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Serine Endopeptidases

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Definition: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.  do not confuse with SERINE PROTEASES   
Examples Acrosin; Cathepsin G; Chymases; Chymotrypsin; Complement Factor B; Complement Factor D; Complement Factor I; Endopeptidase K; Enteropeptidase; Factor VIIa; Factor IXa; Factor Xa; Factor XIa; Factor XIIa; Fibrinolysin; Furin; Granzymes; Kallikreins; Lactoferrin; Mannose-Binding Protein-Associated Serine Proteases; Myeloblastin; Pancreatic Elastase; Plasminogen Activators; Pronase; Proprotein Convertase 1; Proprotein Convertase 2; Proprotein Convertase 5; Subtilisins; Thrombin; Tissue Plasminogen Activator; Trypsin; Tryptases; Urokinase-Type Plasminogen Activator; Venombin A 		Other names Endopeptidases, Serine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TMPRSS4 protein, zebrafish  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases *Zebrafish Proteins. Biol Chem. 2011 Jun;392(7):653-64
htrA protein, Bacillus anthracis  EC 3.4.21.-   *Bacterial Proteins *Serine Endopeptidases. Appl Environ Microbiol. 2009 Oct;75(19):6157-67
Q8009 protease, Pseudonaja textilis  EC 3.4.21.-   *Serine Endopeptidases *Reptilian Proteins Elapid Venoms. Exp Mol Pathol 2009 Dec;87(3):204-11
ModSP protein, Drosophila  EC 3.4.21.-   *Serine Endopeptidases *Drosophila Proteins. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12442-7
Cur I 1 allergen, Curvularia lunata  EC 3.4.21.-   *Allergens *Serine Endopeptidases Fungal Proteins. J Clin Immunol 2009 May;29(3):292-302
SEVA TB ES-31 antigen, Mycobacterium tuberculosis  EC 3.4.21.-   *Antigens, Bacterial *Serine Endopeptidases Bacterial Proteins Glycoproteins Metalloproteases. Int J Tuberc Lung Dis 2005 Aug;9(8):915-9
Pic protein, E coli  EC 3.4.21.-   *Serine Endopeptidases *Escherichia coli Proteins Hemagglutinins. Infect Immun 2009 Jun;77(6):2465-73
T-SP1 protein, human  EC 3.4.21.-   *Serine Endopeptidases. Biol Chem 2008 Dec;389(12):1495-504
RHBDD1 protein, human  EC 3.4.21.-   *Serine Endopeptidases. Cell Mol Life Sci 2008 Nov;65(23):3822-9
RBL12 protein, Arabidopsis  EC 3.4.21.-   *Serine Endopeptidases *Mitochondrial Proteins *Arabidopsis Proteins Membrane Proteins. Plant Mol Biol 2008 Sep;68(1-2):159-71
Pet protein, E coli  EC 3.4.21.-   *Bacterial Toxins *Enterotoxins *Serine Endopeptidases *Escherichia coli Proteins.
Omi protein, Drosophila  EC 3.4.21.-   *Serine Endopeptidases *Drosophila Proteins. Cell Death Differ 2008 Jun;15(6):1073-83
neurobin protein, mouse  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. Biochem J 2008 May 15;412(1):81-91
TMPRSS4 protein, human  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. Oncogene. 2008 Apr 17;27(18):2635-47
nucleosome releasing factor, human  EC 3.4.21.-   *Serine Endopeptidases. FEBS Lett 2007 Nov 27;581(28):5382-8
cadeprin  EC 3.4.21.-   *Serine Endopeptidases. Eur J Neurosci 2007 Oct;26(7):1870-80
DESC1 protein, human  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. Br J Cancer 2007 Jul 16;97(2):201-9
Lon4 protein, Arabidopsis  EC 3.4.21.53   *Serine Endopeptidases *Arabidopsis Proteins. Plant Cell Physiol 2007 Jun;48(6):881-5
Deg15 protein, Arabidopsis  EC 3.4.21.-   *Serine Endopeptidases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2007 Jul 3;104(27):11501-6
high-temperature requirement factor A1, Xenopus  EC 3.4.21.-   *Serine Endopeptidases *Xenopus Proteins. Dev Cell 2007 Aug;13(2):226-41
Deg1 protein, Arabidopsis  EC 3.4.21.-   *Serine Endopeptidases *Arabidopsis Proteins. Plant Cell 2007 Mar;19(3):1039-47
FSAP protein, mouse  EC 3.4.21.-   *Serine Endopeptidases. Biochem J 2007 Jun 1;404(2):191-6
LISPDE protein, human  EC 3.4.21.-   *Serine Endopeptidases. Biochim Biophys Acta 2007 Feb;1773(2):243-53
PRSS23 protein, mouse  EC 3.4.21.-   *Serine Endopeptidases. Biol Reprod 2006 Dec;75(6):823-35
PRSS35 protein, mouse  EC 3.4.21.-   *Serine Endopeptidases. Biol Reprod 2006 Dec;75(6):823-35
Deg2 protein, Arabidopsis  EC 3.4.21.-   *Serine Endopeptidases *Arabidopsis Proteins. FEBS Lett 2006 Dec 22;580(30):6929-32
polyserase-1, rat  EC 3.4.21.-   *Serine Endopeptidases. Biochem J 2006 Dec 15;400(3):551-61
polyserase-1, mouse  EC 3.4.21.-   *Serine Endopeptidases. Biochem J 2006 Dec 15;400(3):551-61
PREP protein, human  EC 2.4.21.25   *Serine Endopeptidases *Mitochondrial Proteins. J Biol Chem 2006 Sep 29;281(39):29096-104
erythroelastase-IX, human  EC 3.4.21.-   *Serine Endopeptidases. Blood Coagul Fibrinolysis 2005 Jul;16(5):355-63
spc4 protein, Xenopus  EC 3.4.21.-   *Serine Endopeptidases *Xenopus Proteins.
Tequila protein, Drosophila  EC 3.4.21.-   *Serine Endopeptidases *Drosophila Proteins. Science 2006 Aug 11;313(5788):851-3
Ynm3 protein, S cerevisiae  EC 3.4.21.-   *Serine Endopeptidases *Saccharomyces cerevisiae Proteins. Yeast 2000 Sep 15;16(12):1089-97
polyserase-3, human  EC 3.4.21.-   *Serine Endopeptidases. BMC Biochem 2006;7(dup#5):9
PCSK9 protein, rat  EC 3.4.21.-   *Serine Endopeptidases. Biochem Cell Biol 2006 Feb;84(1):80-92
RBL2 protein, Arabidopsis  EC 3.4.21.-   *Serine Endopeptidases *Arabidopsis Proteins Membrane Proteins. FEBS Lett 2005 Oct 24;579(25):5723-8
prothrombin activator protease, Pseudonaja textilis  EC 3.4.21.-   *Elapid Venoms *Serine Endopeptidases. Br J Haematol 2005 Oct;131(2):237-46
prosemin protein, human  EC 3.4.21.-   *Serine Endopeptidases Neoplasm Proteins Nerve Tissue Proteins. FEBS J 2005 Oct;272(19):4911-23
NS3 protease, dengue virus  EC 3.4.21.-   *Serine Endopeptidases. J Biol Chem 2005 Aug 5;280(31):28766-74
TMPRSS6 protein, human  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. Mol Cells 2005 Apr 30;19(2):223-7
insulin-like growth factor binding proteinase, human  EC 3.4.21.-   *Serine Endopeptidases. J Cell Biochem 2005 Feb 15;94(3):470-84
jararassin-I, Bothops jararaca  EC 3.4.21.-   *Serine Endopeptidases *Viper Venoms. Acta Biochim Biophys Sin (Shanghai) 2004 Dec;36(12):798-802
C1RL protein, human  Ec 3.4.21.-   *Serine Endopeptidases. Biochem J 2005 Apr 1;387(Pt 1):165-73
Vpr protein, Bacillus subtilis  EC 3.4.21.-   *Bacterial Proteins *Serine Endopeptidases. Protein Expr Purif 2005 Jan;39(1):1-7
ClpP protein, Streptococcus pneumoniae  EC 3.4.21.-   *Bacterial Proteins *Serine Endopeptidases. J Biol Chem 2005 Apr 22;280(16):16185-96
PRSS22 protein, human  EC 3.4.21.59   *Serine Endopeptidases. J Biol Chem 2001 Dec 28;276(52):49169-82
TESSP-1 protein, mouse  EC 3.4.21.-   *Serine Endopeptidases. Mol Reprod Dev. 2005 Jan;70(1):1-10
KN-BJ2 protein, Bothrops jararaca  EC 3.4.21.-   *Crotalid Venoms *Serine Endopeptidases. Protein Sci 2004 Sep;13(9):2355-69
polyserase-2, human  EC 3.4.21.-   *Serine Endopeptidases. J Biol Chem. 2005 Jan 21;280(3):1953-61
Habp2 protein, mouse  EC 3.4.21.-   *Serine Endopeptidases.
DESC4 protein, rat  EC 3.4.21.-   *Serine Endopeptidases. Cell Mol Life Sci. 2004 Nov;61(22):2866-77
Desc1 protein, mouse  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. J Biol Chem 2004 Nov 5;279(45):46981-94
spinesin protein, mouse  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. Biochem Biophys Res Commun 2004 Nov 5;324(1):333-40
Epi p 1 allergen, Epicoccum purpurascens  EC 3.4.21.-   *Serine Endopeptidases *Antigens, Plant. FEMS Immunol Med Microbiol 2004 Oct 1;42(2):205-11
alkaline serine protease I, Streptomyces  EC 3.4.21.-   *Bacterial Proteins *Serine Endopeptidases. Biochem Biophys Res Commun 2004 Aug 13;321(1);45-50
corin protein, rat  EC 3.4.21.-   *Serine Endopeptidases. Am J Physiol Heart Circ Physiol 2004 Oct;287(4):H1516-21
hyaluronan-binding protease, human  EC 3.4.21.-   *Serine Endopeptidases. Eur J Cell Biol 2004 Jan;82(12);597-604
transmembrane serine protease-1, rat  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases. Biol Chem. 2003 Oct-Nov;384(10-11):1483-95
Prss11 protein, mouse  EC 3.4.21.-   *Serine Endopeptidases. Dev Growth Differ 2004 Jun;46(3):257-74
roughoid protein, Drosophila  EC 3.4.21.-   *Membrane Proteins *Serine Endopeptidases *Drosophila Proteins. Genes Dev 2000 Jul 1;14(13):1651-63
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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