encyclopedia of medical concepts
ψ 
ψ 
ψ 

Serotonin

More information in Books or onNLM PubMed
Definition: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.  /antag   
Pharmacological Action Serotonin Receptor Agonists
See Also Receptors, Serotonin; Serotonin Agents; Serotonin Syndrome
Examples 5-Methoxytryptamine 		Other names 5-Hydroxytryptamine; 5-HT; 5 Hydroxytryptamine; Hydroxytryptamine; Hippophaine; Enteramine; 3-(2-Aminoethyl)-1H-indol-5-ol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-hydroxy-N,N-diisopropyltryptamine  0   Serotonin/*analogs & derivatives. J Forensic Sci. 2011 Jul;56(4):1044-8.
arachidonyl serotonin  0   *Arachidonic Acids Serotonin/*analogs & derivatives. Biopolymers. 2011 Dec;95(12):871-80
Nb-(alpha-hydroxynaphthoyl)serotonin  0   *Naphthols Serotonin/*analogs & derivatives Janus Kinase 3/antagonists & inhibitors. Br J Haematol 2010 Jan;148(1):132-43
N-caffeoylserotonin  0   *Caffeic Acids Serotonin/*analogs & derivatives. Phytomedicine 2008 Dec;15(12):1093-8
7-azaserotonin  0   Serotonin/*analogs & derivatives. J Am Chem Soc 2006 Nov 15;128(45):14426-7
1-oxo-5-hydroxytryptamine  0   *Benzofurans Serotonin/*analogs & derivatives Receptors, Serotonin, 5-HT3/agonists. Org Lett 2007 Aug 16;9(17):3205-7
N-feruloylserotonin  0   Serotonin/*analogs & derivatives. J Agric Food Chem. 2006 Jul 12;54(14):4970-6
serotonin-rat serum albumin conjugate  0   *Serum Albumin Serotonin/*analogs & derivatives. Bull Exp Biol Med 2005 Jan;139(1):73-4
5-sulfatoxy-N-acetylserotonin  0   Serotonin/*analogs & derivatives Melatonin. J Pineal Res 1999 May;6(4):221-6
(4-serotonyl)-4-serotonin  0   *Serotonin. Nitric Oxide 1997;1(6):442-52
4-nitroso-5-HT  0   *Nitroso Compounds *Serotonin. Nitric Oxide 1997;1(6):442-52
4-nitro-5-HT  0   *Nitro Compounds *Serotonin. Nitric Oxide 1997;1(6):442-52
N-(p-coumaroyl)serotonin  0   *Serotonin. J Interferon Cytokine Res 1998 Jun;18(6):423-8
arachidonoylserotonin  0   *Arachidonic Acids Serotonin/*analogs & derivatives. Biochem Biophys Res Commun 1998 Jul 30;248(3):515-22
serotonin-BSA conjugate  0   *Serotonin *Serum Albumin, Bovine. Biull Eksp Biol Med 1996 Apr;121(4):392-5
gamma-glutamyl-5-hydroxytryptamine  61059-62-9   Serotonin/*analogs & derivatives. Neurochem Res 1994 Feb;19(2):217-22
serotonin-O-carboxymethyl-Gly-Tyr  133790-08-6   *Dipeptides Serotonin/*analogs & derivatives Iodine Radioisotopes. J Pharmacol Exp Ther 1991;259(3):1360
5-benzyloxytryptamine  20776-45-8   Serotonin/*analogs & derivatives. Life Sci 1991;49(6):409
N-(4-azido-2-nitrophenyl)-5-hydroxytryptamine  94452-30-9   *Azides Serotonin/*analogs & derivatives. J Neurochem 1990;54(3):963
serotonin adipinate  16031-83-7   *Adipic Acids Serotonin/*analogs & derivatives. Khirurgiia (Mosk) 1989(3):113
4-(7'-(tryptamine-4,5-dione))-2,4''-bis-5-hydroxytryptamine  118230-91-4   *Indolequinones Serotonin/*analogs & derivatives. J Pharm Sci 1988;77(11):911
7,7'-bis-(5-hydroxytryptamine-4-one)  118230-89-0   Serotonin/*analogs & derivatives. J Pharm Sci 1988;77(11):911
N,N-di-n-propylserotonin  36288-75-2   Serotonin/*analogs & derivatives. J Med Chem 1988;31(4):867
5-carboxamidotryptamine  74885-09-9   Serotonin/*analogs & derivatives.
Pharma Action Serotonin Receptor Agonists 		Br J Pharmacol 1985;84(2):533
3-(2-(4-azidobenzamidino)ethyl)-5-hydroxyindole  98409-42-8   *Azides Serotonin/*analogs & derivatives. Mol Pharmacol 1985;28(2):185
2-methyl-5-HT  78263-90-8   Serotonin/*analogs & derivatives. Nature 1985;316(6024):126
N-(2-nitro-4-azidophenyl)serotonin  0   *Azides Serotonin/*analogs & derivatives. J Neurochem 1984;43(6):1680
alpha-methylserotonin  22965-81-7   Serotonin/*analogs & derivatives.
Pharma Action Serotonin Receptor Agonists 		Life Sci 1984;35(5):477
4-azido-3-nitrophenyl-azo-(5-hydroxytryptamine)  83919-48-6 1H-Indol-5-ol, 3-(2-aminoethyl)-6-((4-azido-3-nitrophenyl)azo)  Serotonin/*analogs & derivatives. J Biol Chem 1982;257(24):15145
beta-hydroxyserotonin  40979-78-0 1H-Indole-3-methanol, alpha-(aminomethyl)-5-hydroxy  Serotonin/*analogs & derivatives. Strahlentherapie 1982;158(6):375
5-hydroxytryptamine O-sulfate  16310-20-6   Serotonin/*analogs & derivatives. J Neurochem 1981;37(4):1068
6-fluoroserotonin  62105-96-8 1H-Indol-5-ol, 3-(2-aminoethyl)-6-fluoro  Serotonin/*analogs & derivatives. FEBS Lett 1981;136(2):325
6-hydroxytryptamine  443-31-2   Serotonin/*analogs & derivatives. Adv Biochem Psychopharmacol 1980;25:367
5-methoxy-alpha-methyltryptamine  1137-04-8   Serotonin/*analogs & derivatives. Biol Psychiatry 1980;15(2):349
serotonin-binding protein  0   *Carrier Proteins Serotonin. J Neurochem 1980;34(6):1719
desoxyribulo-serotonin  70166-82-4 D-Psicose, 1-deoxy-1-((2-(5-hydroxy-1H-indol-3-yl)ethyl)amino)-, ethanedioate (salt)  Serotonin/*analogs & derivatives. Thromb Res 14(1):199;1979
desoxyfructo-serotonin  57003-86-8 D-Fructose, 1-deoxy-1-((2-(5-hydroxy-1H-indol-3-yl)ethyl)amino)  Serotonin/*analogs & derivatives.
Pharma Action Leprostatic Agents 		Thromb Res 14(1):199;1979
4,6-difluoroserotonin  62105-98-0 1H-Indol-5-ol, 3-(2-aminoethyl)-4,6-difluoro  Serotonin/*analogs & derivatives Fluorine. Science 200(4341):537;1978
creatinine sulfate, serotonin drug combination  0 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one cpd with 3-(2-aminoethyl)-1H-indol-5-ol sulfate  *Creatinine *Serotonin Drug Combinations.
Pharma Action Radiation-Protective Agents 		Comp Biochem Physiol 56(1):41;1976
N-methylserotonin  1134-01-6   Serotonin/*analogs & derivatives. Biochem Biophys Res Commun 54(2):751;1973
N-acetylserotonin  1210-83-9   Serotonin/*analogs & derivatives. Experientia 34(11):1434;1978; Hormone Res 8:84;1977; Mol Pharm 9(5):605;1973

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy