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Silymarin

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Definition: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.     
Pharmacological Action Antioxidants; Protective Agents
See Also Milk Thistle 		Other names Silimarin; Legalon; Karsil; Carsil
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
EH-1501  0   *Plant Extracts Silymarin. Acta Biomed. 2011 Apr;82(1):82-9
7-O-galloylsilybin  0   Silymarin/*analogs & derivatives. J Med Chem. 2011 Oct 27;54(20):7397-407.
dehydrosilymarin  0   Silymarin/*analogs & derivatives. Acta Pharmacol Sin. 2011 Jul;32(7):973-80
isosilybin A  0   Silymarin/*analogs & derivatives Stereoisomerism. Carcinogenesis 2007 Jul;28(7):1533-42
silybin-phytosome  0   Silymarin/*analogs & derivatives. Invest New Drugs 2007 Apr;25(2):139-46
dehydrosilybin  0   *Silymarin. Cell Biol Toxicol 2006 Mar;22(2):81-90
silybin-beta-cyclodextrin  0   *Silymarin *beta-Cyclodextrins. Diabetes Nutr Metab. 2002 Aug;15(4):221-31
silybin  22888-70-6   *Silymarin Milk Thistle.
Pharma Action Antioxidants
silybin 11-O-phosphate  0   *Phosphoric Acid Esters Silymarin/*analogs & derivatives. Farmaco 1994 Jan;49(1):75-6
isosilybin  72581-71-6   Silymarin/*analogs & derivatives. Pharmacol Res 1992 Feb-Mar;25(2):147-54
IdB 1016  134499-06-2   *Phosphatidylcholines *Silymarin. Free Radic Res Commun 1990;11(1-3):109
silybin dihemisuccinate  34482-56-9   Silymarin/*analogs & derivatives. Arch Pharm (Weinheim) 1983;316(5):426
silydianin  29782-68-1   *Silymarin Isomerism. Experientia 33(11):1417;1977; Experientia 33(12):1568;1977; Planta Med 32(4):331;1977
silychristin  33889-69-9   *Silymarin Isomerism. Experientia 33(11):1417;1977; Experientia 33(12):1568;1977; Planta Med 32(4):331;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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