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RNA-Directed DNA Polymerase

More information in Books or onNLM PubMed
Definition: An enzyme that synthesizes DNA on an RNA template. It is encoded by the pol gene of retroviruses and by certain retrovirus-like elements. EC 2.7.7.49.     
Examples HIV Reverse Transcriptase; Telomerase 		Other names Reverse Transcriptase; RNA-Dependent DNA Polymerase; DNA Polymerase, RNA-Directed; RNA Directed DNA Polymerase; RNA Dependent DNA Polymerase; DNA Polymerase, RNA-Dependent; DNA Polymerase, RNA Directed; RNA Transcriptase; Revertase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5,11-dihydro-11-ethyl-5-methyl-8-(2-(1-oxido-4-quinolinyl)ethyl)-6H-dipyrido(3,2-B,2',3'-E)(1,4)diazepin-6-one  0   *Azepines *Pyridines RNA-Directed DNA Polymerase. J Pharm Biomed Anal 2010 Apr 6;51(5):1047-53
nMat2 protein, Arabidopsis  EC 2.7.7.49   *RNA-Directed DNA Polymerase *Arabidopsis Proteins. RNA 2009 Dec;15(12):2351-63
2-(ethoxymethylthio)-9-phenylcyclohepta(d)pyrimidone  0   *Pyrimidinones RNA-Directed DNA Polymerase. Cell Biol Int 2009 Feb;33(2):207-16
ORF2 protein, human  0   *Endonucleases *RNA-Directed DNA Polymerase. Genomics 1987 Oct;1(2):113-25
UK 453,061  0   *Nitriles *Pyrazoles RNA-Directed DNA Polymerase. Xenobiotica 2008 Jun;38(6):620-40
nMat1a protein, Arabidopsis  EC 2.7.7.49   *RNA-Directed DNA Polymerase *Arabidopsis Proteins. Plant Cell Physiol 2006 Jun;47(6):772-83
MC 1220  0   *Pyrimidinones RNA-Directed DNA Polymerase/antagonists & inhibitors. J Med Chem 2005 Nov 3;48(22):6776-8
ORF2 protein, Drosophila  0   *RNA-Directed DNA Polymerase *Drosophila Proteins Endonucleases. Nucleic Acids Res 2005;33(2):776-85
reverse transcriptase Ty3, S cerevisiae  EC 2.7.7.49   *RNA-Directed DNA Polymerase *Saccharomyces cerevisiae Proteins. Nucleic Acids Res 2005;33(1):171-81
L1 ORF2 protein, human  0   *Endonucleases *RNA-Directed DNA Polymerase. Hum Mol Genet 2004 May 15;13(10):1041-8
maturase I-AniI  EC 2.7.7.49   *RNA-Directed DNA Polymerase. RNA 2002 Apr;8(4):412-25
MC1047  0   *Pyrimidinones RNA-Directed DNA Polymerase/antagonists & inhibitors. Chirality 2001 Feb;13(2):75-80
R2 reverse transcriptase, Bombyx mori  EC 2.7.7.-   *RNA-Directed DNA Polymerase *Insect Proteins. Mol Cell Biol 1996 Sep;16(9):4726-34
LtrA protein, Lactococcus lactis  EC 2.7.7.49   *Bacterial Proteins *RNA-Directed DNA Polymerase. J Bacteriol 1996 Jun;178(12):3531-8
aI1 endonuclease  EC 2.7.7.-   *RNA-Directed DNA Polymerase. Nature 1996 May 23;381(6580):332-5
primase-reverse transcriptase complex  0   *Multienzyme Complexes *RNA-Directed DNA Polymerase *Ribonuclease H *DNA Primase. Eur J Biochem 1991;195(1):157
aI2 protein, S cerevisiae  EC 2.7.7.-   *RNA-Directed DNA Polymerase *Saccharomyces cerevisiae Proteins. Mol Gen Genet 1990;223(2):249
P protein, Hepatitis B virus  0   *Gene Products, pol Hepatitis B virus RNA-Directed DNA Polymerase. J Virol 1990;64(11):5324

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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