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RNA Polymerase I

More information in Books or onNLM PubMed
Definition: A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. The enzyme functions in the nucleolar structure and transcribes DNA into RNA. It has different requirements for cations and salts than RNA polymerase II and III and is not inhibited by alpha-amanitin. EC 2.7.7.6.      Other names DNA-Dependent RNA Polymerase I; Polymerase I, RNA; Polymerase A, RNA; I, RNA Polymerase; DNA Dependent RNA Polymerase I; A, RNA Polymerase; RNA Polymerase A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CX 5461  0   *Naphthyridines *Benzothiazoles RNA Polymerase I/antagonists & inhibitors. Cancer Res 2011 Feb 15;71(4):1418-30
RPA12 protein, S cerevisiae  EC 2.7.7.-   *RNA Polymerase I *Saccharomyces cerevisiae Proteins. Mol Gen Genet 2001 Feb;264(6):852-9
rpc19 protein, S pombe  0   *DNA-Directed RNA Polymerases *Schizosaccharomyces pombe Proteins RNA Polymerase I RNA Polymerase II. Mol Gen Genet 1999 Mar;261(2):364-73
RPA14 protein, S cerevisiae  0   *RNA Polymerase I *Saccharomyces cerevisiae Proteins. J Biol Chem 1995 Jun 2;270(22):13534-40
9-beta-xylofuranosyladenine 5'-triphosphate  653-60-1   Adenosine Triphosphate/*analogs & derivatives RNA Polymerase I/antagonists & inhibitors RNA Polymerase II/antagonists & inhibitors. J Biochem (Tokyo) 1985;97(5):1385

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