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RNA Replicase

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Definition: An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)      Other names RNA-Dependent RNA Polymerase; Replicase, RNA; RNA Polymerase, RNA-Directed; RNA Polymerase, RNA-Dependent; RNA Directed RNA Polymerase; RNA Dependent RNA Polymerase; RNA-Directed RNA Polymerase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(4-((4-(acetylamino)-4'-chloro-(1,1'-biphenyl)-2-yl)methoxy)phenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid  0   *Acetamides *Benzimidazoles RNA Replicase/antagonists & inhibitors. Antiviral Res. 2012 Jan;93(1):30-8.
2'-deoxy-2'-spirocyclopropylcytidine  0   *Spiro Compounds Cytidine/*analogs & derivatives RNA Replicase/antagonists & inhibitors. J Med Chem 2010 Nov 25;53(22):8150-60
6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-(1,2,4)triazolo(1,5-a)pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one  0   *Pyrones *Triazoles RNA Replicase/antagonists & inhibitors. J Med Chem 2009 Mar 12;52(5):1255-8
Nsp1 protein, SARS coronavirus  EC 2.7.7.48   *RNA Replicase *Viral Nonstructural Proteins. J Virol 2004 Dec;78(24):13600-12
RDR2 protein, Arabidopsis  EC 2.7.7.48   *RNA Replicase *Arabidopsis Proteins. Plant Cell 2006 Jul;18(7):1559-74
5-((4-bromophenyl)methyl)-2-phenyl-5H-imidazo(4,5-c)pyridine  0   *Imidazoles *Pyridines RNA Replicase/antagonists & inhibitors. J Virol 2006 Jan;80(1):149-60
5-nitrocytidine  0   Cytidine/*analogs & derivatives RNA Replicase/antagonists & inhibitors. J Med Chem 2006 Oct 19;49(21):6166-9
RDR6 protein, Arabidopsis  EC 2.7.7.48   *RNA Replicase *Arabidopsis Proteins. Plant Cell Physiol 2006 Jul;47(7):853-63
2-(4-(4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-ylmethoxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid  0   *Benzimidazoles RNA Replicase/antagonists & inhibitors. J Med Chem 2006 Jul 27;49(15):4721-36
nonstructural protein 15, SARS coronovirus  EC 2.7.7.48   *RNA Replicase *Viral Nonstructural Proteins. J Virol 2004 Sep;78(18):9977-86
nonstructural protein 3, SARS coronovirus  EC 2.7.7.48   *RNA Replicase *Viral Nonstructural Proteins. J Virol 2004 Sep;78(18):9977-86
1-(2-cyclopropylethyl)-3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-6-fluoro-4-hydroxy-2(1H)-quinolinone  0   *Thiadiazines *Quinolones RNA Replicase/antagonists & inhibitors. J Med Chem 2006 Feb 9;49(3):971-83
L protein, hantavirus  EC 2.7.7.48   *RNA Replicase *Viral Proteins. Arch Virol 2005 Mar;150(3):533-56
(5-cyano-8-methyl-1-propyl-1,3,4,9-tetrahydropyrano(3,4-b)indol-1-yl)acetic acid  0   *Indoles *Pyrans RNA Replicase/antagonists & inhibitors. Antimicrob Agents Chemother 2004 Dec;48(12):4813-21
SDE1 protein, Arabidopsis  EC 2.7.7.48   *RNA Replicase *Arabidopsis Proteins. Cell 2000 May 26;101(5):543-53
RdRP1 protein, Arabidopsis  EC 2.7.7.48   *RNA Replicase *Arabidopsis Proteins. Mol Plant Microbe Interact 2003 Mar;16(3):206-16
RNA-directed RNA polymerase RRF-3, C elegans  EC 2.7.7.48   *RNA Replicase. Curr Biol 2002 Aug 6;12(15):1317-9
SGS2 protein, Arabidopsis  0   *Arabidopsis Proteins RNA Replicase. Cell 2000 May 26;101(5):533-42
EGO-1 protein, C elegans  EC 2.7.7.-   *RNA Replicase *Caenorhabditis elegans Proteins. Curr Biol 2000 Feb 24;10(4):169-78
QDE1 protein, Neurospora crassa  EC 2.7.7.-   *Fungal Proteins *RNA Replicase. Nature 1999 May 13;399(6732):166-9
Aqr protein, mouse  EC 2.7.7.-   *RNA Replicase. Dev Dyn 1998 Jun;212(2):304-17
NS1 protein, Flavivirus  0   *Viral Nonstructural Proteins RNA Replicase. J Gen Virol 1996 Jun;77(Pt 6):1287-94
NS5 protein, flavivirus  0   *Viral Nonstructural Proteins Methyltransferases RNA Replicase. J Gen Virol 1995 Sep;76(Pt 9):2317-21
lambda3 protein, Reovirus  EC 2.7.7.-   *RNA Replicase *Viral Proteins Viral Core Proteins. Res Virol 1994 Sep-Oct;145(5):277-85
polymerase 3Dpol, poliovirus  EC 2.7.7.-   *RNA Replicase. J Biol Chem 1994 Nov 18;269(46):29173-81
NS-5 protein, hepatitis C virus  0   *Viral Nonstructural Proteins RNA Replicase. J Gen Virol 1994 May;75( Pt 5):1053-61
tobacco mosaic virus replicase  EC 2.7.7.-   *RNA Replicase Tobacco Mosaic Virus. Mol Plant Microbe Interact 1993 Sep-Oct;6(5):635-42
influenza virus polymerase basic protein 1  0   *Viral Proteins Orthomyxoviridae RNA Replicase. J Virol 1992 Nov;66(11):6314-21
PA protein, influenza viruses  0   *RNA Replicase *Viral Proteins Phosphoproteins. Virology 1989;172(2):601
nuclear inclusion protein a, mosaic viruses  EC 3.4.-   *Endopeptidases *Viral Proteins RNA Replicase. Biosci Biotechnol Biochem 1993 May;57(5):710-4; Virology 1989;170(2):362
PB2 protein, Influenzavirus A  0   *RNA Replicase *Viral Proteins. Bioorg Khim 1988;14(4):548
RNP transcriptase  EC 2.7.7.-   *RNA Replicase. Virus Res 1985;3(4):353
L protein, vesicular stomatitis virus  EC 2.7.7.48   *RNA Replicase *Viral Proteins Vesicular stomatitis Indiana virus. J Gen Virol 1984;65(Pt 3):663

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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