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Growth Hormone-Releasing Hormone

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Definition: A peptide of 44 amino acids in most species that stimulates the release and synthesis of GROWTH HORMONE. GHRF (or GRF) is synthesized by neurons in the ARCUATE NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, GHRF stimulates GH release by the SOMATOTROPHS in the PITUITARY GLAND.  DF: SRH   
Pharmacological Action Hormones
Examples Sermorelin 		Other names Somatotropin-Releasing Hormone; Somatotropin-Releasing Factor 44; Somatocrinin; Growth Hormone-Releasing Factor; Somatotropin Releasing Hormone; Somatotropin Releasing Factor 44; Growth Hormone Releasing Hormone; Growth Hormone Releasing Factor 44; Growth Hormone Releasing Factor; hpGRF 44; Somatoliberin; Human Pancreatic Growth Hormone-Releasing Factor; Growth Hormone-Releasing Factor 44; GRF 1-44; GHRH 1-44
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)  0   Sermorelin/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors. Cancer Lett 2010 Jul 1;293(1):31-40
AKL-0707  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/agonists. Kidney Int. 2010 Mar;77(5):450-8
GHRP-6, Lys(3)  0   *Oligopeptides Growth Hormone-Releasing Hormone. Am J Physiol Gastrointest Liver Physiol 2007 May;292(5):G1376-84
Pro-GHRH(2-44) peptide, human  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Regul Pept. 2006 Jan 15;133(1-3):20-6
Pro-Pro-hGHRH(1-44) peptide, human  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Regul Pept. 2006 Jan 15;133(1-3):20-6
CJC 1295  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Endocrinology 2005 Jul;146(7):3052-8
Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Acta Pharmacol Sin. 2004 Nov;25(11):1464-70
tesamorelin  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Lipodystrophy. AIDS Patient Care STDS. 2003 Sep;17(9):489EGRIFTA
JV 1-53  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors Vasoactive Intestinal Peptide/antagonists & inhibitors. Int J Cancer 2002 Apr 1;98(4):624-9
JV 1-52  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors Vasoactive Intestinal Peptide/antagonists & inhibitors. Int J Cancer 2002 Apr 1;98(4):624-9
vasoactive intestinal peptide (1-7)-growth hormone-releasing factor (8-27), lysyl(15)-arginyl(16)-leucyl(27)  0   Growth Hormone-Releasing Hormone Vasoactive Intestinal Peptide Receptors, Vasoactive Intestinal Peptide/agonists. Eur J Neurosci 2001 Feb;13(4):839-43
JI-38  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. Regul Pept 2001 Jan 12;96(3):119-24
JV 1-38  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors. Prostate 2000 Jul 1;44(2):172-80
JV 1-36  0   Growth Hormone-Releasing Hormone/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors. Proc Natl Acad Sci U S A 1999 Dec 21;96(26):14894-8
G 7039  0   *Oligopeptides Growth Hormone-Releasing Hormone. Endocrinology 1997 Oct;138(10):4316-23
MZ 5-156  0   Sermorelin/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors. Peptides 1997;18(3):431-8
somatotropin-releasing hormone-(1-30)-amide, Ala(2)-Nle(27)-GABA(30)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. Biomed Chromatogr 1996 Mar-Apr;10(2):89-91
growth hormone releasing hormone-related peptide  0   *Growth Hormone-Releasing Hormone. Endocrinology 1996 May;137(5):2159-62
U 90349E  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. J Dairy Sci 1995 Jul;78(7):1489-97
MZ 4-243  0   Sermorelin/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors. Endocrinology 1995 Sep;136(9):3849-55
MZ 4-71  0   Sermorelin/*analogs & derivatives Growth Hormone-Releasing Hormone/antagonists & inhibitors. Endocrinology 1995 Sep;136(9):3849-55
somatotropin-releasing hormone (1-23), 3'-5'  0   *Growth Hormone-Releasing Hormone. Immunomethods 1994 Oct;5(2):91-7
growth hormone-releasing peptide-2  0   *Oligopeptides Growth Hormone-Releasing Hormone. Regul Pept 1994 Oct 21;53(3):195-201
somatotropin-releasing hormone (1-30)amide, Ile(2)-Ser(8)-Ala(15)-Leu(27)-Ser(28)-Hse(30)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Dairy Sci 1994 Sep;77(9):2518-25
somatotropin-releasing hormone (4-29)-OH, Ala(15,29)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. Int J Pept Protein Res 1994 Aug;44(2):123-9
somatotropin-releasing hormone (1-30)-amide, Ala(2)-Leu(15)-Nle(27)-GABA(30)  134101-56-7   Growth Hormone-Releasing Hormone/*analogs & derivatives. Neuroendocrinology 1994 Apr;59(4):371-9
somatotropin-releasing hormone (1-30) amide  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Endocrinol Invest 1993 Nov;16(10):793-8
growth hormone-releasing factor (1-32)amide, Ala(15)-Leu(27)  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Int J Pept Protein Res 1993 Dec;42(6):497-503
somatotropin releasing hormone (1-32)NH2, Pro(15)-Leu(27)  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Int J Pept Protein Res 1993 Dec;42(6):497-503
somatotropin-releasing hormone (1-32)-amide, isoAsp(8)-Leu(27)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Pharm Biomed Anal 1993 Apr-May;11(4-5):367-73
somatotropin-releasing hormone-(1-32)amide, Asp(8)-Leu(27)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Pharm Biomed Anal 1993 Apr-May;11(4-5):367-73
somatotropin-releasing hormone(1-32) amide, Leu(27)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Pharm Biomed Anal 1993 Apr-May;11(4-5):367-73
alanyl-histidyl-(2-naphthyl)alanyl-tryptophyl-phenylalanyl-lysinamide  141925-59-9   *Oligopeptides Growth Hormone-Releasing Hormone. Endocrinology 1993 Mar;132(3):1286-91
Ro 23-7861  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Pharm Sci 1992 Jul;81(7):635-9
somatotropin releasing hormone (3-29)NH2, Leu(27)  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Pept Res 1991 Mar-Apr;4(2):72-8
somatotropin-releasing hormone (1-29)-Gly-Gly-Gly-Gly-Cys-NH2  0   *Peptide Fragments *Growth Hormone-Releasing Hormone. Clin Chim Acta 1991 Oct 31;202(3):243-54
somatotropin releasing factor 40, Leu(27)  107761-41-1   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Int J Pept Protein Res 1991 Nov;38(5):401-8
somatotropin releasing hormone (1-44)-OH, Leu(27)  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. Arch Biochem Biophys 1991;286(2):638
somatotropin-releasing hormone (1-32)amide, His(1),Nle(27)  94034-78-3   Growth Hormone-Releasing Hormone/*analogs & derivatives. Endocrinology 1990;127(5):2117
somatotropin releasing hormone (1-45)  112602-83-2   Growth Hormone-Releasing Hormone/*analogs & derivatives. Horm Metab Res 1989;21(12):690
pro-growth hormone releasing hormone, mouse  125200-87-5   *Protein Precursors *Growth Hormone-Releasing Hormone. Mol Endocrinol 1989;3(11):1693
somatotropin releasing hormone (1-29)  90830-28-7   *Peptide Fragments *Growth Hormone-Releasing Hormone. Biopolymers 1988;27(12):1897
somatotropin releasing hormone-(1-29)NHEt, 1-N-MeTyr-27-Nle-28-Asn  118202-57-6   Growth Hormone-Releasing Hormone/*analogs & derivatives. Ann N Y Acad Sci 1988;527:44
growth hormone releasing hexapeptide, Lys(6), thionated  0   *Oligopeptides Growth Hormone-Releasing Hormone. Biochem Biophys Res Commun 1988;150(3):1017
somatotropin releasing hormone (1-26)amide  91921-54-9   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Endocrinol Jpn 1986;33(4):519
somatotropin releasing hormone (1-45), 27-Leu-45-Gly  105953-59-1   Growth Hormone-Releasing Hormone/*analogs & derivatives. J Mol Biol 1986;191(3):553
somatotropin releasing hormone-(1-29), 1-His-2-Ala-27-Nle  112372-78-8   Growth Hormone-Releasing Hormone/*analogs & derivatives Iodine Radioisotopes. Neuroendocrinology 1986;44(1):108
pre-pro-growth hormone releasing factor  0   *Protein Precursors *Growth Hormone-Releasing Hormone. Endocrinology 1986;118(1):156
somatotropin releasing hormone (1-40-OH), Ac-Tyr(1)  91728-73-3   Growth Hormone-Releasing Hormone/*analogs & derivatives. Mol Pharmacol 1986;29(1):23
somatotropin releasing hormone (1-32)amide, His(1)-I-Tyr(10)-Nle(27)  97741-14-5   Growth Hormone-Releasing Hormone/*analogs & derivatives. Endocrinology 1985;117(1):424
somatotropin releasing hormone (1-43)  86472-71-1   *Peptide Fragments *Growth Hormone-Releasing Hormone. Proc Natl Acad Sci USA 1985;82(9):2970
somatotropin releasing hormone (1-24)amide  95415-63-7   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. J Dairy Sci 1984;67(12):2881
somatotropin releasing-hormone (1-29), 2-Ala  0   Growth Hormone-Releasing Hormone/*analogs & derivatives. Biochem Biophys Res Commun 1984;124(1):217
somatotropin releasing hormone (1-37)amide  90599-36-3 Somatoliberin, 37-L-alpha-glutamine-38-de-L-arginine-39-deglycine-40-de-L-alanine-41-de-L-arginine-42-de-L-alanine-43-de-L-arginine-44-de-L-leucinamide-, (S-(R*,R*))  *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1984;32(3):1200
somatotropin releasing hormone, N(alpha) biotinyl(1-44)amide  92170-23-5 Somatoliberin, N-(5-(hexahydro-2-oxo-1H-thieno(3,4-d)imidazol-4-yl)-1-oxopentyl)-, (3aS-(3aalpha,4beta,6aalpha))  *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives. Chem Pharm Bull (Tokyo) 1984;32(3):1200
GRF-PHI heptacosapeptide amide  90967-78-5 L-Isoleucinamide, L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-lerythro  *Peptides Gastrointestinal Hormones Growth Hormone-Releasing Hormone. Chem Pharm Bull (Tokyo) 1984;32(2):739
growth hormone releasing hexapeptide  87616-84-0 L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl  *Oligopeptides Growth Hormone-Releasing Hormone Stereoisomerism. Endocrinology 1984;114(5):1537
somatotropin releasing hormone (1-37)  0   *Peptide Fragments *Growth Hormone-Releasing Hormone Pancreatic Hormones. Gann 1983;74(6):814
somatotropin releasing hormone (1-44)amide  0   *Peptide Fragments Growth Hormone-Releasing Hormone/*analogs & derivatives Pancreatic Hormones. Gann 1983;74(6):814
somatocrinin receptor  0   *Receptors, Neuropeptide *Receptors, Pituitary Hormone-Regulating Hormone Growth Hormone-Releasing Hormone. Proc Natl Acad Sci USA 1983;80(21):6538
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