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Sparsomycin

More information in Books or onNLM PubMed
Definition: An antitumor antibiotic produced by Streptomyces sparsogenes. It inhibits protein synthesis in 70S and 80S ribosomal systems.  an antineoplastic antibiotic   
Pharmacological Action Antibiotics, Antineoplastic; Protein Synthesis Inhibitors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ethyldeshydroxysparsomycin  119410-38-7   Sparsomycin/*analogs & derivatives. Anticancer Res 1992 Jan-Feb;12(1):167-70
phenol-alanine sparsomycin  132337-89-4   Sparsomycin/*analogs & derivatives. Antimicrob Agents Chemother 1991;35(1):10
n-pentylsparsomycin  114991-34-3   Sparsomycin/*analogs & derivatives. Invest New Drugs 1990;8(1):25
MDL 20828  98930-79-1 2-Propenamide, N-(2-hydroxy-1-(((4-hydroxyphenyl)sulfinyl)methyl)ethyl)-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)  Sparsomycin/*analogs & derivatives Peptide Chain Elongation, Translational Peptidyl Transferases/antagonists & inhibitors. Biochem Biophys Res Commun 1990;166(2):673
deshydroxysparsomycin  113597-70-9   Sparsomycin/*analogs & derivatives. Anticancer Res 1988;8(6):1381
octylsparsomycin  88001-59-6   Sparsomycin/*analogs & derivatives. J Med Chem 1984;27(3):301
MDL 19152  61786-72-9   Sparsomycin/*analogs & derivatives. Biochem Biophys Res Commun 1983;114(1):1

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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