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Ryanodine

More information in Books or onNLM PubMed
Definition: A methylpyrrole-carboxylate from RYANIA that disrupts the RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL to modify CALCIUM release from SARCOPLASMIC RETICULUM resulting in alteration of MUSCLE CONTRACTION. It was previously used in INSECTICIDES. It is used experimentally in conjunction with THAPSIGARGIN and other inhibitors of CALCIUM ATPASE uptake of calcium into SARCOPLASMIC RETICULUM.     
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
8beta-amino-9alpha-hydroxyryanodine  0   Ryanodine/*analogs & derivatives. Biophys J. 2005 Apr;88(4):2585-96
10-O-succinoylryanodol  0   *Succinates Ryanodine/*analogs & derivatives. J Gen Physiol 2003 Jun;121(6):551-61
C4,C12-diketopyridylryanodine  0   Ryanodine/*analogs & derivatives. J Biol Chem 2003 Apr 18;278(16):14237-48
21-amino-9-hydroxyryanodine  0   Ryanodine/*analogs & derivatives. J Gen Physiol 1998 Jul;112(1):55-69
ryanotoxin  179987-30-5   *Scorpion Venoms Ryanodine. Biophys J 1996 Aug;71(2):707-21
spiganthine  0   Ryanodine/*analogs & derivatives. J Nat Prod 1995 Jul;58(7):1092-6
3-iodobenzyloxycarbonyl-beta-alanylryanodine  0   Ryanodine/*analogs & derivatives Iodine Radioisotopes. Eur J Pharmacol 1994 Aug 16;268(3):365-73
9-hydroxy-21-(4-azidobenzoyloxy)-9-epiryanodine  154504-97-9   Ryanodine/*analogs & derivatives. Anal Biochem 1994 Apr;218(1):55-62
10-O-(3-(4-azidobenzamido)propionyl)ryanodine  154505-02-9   Ryanodine/*analogs & derivatives. J Biol Chem 1994 May 6;269(18):13076-9
ryanodyl 3-(pyridine-3-carboxylate)  137441-82-8   *Nicotinic Acids Ryanodine/*analogs & derivatives. J Nat Prod 1991 Jul-Aug;54(4):1147-9
9,21-didehydroryanodine  94513-55-0   Ryanodine/*analogs & derivatives. Jpn J Pharmacol 1989;51(4):531

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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