther 2001 Dec;299(3):1027-37
3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide  0   *Benzopyrans Receptors, Serotonin/agonists. J Pharmacol Exp Ther 2001 Dec;299(3):883-93
N-(3-(2-dimethylaminoethyl)-2-methyl-1H-indol-5-yl)-4-fluorobenzamide  0   *Benzamides *Indoles Receptors, Serotonin/agonists. J Med Chem 2001 Nov 22;44(24):4031-4
LY 367265  0   *Thiadiazoles Cyclic S-Oxides Receptors, Serotonin/antagonists & inhibitors. Eur J Pharmacol 2000 Oct 27;407(1-2):39-46
SL 88.0338  0   *Isoquinolines *Piperidines Receptors, Serotonin/antagonists & inhibitors. Neuropharmacology 2000 Jul 24;39(10):1848-57
MM 77  0   *Piperazines *Succinimides Receptors, Serotonin/antagonists & inhibitors. Neuropharmacology 2000 Jul 24;39(10):1848-57
LY 426965  0   *Piperidines Receptors, Serotonin/antagonists & inhibitors. J Pharmacol Exp Ther 2000 Aug;294(2):688-700
2-ethyl-5-methoxy-N,N-dimethyltryptamine  0   *Methoxydimethyltryptamines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 2000 Mar 9;43(5):1011-8
N-(1-azabicyclo(2.2.2)oct-3-yl)-6--chloro-7-nitrobenzimidazole-4-carboxamide  0   *Benzimidazoles *Quinuclidines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):5020-8
N-(1-azabicyclo(2.2.2)oct-3-yl)--6-chlorobenzimidazole-4-carboxamide  0   *Benzimidazoles *Quinuclidines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):5020-8
N-(1-azabicyclo(2.2.2)oct-3-yl)benzimidazole-4-carboxamide  0   *Benzimidazoles *Quinuclidines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):5020-8
L 772405  0   *Indoles *Triazoles Receptors, Serotonin/agonists. J Med Chem 1999 Dec 2;42(24):4981-5001
4-(3-(1-benzotriazolyl)cyclohexyl)-1-(2-methoxyphenyl)piperazine  0   *Piperazines *Triazoles Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):4952-60
1-(2-methoxyphenyl)-4-(4--(2-phthalimido)cyclohexyl)piperazine  0   *Phthalimides *Piperazines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Dec 2;42(24):4952-60
RS 127445  199864-87-4   *Pyrimidines Receptors, Serotonin/antagonists & inhibitors. Br J Pharmacol 1999 Jul;127(5):1075-82
2-(3,5-dimethylpiperidino)ethyl 4-amino-5-chloro-2-methoxybenzoate  0   *Aminobenzoic Acids *Piperidines Receptors, Serotonin/antagonists & inhibitors. Br J Pharmacol 1998 Oct;125(4):595-7
N-methyl-5-tert-butyltryptamine  0   *Tryptamines Receptors, Serotonin/agonists. J Med Chem 1999 Feb 11;42(3):526-31
1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine  0   *Indoles *Piperazines Receptors, Serotonin/agonists. J Med Chem 1999 Feb 25;42(4):691-705
3-(3-(N-(alpha-methylbenzyl)aminomethyl)pyrrolidiny)-5-((2-oxooxazolidinyl)methyl)indole  0   *Indoles *Oxazoles Receptors, Serotonin/agonists. J Med Chem 1999 Feb 25;42(4):677-90
3-(3-(N-benzylaminomethyl)pyrrolidinyl)-5-((2-oxooxazolidin-4-yl)methyl)indole  0   *Indoles *Oxazoles Receptors, Serotonin/agonists. J Med Chem 1999 Feb 25;42(4):677-90
2a-(4-phenyl-1,2,3,6-tetrahydropyridyl)cyclohex(a-3,4)indole-2-one  0   *Indoles *Pyridines Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1999 Feb 25;42(4):533-5
(3,4-dichlorophenyl)(4-((6-azetidinopyridin-2-ylmethylamino)methyl)piperidin-1-yl)methanone  0   *Azetidines *Pyridines Receptors, Serotonin/agonists. J Med Chem 1998 Dec 3;41(25):5070-83
(3,4-dichlorophenyl)(4-((6-oxazol-5-ylpyridin-2-ylmethylamino)methyl)piperidin-1-yl)methanone  0   *Oxazoles *Pyridines Receptors, Serotonin/agonists. J Med Chem 1998 Dec 3;41(25):5070-83
F 11440  0   *Pyrimidines *Triazines Receptors, Serotonin/agonists. J Pharmacol Exp Ther 1998 Oct;287(1):266-83
serotonin 1C receptor  0   *Receptors, Serotonin. Dev Growth Differ 1998 Apr;40(2):231-41
PD 158771  0   *Piperazines *Pyrimidines Receptors, Dopamine/agonists Receptors, Serotonin/agonists. J Med Chem 1998 Feb 26;41(5):760-71
6-(4-methyl-1-piperazinyl)--7,8,9,10-tetrahydro-8,10-ethanophenanthridine  0   *Phenanthridines *Piperazines Receptors, Serotonin/agonists. J Med Chem 1998 Feb 26;41(5):728-41
6-(4-methyl-1-piperazinyl)-7,8,9,10-tetrahydrophenanthridine  0   *Phenanthridines *Piperazines Receptors, Serotonin/agonists. J Med Chem 1998 Feb 26;41(5):728-41
SB 258719  0   *Piperidines *Sulfonamides Receptors, Serotonin/antagonists & inhibitors. J Med Chem 1998 Feb 26;41(5):655-7
N-(1-(2-nitrophenyl)ethoxycarbonyl)-D-AP5  0   Receptors, Serotonin. J Physiol 1997 Oct;504(2):379-85
serotonin receptor-like planarian receptor 1, Dugesia japonica  0   *Receptors, Serotonin. Gene 1997 Aug 11;195(1):55-61
CP 2289  0   *Benzoxazoles *Piperazines Receptors, Serotonin/agonists. Biol Pharm Bull 1997 Jul;20(7):752-5
LY 306258  0   *Carbazoles Receptors, Serotonin/agonists. Neuroreport 1997 Jul 7;8(9-10):2237-40
LY 302148  182564-47-2   *Indoles *Pyrazoles Receptors, Serotonin/agonists. Neuroreport 1997 Jul 7;8(9-10):2237-40
4-fluoro-N-(3-(1-methyl-4-piperidinyl)-1H-indol-5-yl)benzamide  0   *Benzamides *Indoles Receptors, Serotonin/agonists. Neuroreport 1997 Jul 7;8(9-10):2237-40
RS 67333  160845-95-4   *Aniline Compounds *Piperidines Receptors, Serotonin. Neuropharmacology 1997 Apr-May;36(4-5):689-96
RS 67532  0   *Aniline Compounds *Piperidines Receptors, Serotonin/agonists. Neuropharmacology 1997 Apr-May;36(4-5):689-96
RS 57639  0   *Aminobenzoic Acids *Piperidines Receptors, Serotonin/agonists. Neuropharmacology 1997 Apr-May;36(4-5):671-9
RS 102221  0   *Spiro Compounds *Sulfonamides Receptors, Serotonin/antagonists & inhibitors. Neuropharmacology 1997 Apr-May;36(4-5):621-9
SDZ 219-964  180616-21-1   Organic Chemicals Receptors, Serotonin/agonists Serotonin Receptor Agonists. Psychopharmacology (Berl) 1996 Jun;125(3):231-7
serotonin 7 receptor  0   *Receptors, Serotonin. Histochem J 1996 Nov;28(11):747-58
serotonin 1F receptor  0   *Receptors, Serotonin. Cephalalgia 1996 Aug;16(5):287-8
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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