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Schiff Bases

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Definition: Condensation products of aromatic amines and aldehydes forming azomethines substituted on the N atom, containing the general formula R-N:CHR. (From Grant & Hackh's Chemical Dictionary, 5th ed)  IM general only; an imine: do not confuse with Schiff reagent nor PERIODIC ACID-SCHIFF REACTION    Other names Bases, Schiff; Base, Schiff; Schiff Base
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
10-(3-hydroxy-4-methoxy-phenylimino)-10H-anthracen-9-one  0   *Anthracenes *Schiff Bases. Bioorg Med Chem. 2011 Jul 15;19(14):4183-91.
N,N'-di-(4-decyloxysalicylidene)-1',6'-diaminohexane  0   *Diamines *Schiff Bases. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1654-9
binucleine 2  0   *Pyrazoles *Schiff Bases. ACS Chem Biol 2010 Nov 19;5(11):1015-20
2-((2-(2-(2-(2-hydroxy-5-methoxybenzylidene amino)phenyl)disufanyl)phenylimino)methyl)-4-methoxyphenol  0   *Benzyl Compounds *Schiff Bases. Talanta. 2011 Mar 15;84(1):34-41
DUO 3O  0   *Pyridinium Compounds *Schiff Bases Cholinergic Agents. J Comput Aided Mol Des 2011 Feb;25(2):145-61
N,N'-((5,5'-(quinoxaline-2,3-diyl)-bis(1H-pyrrole-5,2-diyl))bis(methanylylidene))dianiline  0   *Quinoxalines *Schiff Bases. Dalton Trans 2010 Dec 21;39(47):11344-52
N,N'-((5,5'-(quinoxaline-2,3-diyl)bis(1H-pyrrole-5,2-diyl))bis(methanylylidene))bis(4-methoxyaniline)  0   *Quinoxalines *Schiff Bases. Dalton Trans 2010 Dec 21;39(47):11344-52
nicotinyl tryptophanate  0   *Nicotinic Acids *Schiff Bases Tryptophan/*analogs & derivatives. Radiats Biol Radioecol. 2010 Jul-Aug;50(4): 472-4
nicotinyl tyrosinate  0   *Nicotinic Acids *Schiff Bases Tyrosine/*analogs & derivatives. Radiats Biol Radioecol. 2010 Jul-Aug;50(4): 472-4
1-(glucopyranosyl-2'-deoxy-2'-iminomethyl)-2-hydroxybenzene  0   *Schiff Bases Glucosamine/*analogs & derivatives. ACS Nano 2010 Jul 27;4(7):4061-73
(4-mercaptophenyliminomethyl)-2-methoxyphenol  0   *Schiff Bases *Sulfhydryl Compounds. Talanta 2010 Jun 15;81(4-5):1176-82
2-((4-fluorophenylimino)methyl)-3,5-dimethoxyphenol  0   *Schiff Bases Phloroglucinol/*analogs & derivatives. J Mol Model 2010 Mar;16(3):577-87
bis(salicylaldehyde)tetramethylethylenediimine  0   *Schiff Bases. J Sep Sci 2009 Sep;323(18):
poly(4-carboxyphenyl isocyanide)  0   *Polymers *Schiff Bases. J Am Chem Soc 2009 Aug 5;131(30):10719-32
4-chloro-4'-dimethylaminobenzylideneaniline  0   *Aniline Compounds *Schiff Bases. Spectrochim Acta A Mol Biomol Spectrosc 2009 Sep 15;74(1):78-83
N,N'-bis(5-((triphenylphosphonium)methyl)salicylidine)-o-phenylenediamine  0   *Organophosphorus Compounds *Schiff Bases. DNA Cell Biol 2009 Nov;28(11):589-96
2-((4-methylphenylimino)methyl)-6-methoxyphenol  0   *Schiff Bases Ligands. Molecules 2009;14(7):2501-13
bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II)  0   *Organometallic Compounds *Schiff Bases Copper. J Biol Chem 2007 Apr 20;282(16):12010-21
bis(5-bromo-2-hydroxybenzaldehyde)-1,2-propanediimine  0   *Schiff Bases. J Hazard Mater 2009 May 15;164(1):133-7
1,3,5-tris((2,3-dihydroxybenzylidene)aminomethyl)cyclohexane  0   *Cyclohexanes *Schiff Bases Ligands. Spectrochim Acta A Mol Biomol Spectrosc 2008 Dec 15;71(4):1452-60
N,N'-dipyridoxyl (1,3-propylenediamine)  0   *Schiff Bases Pyridoxine/*analogs & derivatives Ligands. Spectrochim Acta A Mol Biomol Spectrosc 2008 Dec 15;71(4):1341-7
2-((p-hydroxylphenylimino)methyl)phenol  0   *Schiff Bases. Cell Biochem Funct. 2007 Mar-Apr;25(2):149-58
2-((o-hydroxylphenylimino)methyl)phenol  0   *Schiff Bases. Cell Biochem Funct. 2007 Mar-Apr;25(2):149-58
N,N'-bis(salicylidene)-1.2-propanediamine  0   *Diamines *Schiff Bases. J Pharm Biomed Anal 2006 Mar 3;40(4):833-9
aminobenzanthrone  0   *Anthracenes *Schiff Bases. Anal Sci. 2006 Jul;22(7):977-81
2-pyridincarboxyaldehyde  0   *Aldehydes *Pyridines Schiff Bases. J Inorg Biochem. 2006 Aug;100(8):1368-77
tris(salicylideneamine)  0   *Schiff Bases. Angew Chem Int Ed Engl. 2005 Oct 21;44(41):6689-93
salicylideneaniline  0   *Aniline Compounds *Schiff Bases. Acta Crystallogr C. 2005 May;61(Pt 5):o317-20
bis(salicylidene)diimine  0   *Schiff Bases. Chemistry. 2005 Jun 6;11(12):3698-710
O-(7-amino-4-azaheptyl)oxime of 3-aminopropanal  0   *Schiff Bases. Bioorg Khim. 2005 Mar-Apr;31(2):206-12
salicylideneimine-2-thiophenol  0   *Phenols *Schiff Bases Ligands. Spectrochim Acta A Mol Biomol Spectrosc 2005 Jan 1;61(1-2):157-61
Fe(III)- N ,N'-ethylene-bis (salicylideneiminato)-chloride  0   *Ferric Compounds *Schiff Bases Iron. J Inorg Biochem. 2004 Apr;98(4):589-94
2,5-dihydroxybenzilideneaminoguanidine  0   *Schiff Bases. Gen Physiol Biophys. 2002 Sep;21(3):337-44
cryptand  0   *Ethers, Cyclic *Schiff Bases. Spectrochim Acta A Mol Biomol Spectrosc 2001 Jul;57(8):1611-9
N,N'-bis(salicylidene)-1,6-hexanediamine  0   *Schiff Bases. Spectrochim Acta A Mol Biomol Spectrosc 2001 Jan;57A(1):149-54
7-ethylsalicylidenebenzylamine  0   *Schiff Bases. Spectrochim Acta A Mol Biomol Spectrosc 2000 Dec;56(14):2669-77
2-bromobenzylideneamino-3,3-dimethylguanidine  0   *Guanidines *Schiff Bases Ligands. Neurochem Int 1997 Jan;30(1):95-9
2-chlorobenzylideneamino-3,3-dimethylguanidine  40845-84-9   *Guanidines *Schiff Bases Ligands. Neurochem Int 1997 Jan;30(1):95-9
1-(2-hydroxy-5'-methoxybenzylidene)amino-3-hydroxyguanidine tosylate  158792-20-2   *Guanidines *Schiff Bases. Antiviral Res 1994 Aug;24(4):261-73
LK 11  74143-01-4 4-Morpholinepropanoic acid, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo  *Guanidines *Isoquinolines Schiff Bases. Pharm Res 1993 Apr;10(4):515-20
4-(5-nitrofurfurylideneamino)-3-(furan-2)-5-mercapto-1,2,4-triazole  146173-56-0   *Nitrofurans *Triazoles Schiff Bases. Yao Hsueh Hsueh Pao 1992;27(10):738-42
4-salicylideneamino-3-(furan-2)-5-mercapto-1,2,4-triazole  146173-47-9   *Furans *Triazoles Schiff Bases. Yao Hsueh Hsueh Pao 1992;27(10):738-42
(1,8-di-(2-imidazolyl)-2,7-diazaoctadiene-1,7)-(N,N',N'',N''')-copper(II)  113634-09-6   *Organometallic Compounds *Schiff Bases Copper. Free Radic Res Commun 1990;11(1-3):39
indane-1,3-dione-2-imine-N-acetic acid  130755-94-1   *Schiff Bases. Biol Met 1990;3(1):19
N,N'-bis(2-pyridylmethylene)-1,4-butanediamine (N,N',N'',N''')-Cu(II)diperchlorate  90149-40-9   *Organometallic Compounds *Schiff Bases Copper. Biochem Pharmacol 1990;39(9):1473
1-(5-(carboxyphenylthio)-2-thenylideneamino)hydantoin  126384-99-4   *Benzoates *Hydantoins Schiff Bases. Farmaco 1989;44(12):1217
glucotalooctamine  133397-25-8   *Hexoses *Schiff Bases. Chem Biol Interact 1990;74(1-2):79
1,2,3,4,4a,12a-hexahydro-7,7,10,10-tetramethyl-7H,10H-8,9-dithia-5,12-diazabenzocyclodecene  114646-05-8   *Diazonium Compounds *Schiff Bases. Acta Crystallogr C 1988;44(Pt 4):763
salicylidene-beta-alanine  34295-85-7 beta-Alanine, N-((2-hydroxyphenyl)methylene)  beta-Alanine/*analogs & derivatives Schiff Bases. Biofizika 1980;25(2):199
saddamine  886-08-8   *Schiff Bases. Eur J Drug Metab Pharmacokinet 1979;4(2):117; J Chromatogr 166(2):626;1978; J Pharm Sci 68(3):374;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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