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Selegiline

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Definition: A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.     
Pharmacological Action Antiparkinson Agents; Monoamine Oxidase Inhibitors; Neuroprotective Agents 		Other names Deprenyl; Deprenil; Deprenalin; Selegiline Valeant Brand; Hydrochloride, Selegiline; E 250; Bristol Myers Squibb Brand of Selegiline; Zelapar; Yumex; Valeant Brand of Selegiline; Selegyline; Selegiline, (S)-Isomer; Selegiline, (R,S)-Isomer; Selegiline, (R)-Isomer; Selegiline Hydrochloride, (S)-Isomer; Selegiline Hydrochloride, (R,S)-Isomer; Selegiline Hydrochloride, (R)-Isomer; Selegiline Hydrochloride; L-Deprenyl; JumexDrugs* : EMSAM; ELDEPRYL; SELEGILINE HYDROCHLORIDE; ZELAPAR
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(1-fluoro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine  0   Selegiline/*analogs & derivatives Fluorine Radioisotopes Monoamine Oxidase Inhibitors. J Med Chem. 2011 Oct 27;54(20):7023-9.
N-Methyl,N-propargyphenylethylamine  0   Selegiline/*analogs & derivatives. J Pharmacol Toxicol Methods. 2005 Nov-Dec;52(3):373-8
p-fluoro-L-deprenyl  0   Selegiline/*analogs & derivatives. Psychopharmacology (Berl). 2005 Oct;182(1):95-103
deprenyl-N-oxide  0   Selegiline/*analogs & derivatives. J Chromatogr Sci. 2004 Jan;42(1):21-6
selegiline-N-oxide  0   Selegiline/*analogs & derivatives. J Chromatogr B Biomed Sci Appl 2001 Aug 5;759(1):125-33
4-fluorodeprenyl  103596-43-6   Selegiline/*analogs & derivatives. J Med Chem 1990;33(7):2015

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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