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Safrole

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Definition: Constituent of several essential oils, notably sassafras. It has been used as a topical antiseptic and it is carcinogenic to the liver so it is no longer used as a flavoring agent in foods.      Other names Shikimol; Shikimols; Safrols; Safroles; 4-Allyl-1,2-methylenedioxybenzenes; 4 Allyl 1,2 methylenedioxybenzene; 4-Allyl-1,2-methylenedioxybenzene; Safrol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol  0   Safrole/*analogs & derivatives Apoptosis. Vascul Pharmacol 2003 Oct;40(3):183-7
1-methoxy-3-(3,4-methylenedioxyphenyl)-2-propanol  0   Safrole/*analogs & derivatives Apoptosis. Vascul Pharmacol 2003 Oct;40(3):183-7
5-chloromethyl-6-propyl-1,3-benzodioxole  1938-32-5   Safrole/*analogs & derivatives. J Pharm Sci 1993 Aug;82(8):813-6
3'-hydroxyisosafrole  17581-86-1 2-Propen-1-ol, 3-(1,3-benzodioxol-5-yl)  Safrole/*analogs & derivatives. Chem Biol Interact 1986;59(1):73
1'-oxosafrole  30418-53-2   Safrole/*analogs & derivatives. Cancer Res 1984;44(8):3231
1'-sulfoxysafrole  64282-99-1 1,3-Benzodioxole-5-methanol, alpha-ethenyl-, hydrogen sulfate  Safrole/*analogs & derivatives. Cancer Res 1983;43(11):5163
1'-acetoxysafrole  34627-78-6   Safrole/*analogs & derivatives. Carcinogenesis 1982;3(8):929
dihydrosafrole  94-58-6   Safrole/*analogs & derivatives. Biomed Mass Spectrom 1982;9(8):323
isosafrole  120-58-1 5-(1-propenyl)-1,3-benzodioxole  *Safrole Isomerism. Biochem Biophys Res Commun 80(1):89;1978
3'-methylmercaptoisosafrole  40581-84-8   Safrole/*analogs & derivatives. Cancer Res 36(5):1686;1976
1'-hydroxysafrole  5208-87-7 alpha-ethenyl-1,3-benzodioxole-5-methanol  Safrole/*analogs & derivatives. Cancer Res 36(5):1686;1976; Cancer Res 37:1883;1977
safrole oxide  7470-44-2   Safrole/*analogs & derivatives. Biochem Pharmacol 23(20):2839;1974; Drug Metab Dispos 2(6):489;1974
sulfoxide  120-62-7   Safrole/*analogs & derivatives.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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