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Retinaldehyde

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Definition: A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.  /biosyn /physiol permitted    Other names Vitamin A Aldehyde; Retinene; Retinal; Axerophthal; Aldehyde, Vitamin A; 11 cis Retinal; 11-cis-Retinal
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
retinal dimer ethanolamine  0   Retinaldehyde/*analogs & derivatives. Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19273-8
retinal dimer phosphatidylethanolamine  0   *Phosphatidylethanolamines Retinaldehyde/*analogs & derivatives. Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19273-8
retinal dimer  0   Retinaldehyde/*analogs & derivatives. Proc Natl Acad Sci U S A 2007 Dec 4;104(49):19273-8
7-methylretinal  0   Retinaldehyde/*analogs & derivatives. Vision Res 2006 Dec;46(27):4472-81
8-methylretinal  0   Retinaldehyde/*analogs & derivatives. Vision Res 2006 Dec;46(27):4472-81
5-demethyl-8-methylretinal  0   Retinaldehyde/*analogs & derivatives. Chemistry 2003 Dec 5;9(23):5821-31
diacneal  0   *Glycolates *Retinaldehyde Drug Combinations. Dermatology 2005;210 Suppl 1:2-5
11-mesitylretinal  0   Retinaldehyde/*analogs & derivatives. J Am Chem Soc 2001 Oct 17;123(41):10024-9
5-demethylretinal  0   Retinaldehyde/*analogs & derivatives. J Am Chem Soc 2001 Oct 17;123(41):10024-9
13-demethylretinal  0   Retinaldehyde/*analogs & derivatives. J Gen Physiol 2000 Aug;116(2):283-97
4-(2-((1,3,3-trimethylcyclohexen-2-yl)ethenyl)propylidene)-2,3-methylenecyclohept-1-ylmethylenemethanal  0   *Bicyclo Compounds Retinaldehyde/*analogs & derivatives. Org Lett 1999 Jul 15;1(1):51-4
3,7-dimethyl-9-(1-pyryl)-2,4,6,8-nonatetraenal  0   Retinaldehyde/*analogs & derivatives. Photochem Photobiol 1999 Dec;70(6):949-56
3-methyl-5-(1-pyryl)-2,4-pentadienal  0   Retinaldehyde/*analogs & derivatives. Photochem Photobiol 1999 Dec;70(6):949-56
9,13-demethylretinal  0   Retinaldehyde/*analogs & derivatives. Membr Cell Biol 1998;12(1):121-3
9-demethylretinal  0   Retinaldehyde/*analogs & derivatives. Biochemistry 1998 Jan 13;37(2):538-45
1O-methyl-13-demethylretinal  0   Retinaldehyde/*analogs & derivatives. Photochem Photobiol 1997 Jan;65(1):181-6
4-oxoretinaldehyde  33532-44-4   Retinaldehyde/*analogs & derivatives. Proc Natl Acad Sci U S A 1996 May 14;93(10):4873-8
8,18-propanoretinal  0   Retinaldehyde/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1995 Aug;43(8):1419-21
8,18-methanoretinal  0   Retinaldehyde/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1995 Aug;43(8):1419-21
4-bromoretinal  0   Retinaldehyde/*analogs & derivatives. Biochemistry 1994 Sep 27;33(38):11624-30
9-(4'-azido-2',3',5',6'-tetrafluorophenyl)-3,7-dimethyl-2,4,6,8-nonatetraenal  158632-36-1   Retinaldehyde/*analogs & derivatives. Photochem Photobiol 1994 Jul;60(1):64-8
9-desmethylretinal  0   Retinaldehyde/*analogs & derivatives. Vis Neurosci 1994 Jan-Feb;11(1):91-8
retinal 6.11  102586-39-0   Retinaldehyde/*analogs & derivatives. Biophys J 1993 Aug;65(2):964-72
10,20-methanoretinal  128434-80-0   Retinaldehyde/*analogs & derivatives. Eur J Biochem 1990;191(1):211
14-fluororetinal  68200-23-7   Retinaldehyde/*analogs & derivatives. Biochemistry 1990;29(25):5948
4-hydroxyretinal  18344-42-8 Retinal, 4-hydroxy  Retinaldehyde/*analogs & derivatives Pigments, Biological Decapodiformes. Biochim Biophys Acta 1988;966(3):370
3-hydroxyretinal oxime  7163-02-2   Retinaldehyde/*analogs & derivatives. Vision Res 1986;26(2):255
3-hydroxyretinal  6890-91-1   Retinaldehyde/*analogs & derivatives. Vision Res 1986;26(2):255
5,6-epoxy-3-dehydroretinal  20008-03-1   Retinaldehyde/*analogs & derivatives Stereoisomerism. Eur J Biochem 1985;147(2):255
3-diazirinophenylretinal  83374-72-5 2,4,6,8-Nonatetraenal, 9-(3-(3H-diazirin-3-yl)phenyl)-3,7-dimethyl-, (all-E)  *Azirines Retinaldehyde/*analogs & derivatives. J Biol Chem 1982;257(22):13616
retinal palmitate  0   Retinaldehyde/*analogs & derivatives. Biochem Biophys Res Commun 1982;104(2):430
9-cis-retinal  514-85-2   *Retinaldehyde Isomerism. Biophys J 1980;31(1):139
13-cis-retinal  472-86-6   *Retinaldehyde Isomerism. Biophys J 1980;31(1):139
phenyl retinal  75001-15-9 2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-phenyl-, (all-E)  Retinaldehyde/*analogs & derivatives. J Biol Chem 1981;256(8):3797
5,6-dihydro-1,1,5,9,13-desmethylretinal  76080-85-8 2,4,6,8-Nonatetraenal, 9-cyclohexyl-, (all-E)  Retinaldehyde/*analogs & derivatives. Biochemistry 1981;20(2):429
5,6-dihydroretinal  19907-28-9 retinal, 5,6-dihydro  Retinaldehyde/*analogs & derivatives. Biochemistry 1981;20(2):429
5,6-epoxyretinal  739-13-9 5,6-epoxy-5,6-dihydroretinal  Retinaldehyde/*analogs & derivatives. J Nutr Sci Vitaminol (Tokyo) 25(4):343;1979
11-cis-retinal-binding protein  0   *Carrier Proteins Retinaldehyde. J Biol Chem 254(17):8529;1979; Methods Enzymol 1980;67:296
9,13-dicis-retinal  0   Retinaldehyde/*analogs & derivatives Stereoisomerism. Invest Ophthal Visual Sci 17(10):1024;1978
retinal acetylhydrazone  61630-48-6   Retinaldehyde/*analogs & derivatives. Cancer Res 38(10):3328;1978
dehydroretinal  472-87-7 3,4-didehydroretinal  Retinaldehyde/*analogs & derivatives. Biochemistry 17(10):1915;1978
11,12-dihydroretinal  41889-27-4 Retinal, 11,12-dihydro  Retinaldehyde/*analogs & derivatives. J Am Chem Soc 99(23):7720;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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