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DNA-Directed RNA Polymerases

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Definition: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).  GEN or unspecified; prefer specifics RNA POLYMERASE I, etc.   
Examples DNA Primase; RNA Polymerase I; RNA Polymerase II; RNA Polymerase III; RNA Polymerase Sigma 54 		Other names Transcriptases; RNA Polymerases; DNA-Dependent RNA Polymerases; RNA Polymerases, DNA-Directed; RNA Polymerases, DNA-Dependent; RNA Polymerase, DNA-Directed; Polymerases, RNA; Polymerases, DNA-Directed RNA; Polymerases, DNA-Dependent RNA; Polymerase, RNA; Polymerase, DNA-Directed RNA; DNA Directed RNA Polymerases; DNA Directed RNA Polymerase; DNA Dependent RNA Polymerases; Transcriptase; RNA Polymerase; DNA-Directed RNA Polymerase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
RpoZ protein, E coli  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Escherichia coli Proteins Protein Subunits. Gene. 1986;48(1):33-40.
POLR1C protein, human  EC 2.7.7.6   *DNA-Directed RNA Polymerases Protein Subunits. Nat Genet. 2011 Jan;43(1):20-2.
POLR1D protein, human  EC 2.7.7.6   *DNA-Directed RNA Polymerases Protein Subunits. Nat Genet. 2011 Jan;43(1):20-2.
cyclothiazomycin B1  0   *Peptides DNA-Directed RNA Polymerases/antagonists & inhibitors. Bioorg Med Chem. 2011 Sep 15;19(18):5300-10.
Rpo41 protein, S pombe  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Schizosaccharomyces pombe Proteins Mitochondrial Proteins. Nucleic Acids Res 2011 Jul;39(12):5119-30
MTPAP protein, human  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Mitochondrial Proteins. Am J Hum Genet 2010 Nov 12;87(5):655-60
RNA polymerase V, Arabidopsis  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Arabidopsis Proteins. Mol Cell 2009 Jan 30;33(2):192-203
RpoTmp protein, Arabidopsis  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Arabidopsis Proteins Mitochondrial Proteins. Nucleic Acids Res 2004 Feb 18;32(3):1159-65
RpoTp protein, Arabidopsis  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Arabidopsis Proteins. Plant Physiol 2006 Jul;141(3):942-56
POLRMT protein, human  EC 2.7.7.6   *DNA-Directed RNA Polymerases. Trends Biochem Sci 2007 Mar;32(3):111-7
POLR2E protein, human  EC 2.7.7.6   *DNA-Directed RNA Polymerases. EMBO J 1995 Jan 3;14(1):143-50
Rbp5 protein, S cerevisiae  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Saccharomyces cerevisiae Proteins Protein Subunits. Genes Dev 1990 Mar;4(3):313-23
L polymerase protein, Vesicular stomatitis-Indiana virus  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Viral Proteins. Virology. 2006 Jul 5;350(2):394-405
Rpc19p protein, S cerevisiae  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Saccharomyces cerevisiae Proteins. Genetics. 2005 Aug;170(4):1515-24
SMYD3 protein, human  EC 2.1.1.43   *Histone-Lysine N-Methyltransferase DNA-Directed RNA Polymerases Zinc Fingers. Nat Cell Biol 2004 Aug;6(8):731-40
Trf5 protein, S cerevisiae  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2005 Nov;25(22):10183-9
DRD1 protein, Arabidopsis  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Arabidopsis Proteins Protein Subunits. Curr Biol 2004 May 4;14(9):801-5
RNA polymerase IV, Arabidopsis  EC 2.7.7.-   *DNA-Directed RNA Polymerases. Science 2005 Apr 1;308(5718):118-20
GE 23077-B  0   *Peptides, Cyclic DNA-Directed RNA Polymerases/antagonists & inhibitors. Eur J Biochem 2004 Aug;271(15):3146-54
GE 23077-A  0   *Peptides, Cyclic DNA-Directed RNA Polymerases/antagonists & inhibitors. Eur J Biochem 2004 Aug;271(15):3146-54
RPO41 protein, S cerevisiae  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Mitochondrial Proteins *Saccharomyces cerevisiae Proteins. Protein Expr Purif 2004 May;35(1):126-30
RpoTp protein, Hordeum vulgare  EC 2.7.7.6   *DNA-Directed RNA Polymerases Plant Proteins. Plant J 2004 May;38(3):460-72
RpoTm protein, Hordeum vulgare  EC 2.7.7.6   *DNA-Directed RNA Polymerases Plant Proteins. Plant J 2004 May;38(3);460-72
RPO26 protein, S cerevisiae  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Saccharomyces cerevisiae Proteins.
CBR 9393  0   *Piperazines *Pyrazoles DNA-Directed RNA Polymerases/antagonists & inhibitors. Science 2003 Oct 24;302(5645):650-4
CBR 9379  0   *Hydroxylamines *Phenylurea Compounds DNA-Directed RNA Polymerases/antagonists & inhibitors. Science 2003 Oct 24;302(5645):650-4
CBR 703  0   *Amidines *Hydroxylamines DNA-Directed RNA Polymerases/antagonists & inhibitors. Science 2003 Oct 24;302(5645):650-4
Taq sigma A  EC 2.7.7.6   *DNA-Directed RNA Polymerases Thermus. Science 2002 May 17;29695571):1280-4
NsRpoT-B protein, Nicotiana sylvestris  EC 2.7.7.-   *Plant Proteins *DNA-Directed RNA Polymerases. Biochem Biophys Res Commun 2001 Dec 21;289(5):1106-13
RpoK protein, Sulfolobus solfataricus  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Archaeal Proteins. J Biol Chem 2001 Dec 14;276(50):46693-6
L protein, Nipah virus  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Viral Proteins DNA-Directed RNA Polymerases. Virology 2001 Aug 15;287(1):192-201
Rpb8 protein, S cerevisiae  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 2001 Sep;21(17):6056-65
12-epi-hapalindole E isonitrile  0   *Indoles DNA-Directed RNA Polymerases/antagonists & inhibitors. FEMS Microbiol Lett 2001 Mar 15;196(2):135-9
Ro 32-7804  0   *Piperidines DNA-Directed RNA Polymerases/antagonists & inhibitors. Nucleic Acids Res 2001 Jul 1;29(13):2691-8
nucleus-encoded phage-type RNA polymerase  EC 2.7.7.-   *DNA-Directed RNA Polymerases. EMBO J 2000 Apr 17;19(8):1851-60
RNA polymerase sigma(28)  EC 2.7.7.-   *DNA-Directed RNA Polymerases. Genes Genet Syst 1999 Jun;74(3):113-6
rpc40 protein, S pombe  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Schizosaccharomyces pombe Proteins. Mol Gen Genet 1999 Dec;262(4-5):749-57
RPB6 protein, rat  EC 2.7.7.-   *DNA-Directed RNA Polymerases Phosphoproteins. Gene 1999 Jun 24;234(1):139-47
gene 2 product, bacteriophage T7  0   *Repressor Proteins DNA-Directed RNA Polymerases Viral Proteins. J Mol Biol 1999 Jun 18;289(4):815-26
RPO22 protein, Vaccinia virus  EC 2.7.7.6   *DNA-Directed RNA Polymerases *Viral Proteins Vaccinia virus. Virology 1999 Jun 5;258(2):469-79
rpc19 protein, S pombe  0   *DNA-Directed RNA Polymerases *Schizosaccharomyces pombe Proteins RNA Polymerase I RNA Polymerase II. Mol Gen Genet 1999 Mar;261(2):364-73
RNA polymerase alpha subunit  EC 2.7.7.6   *DNA-Directed RNA Polymerases Escherichia coli Proteins. Science 1998 Jul 10;281(5374):262-6
RNA polymerase omega subunit  EC 2.7.7.-   *DNA-Directed RNA Polymerases Trans-Activators. Genes Dev 1998 Mar 1;12(5):745-54
beta' subunit of RNA polymerase  EC 2.7.7.-   *DNA-Directed RNA Polymerases Escherichia coli Proteins. Gene 1997 Sep 1;196(1-2):31-42
RNA polymerase Esigma(38)  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Sigma Factor. J Bacteriol 1997 Jun;179(11):3649-54
RNA polymerase beta subunit  EC 2.7.7.6   *DNA-Directed RNA Polymerases. Gene 1997 Feb 28;186(2):227-35
P phosphoprotein, Rabies virus  0   *Phosphoproteins *Viral Structural Proteins Antigens, Viral DNA-Directed RNA Polymerases. J Gen Virol 1997 Jan;78(Pt 1):119-24
virus-infection-associated antigen, Foot-and-mouth disease virus  0   *Antigens, Viral *Viral Nonstructural Proteins DNA-Directed RNA Polymerases. J Vet Med Sci 1996 Jun;58(6):599-601
flutimide  162666-34-4   *Piperazines DNA-Directed RNA Polymerases/antagonists & inhibitors. Antimicrob Agents Chemother 1996 May;40(5):1189-93
L protein, Rabies virus  EC 2.7.7.48   *DNA-Directed RNA Polymerases *Viral Proteins. Virology 1995 Dec 20;214(2):522-30
ripostatin B  0   *Lactones DNA-Directed RNA Polymerases/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Aug;48(8):787-92
ripostatin A  0   *Lactones DNA-Directed RNA Polymerases/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Aug;48(8):787-92
RiSVs1gp1 protein, Rice stripe virus  0   *Viral Proteins *DNA-Directed RNA Polymerases Plant Viruses. J Gen Virol 1994 Dec;75(Pt 12):3569-79
nsP3 protein, virus  0   *Viral Nonstructural Proteins DNA-Directed RNA Polymerases RNA-Binding Proteins. J Virol 1994 Oct;68(10):6466-75
late expression factor 8, Baculovirus  0   *Viral Proteins DNA-Directed RNA Polymerases. J Virol 1994 Jul;68(7):4673-8
RAP94 protein, Vaccinia virus  0   *Viral Proteins DNA-Directed RNA Polymerases. J Virol 1994 March;68(3):1360-70
3D protein, Hepatitis A virus  0   *Viral Proteins Hepatovirus DNA-Directed RNA Polymerases. Virology 1994 Feb;198(2):524-33
RNA polymerase sigma 70  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Sigma Factor Bacterial Proteins DNA-Binding Proteins. J Biol Chem 1993 Jun 25;268(18):13023-5
bacteriophage T3 RNA polymerase  EC 2.7.7.-   *DNA-Directed RNA Polymerases. J Biochem Biophys Methods 1993 May;26(2-3):113-20
RNA polymerase sigma G  EC 2.7.7.-   *DNA-Directed RNA Polymerases *Sigma Factor. J Gen Microbiol 1992 Dec;138 (Pt 12):2609-18
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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