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Ribonucleotide Reductases

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Definition:      
Examples Ribonucleoside Diphosphate Reductase 		Other names Reductases, Ribonucleotide; Reductase, Ribonucleotide; Ribonucleotide Reductase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
NrdB protein, E coli  EC 1.17.4.-   *Ribonucleotide Reductases *Escherichia coli Proteins. J Bacteriol. 1976 Dec;128(3):810-4.
RNR2 protein, S cerevisiae  EC 1.17.4.-   *Ribonucleotide Reductases *Saccharomyces cerevisiae Proteins. Biochem Cell Biol. 1989 Jul;67(7):352-7.
p53R2 protein, zebrafish  EC 1.17.4.-   *Ribonucleotide Reductases *Zebrafish Proteins Protein Subunits. Gene 2011 Apr 1;475(1):30-8
Rnr1 protein, S cerevisiae  EC 1.17.4.-   *Ribonucleotide Reductases *Saccharomyces cerevisiae Proteins. Nucleic Acids Res 2010 Jul 1;38(12):3975-83
2'-(2-hydroxyethyl)-2'-deoxyadenosine 5'-phosphate  0   Adenosine Triphosphate/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors. ChemMedChem 2009 Oct;4(10):1649-56
2'-(2-hydroxyethyl)-2'-deoxyadenosine  0   *Deoxyadenosines Ribonucleotide Reductases/antagonists & inhibitors. ChemMedChem 2009 Oct;4(10):1649-56
NrdF protein, E coli  EC 1.17.4.-   *Ribonucleotide Reductases *Escherichia coli Proteins Protein Subunits. Proc Natl Acad Sci U S A 2008 Sep 23;105(38):14383-8
NrdE protein, E coli  EC 1.17.4.-   *Ribonucleotide Reductases *Escherichia coli Proteins Protein Subunits. Proc Natl Acad Sci U S A 2008 Sep 23;105(38):14383-8
ribonucleotide reductase 2B, Arabidopsis  EC 1.17.4.-   *Ribonucleotide Reductases *Arabidopsis Proteins Protein Subunits. Plant Cell 2006 Feb;18(2):350-65
ribonucleotide reductase 2A, Arabidopsis  EC 1.17.4.-   *Ribonucleotide Reductases *Arabidopsis Proteins Protein Subunits. Plant Cell 2006 Feb;18(2):350-65
TSO2 protein, Arabidopsis  EC 1.17.4.-   *Ribonucleotide Reductases *Arabidopsis Proteins Protein Subunits. Plant Cell 2006 Feb;18(2):350-65
3'-C-methyladenosine  0   Adenosine/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors. J Med Chem 2005 Jul 28;48(15):4983-9
NrdJb protein, Pseudomonas aeruginosa  EC 1.17.4.-   *Bacterial Proteins *Ribonucleotide Reductases. J Biol Chem 2005 Apr 29;280(17):16571-8
NrdJa protein, Pseudomonas aeruginosa  EC 1.17.4.-   *Bacterial Proteins *Ribonucleotide Reductases. J Biol Chem 2005 Apr 29;280(17):16571-8
RRR1 protein, Xenopus  EC 1.17.4.-   *Ribonucleotide Reductases *Xenopus Proteins.
Rrm1 protein, mouse  EC 1.17.4.1   *Ribonucleotide Reductases.
NrdG protein, E coli  EC 1.17.4.-   *Ribonucleotide Reductases *Escherichia coli Proteins.
nrdG protein, Enterobacteria phage T4  EC 1.17.4.-   *Ribonucleotide Reductases *Viral Proteins.
Rrm2b protein, mouse  EC 1.17.4.-   *Ribonucleotide Reductases *Cell Cycle Proteins DNA Repair.
m45 protein, Mouse cytomegalovirus 1  EC 1.17.4.-   *Ribonucleotide Reductases *Viral Proteins. Science 2001 Jan 12;291(5502):303-5
ADP-S-HBES-S-dGTP  0   *Nucleotides Ribonucleotide Reductases/antagonists & inhibitors. Bioorg Med Chem Lett 2000 Oct 16;10(20):2387-9
acetyl-phenylalanyl-threonyl-leucyl-aspartyl-alanyl-aspartyl-phenylalanine  0   *Peptide Fragments *Ribonucleotide Reductases Ribonucleotide Reductases/antagonists & inhibitors. J Med Chem 2001 Jan 4;44(1):36-46
nrdG protein, Lactococcus lactis  0   *Bacterial Proteins *Iron-Sulfur Proteins Ribonucleotide Reductases. J Biol Chem 2000 Apr 28;12367-73
RRM2B protein, human  EC 1.17.4.-   *Ribonucleotide Reductases *Cell Cycle Proteins DNA Repair. Nature 2000 Mar 2;404(6773):42-9
U28 protein, Human herpesvirus  EC 1.17.4.1   *Ribonucleotide Reductases *Viral Proteins. J Gen Virol 1999 Oct;80 ( Pt 10):2713-8
6-methyl-2-isopropylsulfonyloxy-1(H)-isoindole-1,3-dione  0   *Isoindoles Ribonucleotide Reductases/antagonists & inhibitors. Anticancer Res 1999 May-Jun;19(3A):1625-34
2-hydroxy-1(H)-isoindole-1,3-dione  0   *Isoindoles Ribonucleotide Reductases/antagonists & inhibitors. Anticancer Res 1999 May-Jun;19(3A):1625-34
NrdG protein, Alcaligenes  EC 1.17.4.-   *Bacterial Proteins *Ribonucleotide Reductases. J Bacteriol 1999 Aug;181(16):4919-28
NrdD protein, Alcaligenes  EC 1.17.4.-   *Bacterial Proteins *Ribonucleotide Reductases. J Bacteriol 1999 Aug;;181(16):4919-28
NrdF protein, bacteria  EC 1.17.4.-   *Bacterial Proteins *Ribonucleotide Reductases. Biochemistry 1998 Sep 22;37(38):13359-69
BILD 1633 SE  0   *Oligopeptides Ribonucleotide Reductases/antagonists & inhibitors. Antimicrob Agents Chemother 1998 Jul;42(7):1629-35
2'-azido-2'-deoxyuridine  26929-65-7   *Azides Deoxyuridine/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors. Nucleosides Nucleotides 1998 Jun;17(6):1077-88
ribonucleotide reductase R2 subunit  EC 1.17.4.-   *Ribonucleotide Reductases. FEBS Lett 1997 Sep 8;414(2):449-53
BILD 1357  0   *Oligopeptides Ribonucleotide Reductases/antagonists & inhibitors. J Med Chem 1996 Oct 11;39(21):4173-80
BILD 1351  0   *Dipeptides Urea/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors. J Med Chem 1996 Oct 11;39(21):4173-80
anaerobic ribonucleotide reductase  EC 1.17.4.-   *Ribonucleotide Reductases Bacterial Proteins Viral Proteins Escherichia coli Proteins. J Biol Chem 1996 Aug 23;271(34):20770-5
ICP10 protein, herpes simplex virus type 2  EC 1.17.4-   *Ribonucleotide Reductases *Protein-Serine-Threonine Kinases. J Biol Chem 1996 Jul 19;271(29):17021-7
BILD 733  0   *Oligopeptides Ribonucleotide Reductases/antagonists & inhibitors. J Virol 1996 Feb;70(2):787-93
cladribine triphosphate  0   Adenosine Triphosphate/*analogs & derivatives Cladribine/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors. Blood 1996 Jan 1;87(1):256-64
N-acetyltyrosyl-threonyl-leucyl-aspartyl-alanyl-aspartyl-phenylalanine  0   *Oligopeptides Ribonucleotide Reductases/antagonists & inhibitors. Struct Biol 1995 Nov;2(11):951-5
BILD 1263  0   *Oligopeptides Ribonucleotide Reductases/antagonists & inhibitors. Nature 1993 Dec 15;372(6507):695-8
nrdG protein, bacteria  EC 1.17.4.-   *Bacterial Proteins *Ribonucleotide Reductases. J Biol Chem 1994 Nov 11;269(45):27815-8
SUC22 protein, S pombe  EC 1.17.4.1   *Ribonucleotide Reductases *Schizosaccharomyces pombe Proteins Schizosaccharomyces. Mol Gen Genet 1993 Apr;238(1-2):241-51
cdc22 protein, S pombe  0   *Cell Cycle Proteins *Schizosaccharomyces pombe Proteins Ribonucleotide Reductases Schizosaccharomyces. Mol Gen Genet 1993 Apr;238(1-2):241-51
3,4,5-trihydroxybenzamidoxime  0   *Benzamidines Ribonucleotide Reductases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Free Radical Scavengers 		Ann Thorac Surg 1992 Jun;53(6):1091-5
compound 348U87  127142-14-7   *Hydrazones *Pyridines Ribonucleotide Reductases/antagonists & inhibitors. Biochem Pharmacol 1991;42(1):91
resveratrol  501-36-0   *Stilbenes Phenols Ribonucleotide Reductases/antagonists & inhibitors Vasodilator Agents Angiogenesis Inhibitors.
Pharma Action Anti-Inflammatory Agents, Non-Steroidal ; Antineoplastic Agents, Phytogenic ; Antioxidants ; Enzyme Inhibitors ; Platelet Aggregation Inhibitors ; Antimutagenic Agents ; Anticarcinogenic Agents 		Pharmacol Res Commun 1988;20 Suppl 5:79
A 1110U  96860-23-0   *Hydrazones *Pyridines Ribonucleotide Reductases/antagonists & inhibitors. Proc Natl Acad Sci USA 1989;86(3):1051
herpes simplex virus H2 (6-15), 4'-azido-Phe(6)  0   *Azides *Oligopeptides Ribonucleotide Reductases/antagonists & inhibitors Immunodominant Epitopes. J Biol Chem 1988;263(31):16045
ribonucleoside-triphosphate reductase  EC 1.17.4.2   *Ribonucleotide Reductases. Biochemistry 1988;27(12):4305
gemcitabine  103882-84-4   Deoxycytidine/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors.
Pharma Action Antimetabolites, Antineoplastic ; Antiviral Agents ; Enzyme Inhibitors ; Immunosuppressive Agents ; Radiation-Sensitizing Agents 		Cancer Res 1988;48(14):4024GEMCITABINE; GEMCITABINE HYDROCHLORIDE; GEMZAR
herpes simplex virus type 1-protein ICP6  0   *Viral Proteins Ribonucleotide Reductases Simplexvirus. J Virol 1987;62(1):196
2'-chloro-2'-deoxyuridine 5'-diphosphate  40111-66-8 Uridine 5'-(trihydrogen diphosphate), 2'-chloro-2'-deoxy  *Deoxyuracil Nucleotides Ribonucleotide Reductases/antagonists & inhibitors. Biochemistry 1985;24(25):7214
alpha beta, beta gamma-dimethylenedeoxythymidine 5'-triphosphate  90094-77-2 Thymidine, 5'-(hydrogen ((hydroxy(phosphonomethyl)phosphinyl)methyl)phosphonate)  *Thymine Nucleotides Ribonucleotide Reductases/antagonists & inhibitors. Adv Exp Med Biol 1984;165(pt B):371
beta, gamma-methylenedeoxythymidine 5'-triphosphate  59957-94-7 5'-Thymidylic acid, monoanhydride with (phosphonomethyl)phosphonic acid  *Thymine Nucleotides Ribonucleotide Reductases/antagonists & inhibitors. Adv Exp Med Biol 1984;165(pt B):371
1-formylisoquinoline-thiosemicarbazone iron chelate  0   *Isoquinolines Ribonucleotide Reductases/antagonists & inhibitors. J Biol Chem 1983;258(7):4063
3,4-dihydroxybenzohydroxamic acid  69839-83-4 Benzamide, N,3,4-trihydroxy  *Hydroxamic Acids Ribonucleotide Reductases/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors 		Cancer Res 1982;42(8):2963
tobacco tar  0   *Tars Ribonucleotide Reductases/antagonists & inhibitors Tobacco.
Pharma Action Enzyme Inhibitors ; Immunosuppressive Agents 		Oral Surg 1980;49(5):435
2'-azidocytidine  51034-68-5   Cytidine/*analogs & derivatives Ribonucleotide Reductases/antagonists & inhibitors. Eur J Biochem 72(2):371;1977; J Virol 24(1):22;1977; Proc Natl Acad Sci USA 74(12):5310;1977
4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone  59261-39-1   *Isoquinolines Ribonucleotide Reductases/antagonists & inhibitors. Cancer Res 1979;39(11):4600; Cancer Res 37:1692;1977; Cancer Treat Rep 63(3):449;1979; J Med Chem 19(7):970;1976
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