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RNA Cap Analogs

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Definition: Analogs of RNA cap compounds which do not have a positive charge. These compounds inhibit the initiation of translation of both capped and uncapped messenger RNA.  IM; /drug eff /ultrastruct permitted    Other names Cap Analogues, RNA; Cap Analogs, RNA; Analogues, RNA Cap; Analogs, RNA Cap; RNA Cap Analogues
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
m(7)GpppsG nucleotide  0   *RNA Cap Analogs. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1301-5
m7GpppGm  0   *RNA Cap Analogs. Cell 1975 Sep;6(1):21-7
m7GpppA  0   *RNA Cap Analogs. Nucleic Acids Res 1979;6(6):2179-91
7-methylguanosine 5'-diphosphate  104809-16-7   Guanosine Diphosphate/*analogs & derivatives RNA Cap Analogs. Cell 1997 Jun 13;89(6):951-61
gamma-(4-aminophenyl) 7-methylguanosine 5'-triphosphate  88106-70-1   Guanosine Triphosphate/*analogs & derivatives RNA Cap Analogs. Biochemistry 1984;23(2):177
7-methylguanosine-5'-triphosphoryl-2'-O-methylguanosine  57718-00-0 guanosine 5'-(tetrahydrogen triphosphate), 2'-O-methyl-, 5'-5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-beta-D-ribofuranosyl-1H-purinium hydroxide, inner salt  *RNA Cap Analogs. Biochem Biophys Res Commun 1980;96(1):400
2'-O-methylguanosine 5'-triphosphate  61556-44-3 Guanosine 5'-(tetrahydrogen triphosphate), 2'-O-methyl  *RNA Cap Analogs. Eur J Biochem 1980;103(1):125
7-ethylguanosine  71369-24-9 1H-Purinium, 2-amino-7-ethyl-6,9-dihydro-6-oxo-9-beta-D-ribofuranosyl  *RNA Cap Analogs. J Biol Chem 254(14):6732;1979
m(7)GpppAm  0   *RNA Cap Analogs. J Biol Chem 254(2):459;1979
m(7)GMP  0   *RNA Cap Analogs. Cell 1980;19(1):69; J Biochem (Tokyo) 84(5):1125;1978; J Biol Chem 253(19):6630;1978
m(7)GDP  0   *RNA Cap Analogs. J Biol Chem 253(19):6630;1978
7-methylguanosine triphosphate  26554-26-7 2-amino-6,9-dihydro-9-(5-O-(hydroxy((hydroxy(phosphonooxy)phosphinyl)oxy)phosphinyl)-beta-D-ribofuranosyl)-7-methyl-6-oxo-1H-purinium, hydroxide, inner salt  *RNA Cap Analogs. Biochemistry 17(12):2450;1978; Biochemistry 19(1):184;1980; Eur J Biochem 1980;103(1):125; Eur J Biochem 92(1):469;1979; Nucleic Acids Res 6(6):2179;1979
7-methylguanosine-5'-monophosphate  10162-58-0   *RNA Cap Analogs. Biochem Biophys Res Commun 76(1):32;1977; Biochem Biophys Res Commun 82(2):553;1978; Biochemistry 17(12):2450;1978; Eur J Biochem 1980;103(1):125; Eur J Biochem 88(2):483;1978; Eur J Biochem 92(1):461;1979; Proc Natl Acad Sci USA 73(1):19;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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