encyclopedia of medical concepts
ψ 
ψ 
ψ 
ψ 

RNA Caps

More information in Books or onNLM PubMed
Definition: Nucleic acid structures found on the 5' end of eukaryotic cellular and viral messenger RNA and some heterogeneous nuclear RNAs. These structures, which are positively charged, protect the above specified RNAs at their termini against attack by phosphatases and other nucleases and promote mRNA function at the level of initiation of translation. Analogs of the RNA caps (RNA CAP ANALOGS), which lack the positive charge, inhibit the initiation of protein synthesis.  IM; /drug eff /ultrastruct permitted   
Examples RNA Cap Analogs 		Other names RNA, 5' Capped; Caps, RNA; 5' mRNA Cap Structure; 5' Capped RNA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7P(1)-3'-deoxy-7-methyguanosine-5' P3-guanosine-5' triphosphate  0   *Dinucleoside Phosphates RNA Caps. RNA 2001 Oct;7(10):1486-95
P(1)-3'-O,7-dimethylguanosine-5' P3-guanosine-5' triphosphate  0   *Dinucleoside Phosphates RNA Caps. RNA 2001 Oct;7(10):1486-95
VP39 protein, Vaccinia virus  0   *Viral Proteins Methyltransferases Polynucleotide Adenylyltransferase RNA Caps Vaccinia virus. J Biol Chem 1994 Aug 12;269(32):20700-6
reovirus protein lambda2  0   *Nucleotidyltransferases *Viral Core Proteins RNA Caps. Virology 1991;185(1):376
7-methyl-diguanosine triphosphate  62828-64-2   *Dinucleoside Phosphates RNA Caps. Biochemistry 1989;28(20):8078
capping enzyme, vaccinia virus  EC 2.-   *Methyltransferases *Multienzyme Complexes *Nucleotidyltransferases *Phosphoric Monoester Hydrolases RNA Caps Vaccinia virus. J Biol Chem 1980;255(23):11588
N(6),N(6)-dimethyladenosine  2620-62-4   Adenosine/*analogs & derivatives RNA Caps. J Biol Chem 254(18):9085;1979; J Biol Chem 254(18):9090;1979; J Biol Chem 254(18):9094;1979
guanosine 5'-triphosphate-5'-adenosine  10527-47-6 Guanosine 5'-(tetrahydrogen-triphosphate), 5'-5'-ester with adenosine  *Dinucleoside Phosphates RNA Caps. J Biol Chem 253(14):4960;1978
7-methylguanosine  2140-77-4   Guanosine/*analogs & derivatives RNA Caps. Anal Biochem 1979;98(1):102; Biochem Biophys Res Commun 84(4):886;1978; Biochemistry 17(12):2450;1978; Biochemistry 1979;18(17):3804; Biochemistry 1979;18(18):4017; Biochim Biophys Acta 518(2):321;1978; Can J Biochem 57(6):927;1979; Chem Biol Interact 1980;29(2):197; Chem Biol Interact 26(2):227;1979; Clin Chim Acta 1979;97(2-3):159; Eur J Biochem 92(1):69;1978; Eur J Biochem 97(2):615;1979; FEBS Lett 96(1):1;1978; J Bacteriol l979;140(2):408; J Biol Chem 1979;254(19):9345; J Biol Chem 253(22):8278;1978; J Biol Chem 254(5):1440;1979; Monogr Hum Genet 10:135;1978; Nucleic Acids Res 5(12):4877;1978; Proc Natl Acad Sci USA 75(10):4843;1978
N(6)-methyladenosine  1867-73-8   Adenosine/*analogs & derivatives RNA Caps. Biochemistry 17(13):2573;1978; Can J Biochem 57(6):927;1979; J Mol Biol 124(3):487;1978; J Virol 1979;32(1):52; Nucleic Acids Res 6(8):2879;1979; Vopr Med Khim 21(2):192;1975

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy